(25 nodes) Translesion synthesis by POLK network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpa2	Replication protein A2. (278 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSPFOP00000003063	REV3 like, DNA directed polymerase zeta catalytic subunit. (2861 aa)
	LOC103132215	Ubiquitin-like domain-containing protein. (331 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	LOC103142380	RPA_C domain-containing protein. (255 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	LOC103152057	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	LOC103147141	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	rpa3	Replication protein A3. (122 aa)
	rfc1	Replication factor C subunit 1. (1166 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (310 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (591 aa)
	LOC103141722	ATPase family AAA domain containing 5a. (1812 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ENSPFOP00000014359	Methionine sulfoxide reductase B1b. (471 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	ENSPFOP00000015873	REV1 DNA directed polymerase. (746 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	LOC103133711	KxDL motif containing 1. (185 aa)
	ENSPFOP00000018137	Polymerase (DNA directed) kappa. (592 aa)
	ubb	Ubiquitin B. (259 aa)
	ENSPFOP00000026331	Uncharacterized protein. (197 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPFOP00000003063	ENSPFOP00000014359	ENSPFOP00000003063	ENSPFOP00000014359	REV3 like, DNA directed polymerase zeta catalytic subunit.	Methionine sulfoxide reductase B1b.	0.798
ENSPFOP00000003063	ENSPFOP00000015873	ENSPFOP00000003063	ENSPFOP00000015873	REV3 like, DNA directed polymerase zeta catalytic subunit.	REV1 DNA directed polymerase.	0.997
ENSPFOP00000003063	ENSPFOP00000018137	ENSPFOP00000003063	ENSPFOP00000018137	REV3 like, DNA directed polymerase zeta catalytic subunit.	Polymerase (DNA directed) kappa.	0.950
ENSPFOP00000003063	ENSPFOP00000026331	ENSPFOP00000003063	ENSPFOP00000026331	REV3 like, DNA directed polymerase zeta catalytic subunit.	Uncharacterized protein.	0.802
ENSPFOP00000003063	LOC103141722	ENSPFOP00000003063	ENSPFOP00000013103	REV3 like, DNA directed polymerase zeta catalytic subunit.	ATPase family AAA domain containing 5a.	0.802
ENSPFOP00000003063	LOC103142380	ENSPFOP00000003063	ENSPFOP00000004994	REV3 like, DNA directed polymerase zeta catalytic subunit.	RPA_C domain-containing protein.	0.763
ENSPFOP00000003063	RPA1	ENSPFOP00000003063	ENSPFOP00000012296	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.798
ENSPFOP00000003063	pcna	ENSPFOP00000003063	ENSPFOP00000010825	REV3 like, DNA directed polymerase zeta catalytic subunit.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.993
ENSPFOP00000003063	rfc1	ENSPFOP00000003063	ENSPFOP00000010530	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C subunit 1.	0.899
ENSPFOP00000003063	rfc2	ENSPFOP00000003063	ENSPFOP00000006102	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C (activator 1) 2.	0.934
ENSPFOP00000003063	rfc3	ENSPFOP00000003063	ENSPFOP00000014376	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C (activator 1) 3.	0.934
ENSPFOP00000003063	rfc4	ENSPFOP00000003063	ENSPFOP00000005779	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C (activator 1) 4.	0.934
ENSPFOP00000003063	rfc5	ENSPFOP00000003063	ENSPFOP00000014946	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C (activator 1) 5.	0.934
ENSPFOP00000003063	rpa1	ENSPFOP00000003063	ENSPFOP00000004158	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.798
ENSPFOP00000003063	rpa2	ENSPFOP00000003063	ENSPFOP00000014233	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A2.	0.763
ENSPFOP00000003063	rpa3	ENSPFOP00000003063	ENSPFOP00000008786	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication protein A3.	0.771
ENSPFOP00000003063	uba52	ENSPFOP00000003063	ENSPFOP00000001094	REV3 like, DNA directed polymerase zeta catalytic subunit.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.680
ENSPFOP00000014359	ENSPFOP00000003063	ENSPFOP00000014359	ENSPFOP00000003063	Methionine sulfoxide reductase B1b.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.798
ENSPFOP00000014359	ENSPFOP00000015873	ENSPFOP00000014359	ENSPFOP00000015873	Methionine sulfoxide reductase B1b.	REV1 DNA directed polymerase.	0.669
ENSPFOP00000014359	ENSPFOP00000018137	ENSPFOP00000014359	ENSPFOP00000018137	Methionine sulfoxide reductase B1b.	Polymerase (DNA directed) kappa.	0.686