60 items (Poecilia formosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103133374-2	Histone H4. (103 aa)
	ENSPFOP00000029491	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
	ENSPFOP00000028950	Reverse transcriptase domain-containing protein. (609 aa)
	ENSPFOP00000028055	Reverse transcriptase domain-containing protein. (432 aa)
	LOC103130469-2	Histone H2B 1/2-like. (124 aa)
	ENSPFOP00000025830	Uncharacterized protein. (2090 aa)
	ENSPFOP00000023229	Uncharacterized protein. (235 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4119 aa)
	ENSPFOP00000021397	Reverse transcriptase domain-containing protein. (784 aa)
	LOC103133374-5	Histone H4. (103 aa)
	LOC103154042-3	Histone H2B 1/2-like. (124 aa)
	LOC103154042-2	Histone H2B 1/2-like. (124 aa)
	LOC103133374-4	Histone H4. (103 aa)
	LOC103144613-3	Histone H2B 1/2. (124 aa)
	LOC103144613-2	Histone H2B 1/2. (124 aa)
	ENSPFOP00000020401	Histone H2B; Belongs to the histone H2B family. (124 aa)
	LOC103153205	Histone H2B; Belongs to the histone H2B family. (124 aa)
	LOC103133374-3	Histone H4. (103 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
	polm	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (439 aa)
	ENSPFOP00000018079	Nonhomologous end-joining factor 1. (309 aa)
	LOC103154119	Endo/exonuclease/phosphatase domain-containing protein. (278 aa)
	ENSPFOP00000018038	Tyrosyl-DNA phosphodiesterase 1. (645 aa)
	rif1	Replication timing regulatory factor 1. (2356 aa)
	LOC103130469	Histone H2B; Belongs to the histone H2B family. (124 aa)
	LOC103154042	Histone H2B; Belongs to the histone H2B family. (124 aa)
	ENSPFOP00000017313	X-ray repair complementing defective repair in Chinese hamster cells 4. (343 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	LOC103129309	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ENSPFOP00000016559	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (603 aa)
	UBE2N	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
	nbn	Nibrin. (843 aa)
	LOC103133374	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	tmem182	Transmembrane protein 182a. (246 aa)
	ENSPFOP00000014388	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	ENSPFOP00000013752	Tyrosyl-DNA phosphodiesterase 2b. (363 aa)
	LOC103139193	Transmembrane protein 182b. (260 aa)
	ENSPFOP00000013426	Histone H2B; Belongs to the histone H2B family. (122 aa)
	ENSPFOP00000012111	PAX interacting (with transcription-activation domain) protein 1. (1047 aa)
	rnf169	Ring finger protein 169. (574 aa)
	kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
	LOC103132650	Tumor protein p53 binding protein, 1. (1538 aa)
	rnf168	Ring finger protein 168. (431 aa)
	ENSPFOP00000006168	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3081 aa)
	ankrd11	Ankyrin repeat domain 11. (2825 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (573 aa)
	brca1	Uncharacterized protein. (1316 aa)
	ENSPFOP00000004202	X-ray repair complementing defective repair in Chinese hamster cells 4. (322 aa)
	cnppd1	Cyclin Pas1/PHO80 domain containing 1. (430 aa)
	ENSPFOP00000003632	Nuclear receptor binding SET domain protein 2. (1301 aa)
	LOC103139909	Uncharacterized protein. (250 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	ENSPFOP00000003275	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (722 aa)
	ankrd12	Ankyrin repeat domain 12. (1822 aa)
	LOC103144613	Histone H2B; Belongs to the histone H2B family. (124 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (509 aa)
	lig4	DNA ligase. (908 aa)
	LOC103132432	Rif1_N domain-containing protein. (2175 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (722 aa)
	DNTT	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (473 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTT	ENSPFOP00000004202	ENSPFOP00000000104	ENSPFOP00000004202	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.477
DNTT	ENSPFOP00000016559	ENSPFOP00000000104	ENSPFOP00000016559	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae).	0.680
DNTT	ENSPFOP00000017313	ENSPFOP00000000104	ENSPFOP00000017313	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.477
DNTT	ENSPFOP00000018038	ENSPFOP00000000104	ENSPFOP00000018038	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Tyrosyl-DNA phosphodiesterase 1.	0.588
DNTT	ENSPFOP00000018079	ENSPFOP00000000104	ENSPFOP00000018079	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Nonhomologous end-joining factor 1.	0.705
DNTT	brca1	ENSPFOP00000000104	ENSPFOP00000004695	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Uncharacterized protein.	0.446
DNTT	cnppd1	ENSPFOP00000000104	ENSPFOP00000003707	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Cyclin Pas1/PHO80 domain containing 1.	0.590
DNTT	lig4	ENSPFOP00000000104	ENSPFOP00000000760	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA ligase.	0.897
DNTT	poll	ENSPFOP00000000104	ENSPFOP00000005165	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.645
DNTT	prkdc	ENSPFOP00000000104	ENSPFOP00000022837	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.708
DNTT	xrcc5	ENSPFOP00000000104	ENSPFOP00000000255	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.737
DNTT	xrcc6	ENSPFOP00000000104	ENSPFOP00000017257	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.813
ENSPFOP00000003275	ENSPFOP00000003632	ENSPFOP00000003275	ENSPFOP00000003632	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nuclear receptor binding SET domain protein 2.	0.762
ENSPFOP00000003275	ENSPFOP00000006168	ENSPFOP00000003275	ENSPFOP00000006168	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.996
ENSPFOP00000003275	ENSPFOP00000012111	ENSPFOP00000003275	ENSPFOP00000012111	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	PAX interacting (with transcription-activation domain) protein 1.	0.905
ENSPFOP00000003275	ENSPFOP00000013426	ENSPFOP00000003275	ENSPFOP00000013426	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Histone H2B; Belongs to the histone H2B family.	0.552
ENSPFOP00000003275	ENSPFOP00000014388	ENSPFOP00000003275	ENSPFOP00000014388	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Ubiquitin-conjugating enzyme E2 variant 2.	0.841
ENSPFOP00000003275	ENSPFOP00000016559	ENSPFOP00000003275	ENSPFOP00000016559	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae).	0.825
ENSPFOP00000003275	ENSPFOP00000018038	ENSPFOP00000003275	ENSPFOP00000018038	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Tyrosyl-DNA phosphodiesterase 1.	0.595
ENSPFOP00000003275	ENSPFOP00000020401	ENSPFOP00000003275	ENSPFOP00000020401	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Histone H2B; Belongs to the histone H2B family.	0.552