STRINGSTRING
ENSPFOP00000028950 ENSPFOP00000028950 ENSPFOP00000000215 ENSPFOP00000000215 ENSPFOP00000000479 ENSPFOP00000000479 pias4 pias4 cdca7l cdca7l LOC103144613 LOC103144613 ENSPFOP00000002331 ENSPFOP00000002331 exo1 exo1 ankrd12 ankrd12 ENSPFOP00000003275 ENSPFOP00000003275 rad50 rad50 ENSPFOP00000003632 ENSPFOP00000003632 rpa1 rpa1 brca1 brca1 exd2 exd2 hus1 hus1 LOC103142380 LOC103142380 slf1 slf1 ywhaq ywhaq blm blm ankrd11 ankrd11 rfc4 rfc4 LOC103151589 LOC103151589 recql4 recql4 rfc2 rfc2 ENSPFOP00000006168 ENSPFOP00000006168 rnf168 rnf168 tp53 tp53 LOC103132650 LOC103132650 LOC103143238 LOC103143238 LOC103148522 LOC103148522 rad1 rad1 rpa3 rpa3 LOC103142066 LOC103142066 wee1 wee1 rad9a rad9a ENSPFOP00000010038 ENSPFOP00000010038 kat5 kat5 rnf169 rnf169 ywhaz ywhaz ENSPFOP00000011005 ENSPFOP00000011005 wee2 wee2 babam1 babam1 LOC103145207 LOC103145207 chek2 chek2 rmi2 rmi2 RPA1 RPA1 cdca7 cdca7 ENSPFOP00000013426 ENSPFOP00000013426 YWHAB YWHAB ENSPFOP00000013687 ENSPFOP00000013687 rpa2 rpa2 ENSPFOP00000014359 ENSPFOP00000014359 rfc3 rfc3 ENSPFOP00000014388 ENSPFOP00000014388 ENSPFOP00000014766 ENSPFOP00000014766 rfc5 rfc5 ENSPFOP00000015340 ENSPFOP00000015340 LOC103133374 LOC103133374 ENSPFOP00000015551 ENSPFOP00000015551 CDK1 CDK1 ENSPFOP00000015636 ENSPFOP00000015636 LOC103145510 LOC103145510 nbn nbn UBE2N UBE2N LOC103129309 LOC103129309 rhno1 rhno1 LOC103134676 LOC103134676 ENSPFOP00000017410 ENSPFOP00000017410 LOC103154042 LOC103154042 LOC103130469 LOC103130469 ccnb1 ccnb1 chek1 chek1 ENSPFOP00000018931 ENSPFOP00000018931 rnf8 rnf8 topbp1 topbp1 LOC103133374-2 LOC103133374-2 LOC103133374-3 LOC103133374-3 LOC103153205 LOC103153205 ENSPFOP00000020401 ENSPFOP00000020401 ENSPFOP00000020763 ENSPFOP00000020763 LOC103144613-2 LOC103144613-2 LOC103144613-3 LOC103144613-3 LOC103133374-4 LOC103133374-4 LOC103154042-2 LOC103154042-2 ENSPFOP00000029491 ENSPFOP00000029491 LOC103154042-3 LOC103154042-3 LOC103133374-5 LOC103133374-5 ENSPFOP00000021397 ENSPFOP00000021397 ENSPFOP00000021872 ENSPFOP00000021872 ENSPFOP00000023184 ENSPFOP00000023184 ENSPFOP00000023229 ENSPFOP00000023229 tdrd3 tdrd3 ENSPFOP00000025830 ENSPFOP00000025830 LOC103130469-2 LOC103130469-2 ENSPFOP00000028055 ENSPFOP00000028055 ENSPFOP00000028108 ENSPFOP00000028108
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPFOP00000028950Reverse transcriptase domain-containing protein. (609 aa)
ENSPFOP00000000215RAD17 checkpoint clamp loader component. (627 aa)
ENSPFOP00000000479Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (253 aa)
pias4Protein inhibitor of activated STAT, 4a. (509 aa)
cdca7lCell division cycle associated 7b. (401 aa)
LOC103144613Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPFOP00000002331Abraxas 1, BRCA1 A complex subunit. (350 aa)
exo1Exonuclease 1. (769 aa)
ankrd12Ankyrin repeat domain 12. (1822 aa)
ENSPFOP00000003275Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (722 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
ENSPFOP00000003632Nuclear receptor binding SET domain protein 2. (1301 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
brca1Uncharacterized protein. (1316 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
LOC103142380RPA_C domain-containing protein. (255 aa)
slf1SMC5-SMC6 complex localization factor 1. (880 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
blmBLM RecQ like helicase. (1366 aa)
ankrd11Ankyrin repeat domain 11. (2825 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC103151589Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (250 aa)
recql4RecQ helicase-like 4. (1494 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSPFOP00000006168ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3081 aa)
rnf168Ring finger protein 168. (431 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
LOC103132650Tumor protein p53 binding protein, 1. (1538 aa)
LOC10314323814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
LOC1031485223-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
rpa3Replication protein A3. (122 aa)
LOC1031420663-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
wee1Wee1-like protein kinase. (620 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa)
ENSPFOP00000010038Rhodanese domain-containing protein. (572 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
rnf169Ring finger protein 169. (574 aa)
ywhaz14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
ENSPFOP00000011005BRISC and BRCA1 A complex member 2. (331 aa)
wee2Wee1-like protein kinase. (554 aa)
babam1BRISC and BRCA1 A complex member 1. (382 aa)
LOC10314520714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
chek2Checkpoint kinase 2. (514 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (591 aa)
cdca7Cell division cycle associated 7a. (401 aa)
ENSPFOP00000013426Histone H2B; Belongs to the histone H2B family. (122 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
ENSPFOP00000013687ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa)
rpa2Replication protein A2. (278 aa)
ENSPFOP00000014359Methionine sulfoxide reductase B1b. (471 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSPFOP00000014388Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
ENSPFOP00000014766DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (977 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSPFOP00000015340Uncharacterized protein. (1194 aa)
LOC103133374Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSPFOP00000015551Cyclin-dependent kinase 1. (302 aa)
CDK1Cyclin-dependent kinase 1. (303 aa)
ENSPFOP00000015636Cyclin-dependent kinase 1. (304 aa)
LOC10314551014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (326 aa)
nbnNibrin. (843 aa)
UBE2NUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
LOC103129309UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
rhno1Si:ch73-352p4.5. (291 aa)
LOC103134676Uncharacterized protein. (763 aa)
ENSPFOP00000017410Uncharacterized protein. (573 aa)
LOC103154042Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC103130469Histone H2B; Belongs to the histone H2B family. (124 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (401 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
ENSPFOP00000018931RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (642 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
topbp1DNA topoisomerase II binding protein 1. (1515 aa)
LOC103133374-2Histone H4. (103 aa)
LOC103133374-3Histone H4. (103 aa)
LOC103153205Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPFOP00000020401Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPFOP00000020763BRCA1/BRCA2-containing complex, subunit 3. (266 aa)
LOC103144613-2Histone H2B 1/2. (124 aa)
LOC103144613-3Histone H2B 1/2. (124 aa)
LOC103133374-4Histone H4. (103 aa)
LOC103154042-2Histone H2B 1/2-like. (124 aa)
ENSPFOP00000029491Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
LOC103154042-3Histone H2B 1/2-like. (124 aa)
LOC103133374-5Histone H4. (103 aa)
ENSPFOP00000021397Reverse transcriptase domain-containing protein. (784 aa)
ENSPFOP00000021872RAD9 checkpoint clamp component B. (369 aa)
ENSPFOP00000023184Uncharacterized protein. (679 aa)
ENSPFOP00000023229Uncharacterized protein. (235 aa)
tdrd3Tudor domain containing 3. (786 aa)
ENSPFOP00000025830Uncharacterized protein. (2090 aa)
LOC103130469-2Histone H2B 1/2-like. (124 aa)
ENSPFOP00000028055Reverse transcriptase domain-containing protein. (432 aa)
ENSPFOP00000028108Uncharacterized protein. (799 aa)
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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