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cdk4 cdk4 C7orf31 C7orf31 LOC103151709 LOC103151709 ENSPFOP00000028273 ENSPFOP00000028273 ENSPFOP00000028041 ENSPFOP00000028041 LOC103129638 LOC103129638 LOC103142242 LOC103142242 ENSPFOP00000022563 ENSPFOP00000022563 ENSPFOP00000022297 ENSPFOP00000022297 ENSPFOP00000022111 ENSPFOP00000022111 bcl2 bcl2 rprm rprm LOC103142161 LOC103142161 sesn1 sesn1 ENSPFOP00000019361 ENSPFOP00000019361 ENSPFOP00000019320 ENSPFOP00000019320 LOC103156588 LOC103156588 chek1 chek1 igf1 igf1 ccnb1 ccnb1 LOC103140595 LOC103140595 LOC103151127 LOC103151127 thbs1 thbs1 gadd45a gadd45a mdm2 mdm2 mdm4 mdm4 PPM1D PPM1D ENSPFOP00000016437 ENSPFOP00000016437 TP53I3 TP53I3 LOC103133531 LOC103133531 ENSPFOP00000015815 ENSPFOP00000015815 STEAP3 STEAP3 rrm2 rrm2 ENSPFOP00000015636 ENSPFOP00000015636 CDK1 CDK1 ENSPFOP00000015551 ENSPFOP00000015551 LOC103153446 LOC103153446 BCL2L1 BCL2L1 ENSPFOP00000015314 ENSPFOP00000015314 ENSPFOP00000015097 ENSPFOP00000015097 ENSPFOP00000015035 ENSPFOP00000015035 ei24 ei24 LOC103151557 LOC103151557 BAX BAX LOC103135166 LOC103135166 gtse1 gtse1 LOC103134329-2 LOC103134329-2 LOC103134329 LOC103134329 GADD45B-2 GADD45B-2 cop1 cop1 ENSPFOP00000013687 ENSPFOP00000013687 LOC103136130 LOC103136130 ENSPFOP00000013065 ENSPFOP00000013065 hps5 hps5 perp perp ENSPFOP00000012319 ENSPFOP00000012319 aifm2 aifm2 ENSPFOP00000012188 ENSPFOP00000012188 LOC103156310 LOC103156310 ccne1 ccne1 pidd1 pidd1 chek2 chek2 ENSPFOP00000011405 ENSPFOP00000011405 LOC103136081 LOC103136081 ccng1 ccng1 ENSPFOP00000010896 ENSPFOP00000010896 ddb2 ddb2 siva1 siva1 LOC103135859 LOC103135859 steap2 steap2 ENSPFOP00000009081 ENSPFOP00000009081 ENSPFOP00000008723 ENSPFOP00000008723 LOC103150954 LOC103150954 ccnd1 ccnd1 ENSPFOP00000008213 ENSPFOP00000008213 cdk2 cdk2 LOC103144454 LOC103144454 apaf1 apaf1 tp53 tp53 casp3 casp3 LOC103152816 LOC103152816 LOC103135050 LOC103135050 LOC103151902 LOC103151902 tsc2 tsc2 CASP3 CASP3 CCNG2 CCNG2 LOC103155804 LOC103155804 ENSPFOP00000006168 ENSPFOP00000006168 adgrb1 adgrb1 PTEN PTEN rchy1 rchy1 LOC103155286 LOC103155286 cryz cryz GADD45B GADD45B gorab gorab LOC103130706 LOC103130706 fam76b fam76b ENSPFOP00000002636 ENSPFOP00000002636 LOC103145277 LOC103145277 LOC103145274 LOC103145274 ccne2 ccne2 ENSPFOP00000002370 ENSPFOP00000002370 LOC103156621 LOC103156621 ENSPFOP00000000691 ENSPFOP00000000691 LOC103134991 LOC103134991 ENSPFOP00000000484 ENSPFOP00000000484 IGFBP3 IGFBP3 ENSPFOP00000000348 ENSPFOP00000000348 ENSPFOP00000000206 ENSPFOP00000000206
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)
C7orf31Chromosome 7 open reading frame 31. (516 aa)
LOC103151709Uncharacterized protein. (456 aa)
ENSPFOP00000028273Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (439 aa)
ENSPFOP00000028041Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (390 aa)
LOC103129638Insulin-like growth factor binding protein 3. (283 aa)
LOC103142242Uncharacterized protein. (209 aa)
ENSPFOP00000022563Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (689 aa)
ENSPFOP00000022297IlGF domain-containing protein. (180 aa)
ENSPFOP00000022111Uncharacterized protein. (306 aa)
bcl2BCL2 apoptosis regulator b. (229 aa)
rprmReprimo, TP53 dependent G2 arrest mediator candidate b. (102 aa)
LOC103142161Reprimo-like. (111 aa)
sesn1Sestrin 1. (488 aa)
ENSPFOP00000019361Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (448 aa)
ENSPFOP00000019320Zinc finger, matrin-type 3. (382 aa)
LOC103156588Cyclin G2; Belongs to the cyclin family. (330 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
igf1Insulin-like growth factor 1. (186 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (401 aa)
LOC103140595Transmembrane phosphatase with tensin homology. (512 aa)
LOC103151127Cyclin B2; Belongs to the cyclin family. (385 aa)
thbs1Thrombospondin 1b. (1171 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (162 aa)
mdm2MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (471 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (552 aa)
ENSPFOP00000016437Growth arrest and DNA-damage-inducible, alpha, b. (153 aa)
TP53I3Tumor protein p53 inducible protein 3. (367 aa)
LOC103133531Uncharacterized protein. (327 aa)
ENSPFOP00000015815Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (469 aa)
STEAP3STEAP family member 3, metalloreductase. (491 aa)
rrm2Ribonucleotide reductase M2 polypeptide. (393 aa)
ENSPFOP00000015636Cyclin-dependent kinase 1. (304 aa)
CDK1Cyclin-dependent kinase 1. (303 aa)
ENSPFOP00000015551Cyclin-dependent kinase 1. (302 aa)
LOC103153446Tetraspanin. (259 aa)
BCL2L1BCL2 like 1. (219 aa)
ENSPFOP00000015314E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
ENSPFOP00000015097Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (555 aa)
ENSPFOP00000015035Uncharacterized protein; Belongs to the peptidase C14A family. (388 aa)
ei24EI24 autophagy associated transmembrane protein. (341 aa)
LOC103151557Uncharacterized protein; Belongs to the peptidase C14A family. (456 aa)
BAXBCL2 associated X, apoptosis regulator. (191 aa)
LOC103135166Ribonucleotide reductase M2 b. (354 aa)
gtse1GTSE1_N domain-containing protein. (691 aa)
LOC103134329-2Cytochrome c-b. (105 aa)
LOC103134329Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
cop1COP1 E3 ubiquitin ligase. (698 aa)
ENSPFOP00000013687ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa)
LOC103136130Thrombospondin 1a. (1172 aa)
ENSPFOP00000013065Tetraspanin. (261 aa)
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1112 aa)
perpP53 apoptosis effector related to pmp22. (183 aa)
ENSPFOP00000012319Adhesion G protein-coupled receptor B3. (825 aa)
aifm2Apoptosis inducing factor mitochondria associated 2. (372 aa)
ENSPFOP00000012188Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (380 aa)
LOC103156310Cyclin-dependent kinase inhibitor 1D. (179 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (434 aa)
pidd1P53-induced death domain protein 1. (940 aa)
chek2Checkpoint kinase 2. (514 aa)
ENSPFOP00000011405Cyclin Dx; Belongs to the cyclin family. (295 aa)
LOC103136081Uncharacterized protein. (271 aa)
ccng1Cyclin G1; Belongs to the cyclin family. (297 aa)
ENSPFOP00000010896Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (607 aa)
ddb2Damage-specific DNA binding protein 2. (492 aa)
siva1SIVA1, apoptosis-inducing factor. (168 aa)
LOC103135859Tumor necrosis factor receptor superfamily, member a. (446 aa)
steap2STEAP family member 2, metalloreductase. (509 aa)
ENSPFOP00000009081Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1528 aa)
ENSPFOP00000008723Si:zfos-80g12.1. (431 aa)
LOC103150954Zgc:153993. (204 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
ENSPFOP00000008213Growth arrest and DNA-damage-inducible, gamma a. (161 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC103144454Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1524 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1260 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
casp3Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
LOC103152816Uncharacterized protein. (377 aa)
LOC103135050Sestrin 2. (558 aa)
LOC103151902Cytochrome c, somatic b; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
tsc2TSC complex subunit 2. (1868 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (291 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (331 aa)
LOC103155804Cyclin D2, a; Belongs to the cyclin family. (297 aa)
ENSPFOP00000006168ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3081 aa)
adgrb1Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1593 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (412 aa)
rchy1Uncharacterized protein. (278 aa)
LOC103155286Tetraspanin. (383 aa)
cryzCrystallin, zeta (quinone reductase). (328 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (173 aa)
gorabGolgin, rab6-interacting. (322 aa)
LOC103130706Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (153 aa)
fam76bFamily with sequence similarity 76 member B. (338 aa)
ENSPFOP00000002636Ribosomal_L7Ae domain-containing protein. (139 aa)
LOC103145277Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC103145274Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
ENSPFOP00000002370BH4_2 domain-containing protein. (231 aa)
LOC103156621E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (327 aa)
ENSPFOP00000000691Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (311 aa)
LOC103134991Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
ENSPFOP00000000484Cyclin-dependent kinase inhibitor 1A. (154 aa)
IGFBP3Insulin like growth factor binding protein 3. (285 aa)
ENSPFOP00000000348Cyclin D3; Belongs to the cyclin family. (311 aa)
ENSPFOP00000000206Cyclin D2, b; Belongs to the cyclin family. (296 aa)
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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