(132 nodes) Toll-like receptor signaling pathway network (Poecilia formosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103145943	C-X-C motif chemokine. (104 aa)
	ENSPFOP00000000188	Uncharacterized protein. (397 aa)
	IL12B-2	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (355 aa)
	LOC103129854	Toll-like receptor 9; Belongs to the Toll-like receptor family. (1059 aa)
	ENSPFOP00000000497	Signal transducer and activator of transcription. (749 aa)
	ENSPFOP00000000521	Zgc:158659; Belongs to the PI3/PI4-kinase family. (636 aa)
	LOC103144069	Uncharacterized protein. (474 aa)
	tlr2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (812 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (892 aa)
	ENSPFOP00000000777	Non-specific serine/threonine protein kinase. (522 aa)
	LOC103154504	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (734 aa)
	LOC103152767	Mitogen-activated protein kinase. (364 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	ENSPFOP00000001865	Uncharacterized protein. (465 aa)
	tbk1	TANK-binding kinase 1. (721 aa)
	LOC103153915	Uncharacterized protein. (268 aa)
	LOC103153916	Fibronectin type-III domain-containing protein. (460 aa)
	LOC103151778	Mitogen-activated protein kinase. (362 aa)
	LOC103151779	Mitogen-activated protein kinase. (361 aa)
	ENSPFOP00000002885	Interferon regulatory factor 3. (460 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	irf7	Interferon regulatory factor 7. (439 aa)
	ENSPFOP00000003978	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (700 aa)
	ENSPFOP00000004131	JunE proto-oncogene, AP-1 transcription factor subunit. (303 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (496 aa)
	ENSPFOP00000004443	SCY domain-containing protein. (96 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (729 aa)
	LOC103142445	SCY domain-containing protein. (97 aa)
	LOC103144386	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	LOC103134016	Mitogen-activated protein kinase. (460 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	LOC103148929	TRIF-NTD domain-containing protein. (565 aa)
	ENSPFOP00000004936	TRIF-NTD domain-containing protein. (571 aa)
	LOC103139967	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSPFOP00000005187	Zmp:0000001127. (168 aa)
	ENSPFOP00000005804	Interferon regulatory factor 6. (282 aa)
	ENSPFOP00000005811	Toll-like receptor 3; Belongs to the Toll-like receptor family. (916 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	LOC103146258	IG domain-containing protein. (296 aa)
	LOC103150965	CD40 molecule, TNF receptor superfamily member 5. (313 aa)
	LOC103134030	SCY domain-containing protein. (136 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6. (336 aa)
	ENSPFOP00000006941	Signal transducer and activator of transcription. (750 aa)
	LOC103145381	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC103134441	Interleukin-1 receptor-associated kinase 4. (462 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
	ENSPFOP00000007229	Interleukin-1 receptor-associated kinase 4. (471 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	LOC103154418	Interleukin-1. (247 aa)
	LOC103135541	Mitogen-activated protein kinase. (420 aa)
	LOC103156711	Cathepsin K; Belongs to the peptidase C1 family. (330 aa)
	ENSPFOP00000007914	Si:ch211-153j24.3. (357 aa)
	LOC103138629	V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (364 aa)
	LOC103156049	BPI fold containing family C, like. (481 aa)
	ENSPFOP00000008202	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	ENSPFOP00000008989	Toll interacting protein. (276 aa)
	ENSPFOP00000009027	Uncharacterized protein. (205 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	LOC103138778	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (491 aa)
	LOC103141944	Uncharacterized protein. (117 aa)
	LOC103140625	V-rel avian reticuloendotheliosis viral oncogene homolog A. (627 aa)
	ENSPFOP00000010151	Uncharacterized protein. (439 aa)
	LOC103151778-2	Mitogen-activated protein kinase 12-like. (362 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	ENSPFOP00000010528	SCY domain-containing protein. (92 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (211 aa)
	ENSPFOP00000011095	TIR domain-containing protein. (882 aa)
	ENSPFOP00000012041	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (303 aa)
	LOC103150707	Mitogen-activated protein kinase kinase 6. (381 aa)
	ENSPFOP00000012411	Tumor necrosis factor a (TNF superfamily, member 2); Belongs to the tumor necrosis factor family. (249 aa)
	LOC103137460	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	rel	REL proto-oncogene, NF-kB subunit. (642 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	ENSPFOP00000013438	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (290 aa)
	ENSPFOP00000013584	Interferon regulatory factor 5. (498 aa)
	ENSPFOP00000013894	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (317 aa)
	LOC103141200	Mitogen-activated protein kinase. (357 aa)
	IL12B-3	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (341 aa)
	LOC103151557	Uncharacterized protein; Belongs to the peptidase C14A family. (456 aa)
	ENSPFOP00000015035	Uncharacterized protein; Belongs to the peptidase C14A family. (388 aa)
	ENSPFOP00000015071	V-fos FBJ murine osteosarcoma viral oncogene homolog Aa. (330 aa)
	ENSPFOP00000015097	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (555 aa)
	ENSPFOP00000015347	Uncharacterized protein. (173 aa)
	LOC103143068	Uncharacterized protein. (195 aa)
	LOC103143092	Uncharacterized protein. (193 aa)
	ENSPFOP00000015630	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (703 aa)
	ENSPFOP00000015909	Uncharacterized protein. (715 aa)
	LOC103149873	Transmembrane p24 trafficking protein 3. (207 aa)
	LOC103150485	Mitogen-activated protein kinase. (368 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (583 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (735 aa)
	LOC107833139	Uncharacterized protein. (183 aa)
	LOC107833146	Uncharacterized protein. (183 aa)
	LOC107833145	Uncharacterized protein. (183 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (919 aa)
	mapk8	Mitogen-activated protein kinase. (384 aa)
	LOC103155238	Toll-like receptor 18. (874 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC103151753	Uncharacterized protein. (267 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	ENSPFOP00000019113	Transmembrane p24 trafficking protein 7. (216 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
	LOC103155249	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1074 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (96 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (111 aa)
	LOC103135488	Toll-like receptor 1. (802 aa)
	ENSPFOP00000020202	BZIP domain-containing protein; Belongs to the bZIP family. (325 aa)
	ENSPFOP00000020731	Uncharacterized protein. (648 aa)
	LOC103137045	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (324 aa)
	ENSPFOP00000022274	C-C motif chemokine. (111 aa)
	ENSPFOP00000022883	Uncharacterized protein. (217 aa)
	ENSPFOP00000023231	Protein kinase domain-containing protein. (751 aa)
	ENSPFOP00000023649	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (261 aa)
	ENSPFOP00000023757	Uncharacterized protein. (116 aa)
	irak1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (423 aa)
	LOC103144355	Mitogen-activated protein kinase. (360 aa)
	ENSPFOP00000024685	TIR domain-containing protein. (951 aa)
	ENSPFOP00000024886	SH2 domain-containing protein. (354 aa)
	ENSPFOP00000024972	C-X-C motif chemokine. (105 aa)
	ENSPFOP00000025729	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1060 aa)
	rac3	Rac family small GTPase 3b. (202 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1026 aa)
	ENSPFOP00000028532	SCY domain-containing protein. (89 aa)
	ENSPFOP00000029913	SCY domain-containing protein. (102 aa)
	ENSPFOP00000030064	Uncharacterized protein. (221 aa)
	ENSPFOP00000030648	Uncharacterized protein. (411 aa)
	ENSPFOP00000030938	annotation not available (210 aa)

Your Current Organism:

Poecilia formosa

NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPFOP00000000497	ENSPFOP00000018648	ENSPFOP00000000497	Component of inhibitor of nuclear factor kappa B kinase complex.	Signal transducer and activator of transcription.	0.607
CHUK	ENSPFOP00000000777	ENSPFOP00000018648	ENSPFOP00000000777	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase.	0.951
CHUK	ENSPFOP00000002885	ENSPFOP00000018648	ENSPFOP00000002885	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 3.	0.613
CHUK	ENSPFOP00000003978	ENSPFOP00000018648	ENSPFOP00000003978	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.967
CHUK	ENSPFOP00000004936	ENSPFOP00000018648	ENSPFOP00000004936	Component of inhibitor of nuclear factor kappa B kinase complex.	TRIF-NTD domain-containing protein.	0.569
CHUK	ENSPFOP00000005804	ENSPFOP00000018648	ENSPFOP00000005804	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 6.	0.455
CHUK	ENSPFOP00000005811	ENSPFOP00000018648	ENSPFOP00000005811	Component of inhibitor of nuclear factor kappa B kinase complex.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.536
CHUK	ENSPFOP00000006941	ENSPFOP00000018648	ENSPFOP00000006941	Component of inhibitor of nuclear factor kappa B kinase complex.	Signal transducer and activator of transcription.	0.622
CHUK	ENSPFOP00000007229	ENSPFOP00000018648	ENSPFOP00000007229	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin-1 receptor-associated kinase 4.	0.926
CHUK	ENSPFOP00000011095	ENSPFOP00000018648	ENSPFOP00000011095	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.499
CHUK	ENSPFOP00000012041	ENSPFOP00000018648	ENSPFOP00000012041	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.964
CHUK	ENSPFOP00000013438	ENSPFOP00000018648	ENSPFOP00000013438	Component of inhibitor of nuclear factor kappa B kinase complex.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.659
CHUK	ENSPFOP00000013584	ENSPFOP00000018648	ENSPFOP00000013584	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 5.	0.455
CHUK	ENSPFOP00000013894	ENSPFOP00000018648	ENSPFOP00000013894	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.964
CHUK	ENSPFOP00000015630	ENSPFOP00000018648	ENSPFOP00000015630	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.951
CHUK	ENSPFOP00000019113	ENSPFOP00000018648	ENSPFOP00000019113	Component of inhibitor of nuclear factor kappa B kinase complex.	Transmembrane p24 trafficking protein 7.	0.569
CHUK	ENSPFOP00000020731	ENSPFOP00000018648	ENSPFOP00000020731	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.426
CHUK	ENSPFOP00000022883	ENSPFOP00000018648	ENSPFOP00000022883	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.911
CHUK	ENSPFOP00000023231	ENSPFOP00000018648	ENSPFOP00000023231	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.927
CHUK	ENSPFOP00000024685	ENSPFOP00000018648	ENSPFOP00000024685	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.499