(12 nodes) Protein sumoylation network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106943827	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (102 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	pias1	Protein inhibitor of activated STAT, 1b. (656 aa)
	LOC106943710	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (509 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (646 aa)
	LOC106954174	Small ubiquitin-related modifier. (96 aa)
	LOC106957493	Small ubiquitin-related modifier. (94 aa)
	LOC106959376	Protein inhibitor of activated STAT, 1a. (677 aa)
	ENSPLAP00000019823	SP-RING-type domain-containing protein. (114 aa)
	sae1	SUMO1 activating enzyme subunit 1. (345 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000019823	LOC106943710	ENSPLAP00000019823	ENSPLAP00000007208	SP-RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.855
ENSPLAP00000019823	LOC106943827	ENSPLAP00000019823	ENSPLAP00000003069	SP-RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.855
ENSPLAP00000019823	LOC106954174	ENSPLAP00000019823	ENSPLAP00000012403	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.846
ENSPLAP00000019823	LOC106957493	ENSPLAP00000019823	ENSPLAP00000013531	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.846
ENSPLAP00000019823	LOC106959376	ENSPLAP00000019823	ENSPLAP00000017238	SP-RING-type domain-containing protein.	Protein inhibitor of activated STAT, 1a.	0.680
ENSPLAP00000019823	pias1	ENSPLAP00000019823	ENSPLAP00000005722	SP-RING-type domain-containing protein.	Protein inhibitor of activated STAT, 1b.	0.905
ENSPLAP00000019823	pias4	ENSPLAP00000019823	ENSPLAP00000007655	SP-RING-type domain-containing protein.	Protein inhibitor of activated STAT, 4a.	0.905
ENSPLAP00000019823	sae1	ENSPLAP00000019823	ENSPLAP00000019988	SP-RING-type domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.527
ENSPLAP00000019823	sumo1	ENSPLAP00000019823	ENSPLAP00000029447	SP-RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.950
ENSPLAP00000019823	uba2	ENSPLAP00000019823	ENSPLAP00000012391	SP-RING-type domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.517
ENSPLAP00000019823	ube2i	ENSPLAP00000019823	ENSPLAP00000004940	SP-RING-type domain-containing protein.	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family.	0.855
LOC106943710	ENSPLAP00000019823	ENSPLAP00000007208	ENSPLAP00000019823	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	SP-RING-type domain-containing protein.	0.855
LOC106943710	LOC106954174	ENSPLAP00000007208	ENSPLAP00000012403	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.972
LOC106943710	LOC106957493	ENSPLAP00000007208	ENSPLAP00000013531	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.972
LOC106943710	LOC106959376	ENSPLAP00000007208	ENSPLAP00000017238	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT, 1a.	0.855
LOC106943710	pias1	ENSPLAP00000007208	ENSPLAP00000005722	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT, 1b.	0.855
LOC106943710	pias4	ENSPLAP00000007208	ENSPLAP00000007655	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT, 4a.	0.900
LOC106943710	sae1	ENSPLAP00000007208	ENSPLAP00000019988	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	SUMO1 activating enzyme subunit 1.	0.963
LOC106943710	sumo1	ENSPLAP00000007208	ENSPLAP00000029447	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.993
LOC106943710	uba2	ENSPLAP00000007208	ENSPLAP00000012391	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.974