(30 nodes) Fanconi Anemia Pathway, and DDE transposase retroviral integrase sub-family network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fancc	FA complementation group C. (578 aa)
	LOC106943851	Uncharacterized protein. (360 aa)
	nars1	Asparaginyl-tRNA synthetase. (559 aa)
	fancl	FA complementation group L. (371 aa)
	ENSPLAP00000006383	Uncharacterized protein. (273 aa)
	fancf	FA complementation group F. (343 aa)
	ENSPLAP00000007715	Integrase catalytic domain-containing protein. (373 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (629 aa)
	fanci	FA complementation group I. (1246 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (944 aa)
	ENSPLAP00000010560	Centromere protein X. (63 aa)
	fancd2	FA complementation group D2. (1388 aa)
	ENSPLAP00000012516	Integrase catalytic domain-containing protein. (340 aa)
	LOC106956439	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa)
	LOC106956690	NTF2 domain-containing protein. (130 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (511 aa)
	ENSPLAP00000016343	Integrase catalytic domain-containing protein. (409 aa)
	ercc1	Excision repair cross-complementation group 1. (356 aa)
	faap24	FA core complex associated protein 24. (219 aa)
	faap100	Si:dkey-57h18.1. (818 aa)
	LOC106946659	Ubiquitin-conjugating enzyme E2T (putative). (220 aa)
	fancg	FA complementation group G. (618 aa)
	ENSPLAP00000022536	Integrase catalytic domain-containing protein. (227 aa)
	CENPS	Centromere protein S. (150 aa)
	fance	FA complementation group E. (524 aa)
	nutf2	Nuclear transport factor 2. (127 aa)
	EME2	ERCC4 domain-containing protein. (436 aa)
	fanca	Fanconi_A_N domain-containing protein. (1391 aa)
	dclre1a	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (907 aa)
	ercc4	Excision repair cross-complementation group 4. (888 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPS	EME2	ENSPLAP00000023263	ENSPLAP00000028618	Centromere protein S.	ERCC4 domain-containing protein.	0.452
CENPS	ENSPLAP00000006383	ENSPLAP00000023263	ENSPLAP00000006383	Centromere protein S.	Uncharacterized protein.	0.524
CENPS	ENSPLAP00000007715	ENSPLAP00000023263	ENSPLAP00000007715	Centromere protein S.	Integrase catalytic domain-containing protein.	0.524
CENPS	ENSPLAP00000010560	ENSPLAP00000023263	ENSPLAP00000010560	Centromere protein S.	Centromere protein X.	0.824
CENPS	ENSPLAP00000012516	ENSPLAP00000023263	ENSPLAP00000012516	Centromere protein S.	Integrase catalytic domain-containing protein.	0.524
CENPS	ENSPLAP00000016343	ENSPLAP00000023263	ENSPLAP00000016343	Centromere protein S.	Integrase catalytic domain-containing protein.	0.524
CENPS	ENSPLAP00000022536	ENSPLAP00000023263	ENSPLAP00000022536	Centromere protein S.	Integrase catalytic domain-containing protein.	0.524
CENPS	LOC106943851	ENSPLAP00000023263	ENSPLAP00000002993	Centromere protein S.	Uncharacterized protein.	0.974
CENPS	LOC106946659	ENSPLAP00000023263	ENSPLAP00000019591	Centromere protein S.	Ubiquitin-conjugating enzyme E2T (putative).	0.829
CENPS	LOC106956439	ENSPLAP00000023263	ENSPLAP00000014302	Centromere protein S.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.420
CENPS	LOC106956690	ENSPLAP00000023263	ENSPLAP00000015218	Centromere protein S.	NTF2 domain-containing protein.	0.837
CENPS	dclre1a	ENSPLAP00000023263	ENSPLAP00000030192	Centromere protein S.	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).	0.514
CENPS	eme1	ENSPLAP00000023263	ENSPLAP00000015961	Centromere protein S.	Essential meiotic structure-specific endonuclease 1.	0.534
CENPS	ercc1	ENSPLAP00000023263	ENSPLAP00000017639	Centromere protein S.	Excision repair cross-complementation group 1.	0.783
CENPS	ercc4	ENSPLAP00000023263	ENSPLAP00000031014	Centromere protein S.	Excision repair cross-complementation group 4.	0.842
CENPS	faap100	ENSPLAP00000023263	ENSPLAP00000018237	Centromere protein S.	Si:dkey-57h18.1.	0.959
CENPS	faap24	ENSPLAP00000023263	ENSPLAP00000018226	Centromere protein S.	FA core complex associated protein 24.	0.983
CENPS	fan1	ENSPLAP00000023263	ENSPLAP00000009705	Centromere protein S.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.460
CENPS	fanca	ENSPLAP00000023263	ENSPLAP00000030106	Centromere protein S.	Fanconi_A_N domain-containing protein.	0.972
CENPS	fancc	ENSPLAP00000023263	ENSPLAP00000000609	Centromere protein S.	FA complementation group C.	0.976