(29 nodes) Mixed, incl. Exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases, and DNA-directed DNA polymerase, family A, palm domain network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gatc	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (185 aa)
	rexo1	REX1, RNA exonuclease 1 homolog. (1237 aa)
	REXO2	RNA exonuclease 2. (259 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (770 aa)
	pan2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1206 aa)
	ENSPLAP00000007633	Zmp:0000000984. (384 aa)
	neil3	Nei-like DNA glycosylase 3. (577 aa)
	twnk	Twinkle mtDNA helicase. (721 aa)
	LOC106935550	RNase H domain-containing protein. (181 aa)
	helq	Helicase, POLQ like. (1020 aa)
	trnt1	tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (427 aa)
	LOC106957561	Zgc:194209. (339 aa)
	rnaseh2a	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (255 aa)
	LOC106935437	Uncharacterized protein. (651 aa)
	fdxacb1	Ferredoxin-fold anticodon binding domain containing 1. (632 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1059 aa)
	ssbp1	Single-stranded DNA binding protein 1. (147 aa)
	LOC106952920	Exonuclease domain-containing protein. (1076 aa)
	LOC106961171	Interferon stimulated exonuclease gene. (352 aa)
	REXO5	RNA exonuclease 5. (809 aa)
	ENSPLAP00000022353	Uncharacterized protein. (223 aa)
	apmap	Adipocyte plasma membrane associated protein. (309 aa)
	polg	Polymerase (DNA directed), gamma. (1168 aa)
	supv3l1	SUV3-like helicase. (780 aa)
	polg2	Polymerase (DNA directed), gamma 2, accessory subunit. (444 aa)
	pan3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (792 aa)
	ENSPLAP00000030353	Uncharacterized protein. (245 aa)
	poln	Uncharacterized protein. (965 aa)
	polq	Polymerase (DNA directed), theta. (2354 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000007633	ENSPLAP00000022353	ENSPLAP00000007633	ENSPLAP00000022353	Zmp:0000000984.	Uncharacterized protein.	0.417
ENSPLAP00000007633	LOC106935437	ENSPLAP00000007633	ENSPLAP00000013860	Zmp:0000000984.	Uncharacterized protein.	0.595
ENSPLAP00000007633	LOC106952920	ENSPLAP00000007633	ENSPLAP00000021342	Zmp:0000000984.	Exonuclease domain-containing protein.	0.417
ENSPLAP00000007633	LOC106957561	ENSPLAP00000007633	ENSPLAP00000012407	Zmp:0000000984.	Zgc:194209.	0.659
ENSPLAP00000007633	LOC106961171	ENSPLAP00000007633	ENSPLAP00000021826	Zmp:0000000984.	Interferon stimulated exonuclease gene.	0.417
ENSPLAP00000007633	PNPT1	ENSPLAP00000007633	ENSPLAP00000006720	Zmp:0000000984.	Polyribonucleotide nucleotidyltransferase 1.	0.659
ENSPLAP00000007633	REXO5	ENSPLAP00000007633	ENSPLAP00000022115	Zmp:0000000984.	RNA exonuclease 5.	0.417
ENSPLAP00000007633	apmap	ENSPLAP00000007633	ENSPLAP00000023712	Zmp:0000000984.	Adipocyte plasma membrane associated protein.	0.659
ENSPLAP00000007633	pan2	ENSPLAP00000007633	ENSPLAP00000006920	Zmp:0000000984.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.417
ENSPLAP00000007633	rexo1	ENSPLAP00000007633	ENSPLAP00000004651	Zmp:0000000984.	REX1, RNA exonuclease 1 homolog.	0.417
ENSPLAP00000022353	ENSPLAP00000007633	ENSPLAP00000022353	ENSPLAP00000007633	Uncharacterized protein.	Zmp:0000000984.	0.417
ENSPLAP00000022353	ENSPLAP00000030353	ENSPLAP00000022353	ENSPLAP00000030353	Uncharacterized protein.	Uncharacterized protein.	0.569
ENSPLAP00000022353	LOC106935437	ENSPLAP00000022353	ENSPLAP00000013860	Uncharacterized protein.	Uncharacterized protein.	0.611
ENSPLAP00000022353	LOC106935550	ENSPLAP00000022353	ENSPLAP00000011779	Uncharacterized protein.	RNase H domain-containing protein.	0.569
ENSPLAP00000022353	LOC106957561	ENSPLAP00000022353	ENSPLAP00000012407	Uncharacterized protein.	Zgc:194209.	0.675
ENSPLAP00000022353	PNPT1	ENSPLAP00000022353	ENSPLAP00000006720	Uncharacterized protein.	Polyribonucleotide nucleotidyltransferase 1.	0.675
ENSPLAP00000022353	REXO2	ENSPLAP00000022353	ENSPLAP00000005420	Uncharacterized protein.	RNA exonuclease 2.	0.737
ENSPLAP00000022353	apmap	ENSPLAP00000022353	ENSPLAP00000023712	Uncharacterized protein.	Adipocyte plasma membrane associated protein.	0.675
ENSPLAP00000022353	dis3l2	ENSPLAP00000022353	ENSPLAP00000016800	Uncharacterized protein.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily.	0.655
ENSPLAP00000022353	helq	ENSPLAP00000022353	ENSPLAP00000011982	Uncharacterized protein.	Helicase, POLQ like.	0.610