(27 nodes) Mixed, incl. IRAK2 mediated activation of TAK1 complex, and TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	tank	TRAF family member-associated NFKB activator. (336 aa)
	LOC106953890	Mitogen-activated protein kinase kinase kinase 14a. (871 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (378 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (567 aa)
	birc2	Baculoviral IAP repeat containing 2. (642 aa)
	LOC106947210	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (599 aa)
	ENSPLAP00000007568	Uncharacterized protein. (87 aa)
	LOC106965283	Interleukin 1 receptor associated kinase 4. (462 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	LOC106956448	Tumor necrosis factor receptor superfamily, member 1B. (408 aa)
	LOC106951689	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (491 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (573 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	LOC106952743	TIR domain-containing protein. (931 aa)
	LOC106956159	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (629 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (496 aa)
	LOC106960027	Si:ch211-112c15.8. (394 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (742 aa)
	LOC106943863	Pleckstrin homology domain containing, family G (with RhoGef domain) member 5b. (431 aa)
	birc7	RING-type domain-containing protein. (372 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (735 aa)
	LOC106961734	Sterile alpha motif and leucine zipper containing kinase AZK. (775 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	map3k20	Protein kinase domain-containing protein. (423 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (518 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPLAP00000007568	ENSPLAP00000027807	ENSPLAP00000007568	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.835
CHUK	LOC106943863	ENSPLAP00000027807	ENSPLAP00000020937	Component of inhibitor of nuclear factor kappa B kinase complex.	Pleckstrin homology domain containing, family G (with RhoGef domain) member 5b.	0.748
CHUK	LOC106947210	ENSPLAP00000027807	ENSPLAP00000006980	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.731
CHUK	LOC106951689	ENSPLAP00000027807	ENSPLAP00000009795	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.956
CHUK	LOC106952743	ENSPLAP00000027807	ENSPLAP00000015073	Component of inhibitor of nuclear factor kappa B kinase complex.	TIR domain-containing protein.	0.465
CHUK	LOC106953890	ENSPLAP00000027807	ENSPLAP00000000248	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 14a.	0.975
CHUK	LOC106956159	ENSPLAP00000027807	ENSPLAP00000015617	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.731
CHUK	LOC106960027	ENSPLAP00000027807	ENSPLAP00000018852	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:ch211-112c15.8.	0.748
CHUK	LOC106961734	ENSPLAP00000027807	ENSPLAP00000025722	Component of inhibitor of nuclear factor kappa B kinase complex.	Sterile alpha motif and leucine zipper containing kinase AZK.	0.816
CHUK	LOC106965283	ENSPLAP00000027807	ENSPLAP00000007637	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin 1 receptor associated kinase 4.	0.929
CHUK	birc2	ENSPLAP00000027807	ENSPLAP00000006186	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat containing 2.	0.701
CHUK	birc7	ENSPLAP00000027807	ENSPLAP00000022049	Component of inhibitor of nuclear factor kappa B kinase complex.	RING-type domain-containing protein.	0.701
CHUK	ikbkb	ENSPLAP00000027807	ENSPLAP00000013328	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.932
CHUK	ikbke	ENSPLAP00000027807	ENSPLAP00000025145	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.424
CHUK	ikbkg	ENSPLAP00000027807	ENSPLAP00000005337	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.980
CHUK	map3k20	ENSPLAP00000027807	ENSPLAP00000026634	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.816
CHUK	tab1	ENSPLAP00000027807	ENSPLAP00000016221	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.965
CHUK	tab2	ENSPLAP00000027807	ENSPLAP00000019243	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.969
CHUK	tab3	ENSPLAP00000027807	ENSPLAP00000009912	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.950
CHUK	tank	ENSPLAP00000027807	ENSPLAP00000000154	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NFKB activator.	0.695