STRINGSTRING
smad9 smad9 bambi bambi tgfbr3 tgfbr3 hpgd hpgd LOC106936703 LOC106936703 appl2 appl2 ENSPLAP00000023965 ENSPLAP00000023965 skil skil tgfb3 tgfb3 jun jun SMAD3 SMAD3 lrrc32 lrrc32 flcn flcn mstn mstn smad1 smad1 cited1 cited1 LOC106944326 LOC106944326 LOC106959281 LOC106959281 LOC106940894 LOC106940894 appl1 appl1 nlk nlk LOC106938824 LOC106938824 LOC106958271 LOC106958271 LOC106955751 LOC106955751 smad7 smad7 LOC106953020 LOC106953020 sirt1 sirt1 smad3 smad3 LOC106934411 LOC106934411 LOC106939239 LOC106939239 LOC106957970 LOC106957970 LOC106947507 LOC106947507 LOC106953209 LOC106953209 tgfb2 tgfb2 LOC106937460 LOC106937460 LOC106940523 LOC106940523 TGFBR2 TGFBR2 LOC106939787 LOC106939787 tab1 tab1 LOC106963015 LOC106963015 nrros nrros LOC106942461 LOC106942461 LOC106961670 LOC106961670 LOC106954227 LOC106954227 smad6 smad6 itgb6 itgb6 LOC106959732 LOC106959732 ENSPLAP00000025080 ENSPLAP00000025080 LOC106949081 LOC106949081 LOC106954704 LOC106954704 acvr1 acvr1 usp9x usp9x fut8 fut8 cldn5 cldn5 itgb8 itgb8 LOC106956726 LOC106956726
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smad9Mothers against decapentaplegic homolog. (467 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
tgfbr3Transforming growth factor, beta receptor III. (730 aa)
hpgd15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
LOC106936703Transforming growth factor beta; Belongs to the TGF-beta family. (399 aa)
appl2Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (665 aa)
ENSPLAP00000023965Uncharacterized protein. (80 aa)
skilSKI-like proto-oncogene a. (770 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (288 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
lrrc32Leucine rich repeat containing 32. (655 aa)
flcnFolliculin. (554 aa)
mstnMyostatin b. (375 aa)
smad1Mothers against decapentaplegic homolog. (467 aa)
cited1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (152 aa)
LOC106944326Mothers against decapentaplegic homolog. (503 aa)
LOC106959281Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
LOC106940894Mothers against decapentaplegic homolog. (464 aa)
appl1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (678 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
LOC106938824Mothers against decapentaplegic homolog. (474 aa)
LOC106958271Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
LOC106955751Zyxin. (608 aa)
smad7Mothers against decapentaplegic homolog. (364 aa)
LOC106953020Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
sirt1Sirtuin 1. (677 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC106934411Mothers against decapentaplegic homolog. (467 aa)
LOC106939239Mothers against decapentaplegic homolog. (534 aa)
LOC106957970Mothers against decapentaplegic homolog. (475 aa)
LOC106947507Transforming growth factor beta; Belongs to the TGF-beta family. (373 aa)
LOC106953209Golgi glycoprotein 1b. (1146 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOC106937460Mothers against decapentaplegic homolog. (510 aa)
LOC106940523Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
LOC106939787Uncharacterized protein. (1147 aa)
tab1TGF-beta activated kinase 1/MAP3K7 binding protein 1. (496 aa)
LOC106963015Fucosyltransferase 8b (alpha (1,6) fucosyltransferase); Belongs to the glycosyltransferase 23 family. (305 aa)
nrrosNegative regulator of reactive oxygen species. (685 aa)
LOC106942461Myostatin a. (363 aa)
LOC106961670Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
LOC106954227TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
smad6Mothers against decapentaplegic homolog. (490 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (780 aa)
LOC106959732Mothers against decapentaplegic homolog. (332 aa)
ENSPLAP00000025080Uncharacterized protein. (562 aa)
LOC106949081Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC106954704Growth differentiation factor 11. (402 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (691 aa)
usp9xUbiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2567 aa)
fut8Fucosyltransferase 8b (alpha (1,6) fucosyltransferase); Belongs to the glycosyltransferase 23 family. (391 aa)
cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (671 aa)
LOC106956726JunE proto-oncogene, AP-1 transcription factor subunit. (323 aa)
Your Current Organism:
Poecilia latipinna
NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.