(51 nodes) Regulation of cellular ketone metabolic process network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106947837	Nuclear receptor subfamily 1, group H, member 5. (477 aa)
	ENSPLAP00000000767	Fumarate hydratase. (482 aa)
	LOC106948620	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (312 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (521 aa)
	etfbkmt	Electron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	ENSPLAP00000002952	ATCAY kinesin light chain interacting caytaxin b. (330 aa)
	LOC106947926	Dickkopf WNT signaling pathway inhibitor 3a. (295 aa)
	pdk3	Protein-serine/threonine kinase. (407 aa)
	LOC106940222	Tribbles pseudokinase 3. (351 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (765 aa)
	sirt1	Sirtuin 1. (677 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (318 aa)
	LOC106959087	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	brca1	Uncharacterized protein. (1315 aa)
	LOC106935033	Nuclear receptor subfamily 1, group d, member 1. (565 aa)
	LOC106945259	Si:ch73-352p4.8. (458 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	ncor2	Nuclear receptor corepressor 2. (2249 aa)
	PPTC7	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	LOC106947649	Nuclear receptor subfamily 1, group D, member 4a. (580 aa)
	LOC106940909	Solute carrier family 7 member 11. (241 aa)
	abcd2	ATP-binding cassette, sub-family D (ALD), member 2. (754 aa)
	LOC106941220	Uncharacterized protein. (490 aa)
	LOC106950393	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (204 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (459 aa)
	dab2	DAB adaptor protein 2. (737 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (476 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	MTLN	Mitoregulin. (56 aa)
	cln3	Battenin. (444 aa)
	LOC106946048	Tribbles homolog 2-like. (351 aa)
	LOC106940496	Interleukin-1. (247 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (372 aa)
	DGKQ	Diacylglycerol kinase. (887 aa)
	coq3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (338 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3b. (259 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
	pdk4	Protein-serine/threonine kinase. (410 aa)
	scap	SREBF chaperone. (1264 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (508 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	mlycd	Malonyl-CoA decarboxylase. (504 aa)
	LOC106938521	ATCAY kinesin light chain interacting caytaxin a. (370 aa)
	pdk1	Protein-serine/threonine kinase. (407 aa)
	ENSPLAP00000029324	GPS2_interact domain-containing protein. (223 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	LOC106945413	Protein-serine/threonine kinase. (408 aa)
	ENSPLAP00000030918	Uncharacterized protein. (423 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (668 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DGKQ	lpgat1	ENSPLAP00000019021	ENSPLAP00000018828	Diacylglycerol kinase.	Lysophosphatidylglycerol acyltransferase 1.	0.455
ENSPLAP00000000767	LOC106940909	ENSPLAP00000000767	ENSPLAP00000009991	Fumarate hydratase.	Solute carrier family 7 member 11.	0.419
ENSPLAP00000000767	LOC106945259	ENSPLAP00000000767	ENSPLAP00000009160	Fumarate hydratase.	Si:ch73-352p4.8.	0.419
ENSPLAP00000000767	h6pd	ENSPLAP00000000767	ENSPLAP00000023248	Fumarate hydratase.	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).	0.677
ENSPLAP00000029324	ENSPLAP00000030918	ENSPLAP00000029324	ENSPLAP00000030918	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.947
ENSPLAP00000029324	LOC106935033	ENSPLAP00000029324	ENSPLAP00000008701	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1, group d, member 1.	0.880
ENSPLAP00000029324	LOC106941220	ENSPLAP00000029324	ENSPLAP00000010114	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.822
ENSPLAP00000029324	LOC106947649	ENSPLAP00000029324	ENSPLAP00000009838	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1, group D, member 4a.	0.880
ENSPLAP00000029324	LOC106947837	ENSPLAP00000029324	ENSPLAP00000022273	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1, group H, member 5.	0.872
ENSPLAP00000029324	LOC106948620	ENSPLAP00000029324	ENSPLAP00000001052	GPS2_interact domain-containing protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.527
ENSPLAP00000029324	PPARA	ENSPLAP00000029324	ENSPLAP00000002432	GPS2_interact domain-containing protein.	Peroxisome proliferator-activated receptor alpha b.	0.843
ENSPLAP00000029324	PPARG	ENSPLAP00000029324	ENSPLAP00000012995	GPS2_interact domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.843
ENSPLAP00000029324	nr1h3	ENSPLAP00000029324	ENSPLAP00000014820	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1, group H, member 3.	0.879
ENSPLAP00000029324	nr1h4	ENSPLAP00000029324	ENSPLAP00000012122	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1, group H, member 4.	0.872
ENSPLAP00000029324	ppard	ENSPLAP00000029324	ENSPLAP00000026022	GPS2_interact domain-containing protein.	Peroxisome proliferator-activated receptor delta b.	0.839
ENSPLAP00000029324	sirt1	ENSPLAP00000029324	ENSPLAP00000005614	GPS2_interact domain-containing protein.	Sirtuin 1.	0.776
ENSPLAP00000029324	sirt5	ENSPLAP00000029324	ENSPLAP00000006645	GPS2_interact domain-containing protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.527
ENSPLAP00000030918	ENSPLAP00000029324	ENSPLAP00000030918	ENSPLAP00000029324	Uncharacterized protein.	GPS2_interact domain-containing protein.	0.947
ENSPLAP00000030918	LOC106935033	ENSPLAP00000030918	ENSPLAP00000008701	Uncharacterized protein.	Nuclear receptor subfamily 1, group d, member 1.	0.880
ENSPLAP00000030918	LOC106941220	ENSPLAP00000030918	ENSPLAP00000010114	Uncharacterized protein.	Uncharacterized protein.	0.822