(79 nodes) RNA polymerase II, holoenzyme network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	polr2m	RNA polymerase II subunit M. (332 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	LOC106935944	B30.2/SPRY domain-containing protein. (694 aa)
	LOC106953745	Cyclin H; Belongs to the cyclin family. (318 aa)
	supt3h	Uncharacterized protein. (361 aa)
	LOC106951216	WD repeat domain 61. (305 aa)
	LOC106953272	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (818 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	LOC106954525	Regulation of nuclear pre-mRNA domain containing 1A. (294 aa)
	LOC106938892	Si:dkey-219c3.2. (921 aa)
	rpap2	RNA polymerase II associated protein 2. (591 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	gtf2b	General transcription factor IIB. (318 aa)
	taf13	TATA-box binding protein associated factor 13. (125 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1907 aa)
	ENSPLAP00000005771	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (157 aa)
	ENSPLAP00000005858	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (374 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (662 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
	taf11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (206 aa)
	LOC106957028	General transcription factor IIA, 1-like. (430 aa)
	LOC106943640	General transcription factor IIH, polypeptide 2. (275 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	myo6	Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1289 aa)
	LOC106957710	TAFH domain-containing protein. (692 aa)
	LOC106950291	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (255 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	tbp	TATA box binding protein. (304 aa)
	taf5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (782 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (312 aa)
	gtf2e1	General transcription factor IIE, polypeptide 1, alpha. (447 aa)
	pex2	Peroxisomal biogenesis factor 2. (334 aa)
	LOC106959575	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (637 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (186 aa)
	taf6l	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (639 aa)
	LOC106955458	Regulation of nuclear pre-mRNA domain containing 2b. (1171 aa)
	taf2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1217 aa)
	rprd2	Regulation of nuclear pre-mRNA domain containing 2a. (1077 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
	recql5	RecQ helicase-like 5. (1012 aa)
	ENSPLAP00000016416	TAF4 domain-containing protein. (283 aa)
	taf5l	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (601 aa)
	paf1	PAF1 homolog, Paf1/RNA polymerase II complex component. (530 aa)
	ercc3	Excision repair cross-complementation group 3. (771 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (532 aa)
	LOC106953350	Transcription initiation factor TFIID subunit. (1827 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (177 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	rtf1	RTF1 homolog, Paf1/RNA polymerase II complex component. (673 aa)
	taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (306 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	ENSPLAP00000020248	Uncharacterized protein. (68 aa)
	LOC106939460	B30.2/SPRY domain-containing protein. (690 aa)
	LOC106938866	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (247 aa)
	TAF4	TATA-box binding protein associated factor 4. (856 aa)
	taf7	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (368 aa)
	ENSPLAP00000024302	Uncharacterized protein. (284 aa)
	LOC106959106	Transcription initiation factor TFIID subunit 4-like. (921 aa)
	ENSPLAP00000024369	B30.2/SPRY domain-containing protein. (701 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	ENSPLAP00000025105	Uncharacterized protein. (579 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (419 aa)
	ENSPLAP00000025116	Transformation/transcription domain-associated protein. (1807 aa)
	mnat1	MNAT1 component of CDK activating kinase. (296 aa)
	LOC106939932	Transcription initiation factor TFIID subunit 6-like. (637 aa)
	LOC106956922	General transcription factor IIA, 1. (393 aa)
	rprd1b	Regulation of nuclear pre-mRNA domain containing 1B. (328 aa)
	ENSPLAP00000028220	Uncharacterized protein. (94 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (300 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1154 aa)
	gtf2e2	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (287 aa)
	taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (941 aa)
	LOC106941339	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1052 aa)
	gtf2a2	General transcription factor IIA, 2. (119 aa)
	LOC106943114	General transcription factor IIH, polypeptide 2. (181 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000005771	ENSPLAP00000005858	ENSPLAP00000005771	ENSPLAP00000005858	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.965
ENSPLAP00000005771	ENSPLAP00000016416	ENSPLAP00000005771	ENSPLAP00000016416	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF4 domain-containing protein.	0.961
ENSPLAP00000005771	ENSPLAP00000020248	ENSPLAP00000005771	ENSPLAP00000020248	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Uncharacterized protein.	0.921
ENSPLAP00000005771	ENSPLAP00000024302	ENSPLAP00000005771	ENSPLAP00000024302	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Uncharacterized protein.	0.974
ENSPLAP00000005771	ENSPLAP00000025105	ENSPLAP00000005771	ENSPLAP00000025105	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Uncharacterized protein.	0.965
ENSPLAP00000005771	ENSPLAP00000025116	ENSPLAP00000005771	ENSPLAP00000025116	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transformation/transcription domain-associated protein.	0.965
ENSPLAP00000005771	ENSPLAP00000028220	ENSPLAP00000005771	ENSPLAP00000028220	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Uncharacterized protein.	0.874
ENSPLAP00000005771	LOC106938866	ENSPLAP00000005771	ENSPLAP00000021256	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSPLAP00000005771	LOC106938892	ENSPLAP00000005771	ENSPLAP00000002977	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Si:dkey-219c3.2.	0.961
ENSPLAP00000005771	LOC106939932	ENSPLAP00000005771	ENSPLAP00000025524	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transcription initiation factor TFIID subunit 6-like.	0.991
ENSPLAP00000005771	LOC106943114	ENSPLAP00000005771	ENSPLAP00000031579	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	General transcription factor IIH, polypeptide 2.	0.874
ENSPLAP00000005771	LOC106943640	ENSPLAP00000005771	ENSPLAP00000007711	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	General transcription factor IIH, polypeptide 2.	0.874
ENSPLAP00000005771	LOC106950291	ENSPLAP00000005771	ENSPLAP00000009557	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.907
ENSPLAP00000005771	LOC106951216	ENSPLAP00000005771	ENSPLAP00000001239	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	WD repeat domain 61.	0.616
ENSPLAP00000005771	LOC106953272	ENSPLAP00000005771	ENSPLAP00000001419	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.961
ENSPLAP00000005771	LOC106953350	ENSPLAP00000005771	ENSPLAP00000017972	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transcription initiation factor TFIID subunit.	0.999
ENSPLAP00000005771	LOC106953745	ENSPLAP00000005771	ENSPLAP00000000607	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Cyclin H; Belongs to the cyclin family.	0.867
ENSPLAP00000005771	LOC106956922	ENSPLAP00000005771	ENSPLAP00000025597	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	General transcription factor IIA, 1.	0.961
ENSPLAP00000005771	LOC106957028	ENSPLAP00000005771	ENSPLAP00000007231	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	General transcription factor IIA, 1-like.	0.903
ENSPLAP00000005771	LOC106957710	ENSPLAP00000005771	ENSPLAP00000009314	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAFH domain-containing protein.	0.961