(31 nodes) Endoribonuclease activity, producing 5-phosphomonoesters network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dicer1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1883 aa)
	ENSPLAP00000024335	Uncharacterized protein. (96 aa)
	ttc38	Tetratricopeptide repeat domain 38. (466 aa)
	pop5	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (167 aa)
	pld6	Phospholipase D family, member 6. (211 aa)
	ENSPLAP00000026969	Lactamase_B_4 domain-containing protein. (273 aa)
	ENSPLAP00000011922	ElaC ribonuclease Z 2. (466 aa)
	LOC106935550	RNase H domain-containing protein. (181 aa)
	nudt12	Nudix (nucleoside diphosphate linked moiety X)-type motif 12. (460 aa)
	dbr1	Debranching RNA lariats 1. (538 aa)
	LOC106959852	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (868 aa)
	rpp38	Ribonuclease P/MRP 38 subunit. (283 aa)
	ENSPLAP00000003414	Ribonuclease P and MRP subunit p25, b. (222 aa)
	POP1	POP1 homolog, ribonuclease P/MRP subunit. (958 aa)
	LOC106944611	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
	LOC106950561	DBR1 domain-containing protein. (373 aa)
	elac1	ElaC ribonuclease Z 1. (372 aa)
	ENSPLAP00000030353	Uncharacterized protein. (245 aa)
	drosha	Uncharacterized protein. (1313 aa)
	rnaseh2a	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (255 aa)
	LOC106946899	Uncharacterized protein; Belongs to the argonaute family. (770 aa)
	LOC106958625	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (229 aa)
	prorp	Protein only RNase P catalytic subunit. (593 aa)
	rpp14	Ribonuclease P/MRP 14 subunit. (125 aa)
	rpp40	Ribonuclease P/MRP 40 subunit. (348 aa)
	LOC106944612	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	pop4	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (222 aa)
	LOC106964788	Zgc:110269. (351 aa)
	rpp30	Ribonuclease P/MRP 30 subunit. (285 aa)
	LOC106955778	Ribonuclease P 21 subunit. (157 aa)
	pop7	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (151 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000003414	LOC106955778	ENSPLAP00000003414	ENSPLAP00000021624	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P 21 subunit.	0.998
ENSPLAP00000003414	POP1	ENSPLAP00000003414	ENSPLAP00000003217	Ribonuclease P and MRP subunit p25, b.	POP1 homolog, ribonuclease P/MRP subunit.	0.997
ENSPLAP00000003414	pop4	ENSPLAP00000003414	ENSPLAP00000020345	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.998
ENSPLAP00000003414	pop5	ENSPLAP00000003414	ENSPLAP00000026352	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.998
ENSPLAP00000003414	pop7	ENSPLAP00000003414	ENSPLAP00000022841	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.979
ENSPLAP00000003414	prorp	ENSPLAP00000003414	ENSPLAP00000017770	Ribonuclease P and MRP subunit p25, b.	Protein only RNase P catalytic subunit.	0.469
ENSPLAP00000003414	rpp14	ENSPLAP00000003414	ENSPLAP00000018195	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P/MRP 14 subunit.	0.994
ENSPLAP00000003414	rpp30	ENSPLAP00000003414	ENSPLAP00000020669	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P/MRP 30 subunit.	0.998
ENSPLAP00000003414	rpp38	ENSPLAP00000003414	ENSPLAP00000005688	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P/MRP 38 subunit.	0.999
ENSPLAP00000003414	rpp40	ENSPLAP00000003414	ENSPLAP00000019309	Ribonuclease P and MRP subunit p25, b.	Ribonuclease P/MRP 40 subunit.	0.997
ENSPLAP00000011922	ENSPLAP00000026969	ENSPLAP00000011922	ENSPLAP00000026969	ElaC ribonuclease Z 2.	Lactamase_B_4 domain-containing protein.	0.934
ENSPLAP00000011922	LOC106958625	ENSPLAP00000011922	ENSPLAP00000014915	ElaC ribonuclease Z 2.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.435
ENSPLAP00000011922	dicer1	ENSPLAP00000011922	ENSPLAP00000023302	ElaC ribonuclease Z 2.	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.426
ENSPLAP00000011922	drosha	ENSPLAP00000011922	ENSPLAP00000029456	ElaC ribonuclease Z 2.	Uncharacterized protein.	0.505
ENSPLAP00000011922	elac1	ENSPLAP00000011922	ENSPLAP00000000719	ElaC ribonuclease Z 2.	ElaC ribonuclease Z 1.	0.897
ENSPLAP00000011922	pop5	ENSPLAP00000011922	ENSPLAP00000026352	ElaC ribonuclease Z 2.	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.466
ENSPLAP00000011922	rnaseh2a	ENSPLAP00000011922	ENSPLAP00000012555	ElaC ribonuclease Z 2.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.435
ENSPLAP00000011922	rpp30	ENSPLAP00000011922	ENSPLAP00000020669	ElaC ribonuclease Z 2.	Ribonuclease P/MRP 30 subunit.	0.460
ENSPLAP00000024335	dicer1	ENSPLAP00000024335	ENSPLAP00000023302	Uncharacterized protein.	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.462
ENSPLAP00000024335	drosha	ENSPLAP00000024335	ENSPLAP00000029456	Uncharacterized protein.	Uncharacterized protein.	0.464