45 items (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	sppl3	Signal peptide peptidase 3. (382 aa)
	LOC106950609	RING-type domain-containing protein. (269 aa)
	LOC106950607	RING-type domain-containing protein. (285 aa)
	LOC106950610	RING-type domain-containing protein. (198 aa)
	LOC106955199	Spondin domain-containing protein. (593 aa)
	abl1	Tyrosine-protein kinase. (1117 aa)
	abl2	Tyrosine-protein kinase. (1186 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (255 aa)
	LOC106958271	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC106940222	Tribbles pseudokinase 3. (351 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (377 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (581 aa)
	spon1	Spondin 1a. (806 aa)
	LOC106937192	RING-type domain-containing protein. (412 aa)
	LOC106935614	Uncharacterized protein. (282 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (508 aa)
	LOC106950393	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (204 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2312 aa)
	LOC106950874	RING-type domain-containing protein. (205 aa)
	LOC106941608	Polycystic kidney disease 1a. (3231 aa)
	ENSPLAP00000013662	E1A binding protein p300 b. (2525 aa)
	ENSPLAP00000014644	zf-RING_14 domain-containing protein. (96 aa)
	ENSPLAP00000014649	RBR-type E3 ubiquitin transferase. (166 aa)
	vtn	Vitronectin a. (517 aa)
	LOC106946048	Tribbles homolog 2-like. (351 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	LOC106939157	Bone morphogenetic protein 16. (477 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	ENSPLAP00000028744	Ubiquitin-like domain-containing protein. (93 aa)
	men1	Multiple endocrine neoplasia I. (627 aa)
	LOC106946887	Apolipoprotein Ea. (251 aa)
	nvl	Nuclear VCP like. (815 aa)
	LOC106950872	Zgc:66440. (368 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (229 aa)
	LOC106938463	Apolipoprotein Eb. (265 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC106935131	Vitronectin b. (444 aa)
	LOC106939392	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1024 aa)
	LOC106937380	Rap guanine nucleotide exchange factor (GEF) 2. (1466 aa)
	LOC106950546	Rap guanine nucleotide exchange factor (GEF) 6. (1487 aa)
	ENSPLAP00000019292	RING-type domain-containing protein. (207 aa)
	ENSPLAP00000019276	RING-type domain-containing protein. (248 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000013662	LOC106939157	ENSPLAP00000013662	ENSPLAP00000029728	E1A binding protein p300 b.	Bone morphogenetic protein 16.	0.451
ENSPLAP00000013662	abl1	ENSPLAP00000013662	ENSPLAP00000003151	E1A binding protein p300 b.	Tyrosine-protein kinase.	0.491
ENSPLAP00000013662	abl2	ENSPLAP00000013662	ENSPLAP00000003434	E1A binding protein p300 b.	Tyrosine-protein kinase.	0.491
ENSPLAP00000013662	bmp4	ENSPLAP00000013662	ENSPLAP00000019124	E1A binding protein p300 b.	Bone morphogenetic protein 4.	0.451
ENSPLAP00000014644	abl1	ENSPLAP00000014644	ENSPLAP00000003151	zf-RING_14 domain-containing protein.	Tyrosine-protein kinase.	0.445
ENSPLAP00000014644	abl2	ENSPLAP00000014644	ENSPLAP00000003434	zf-RING_14 domain-containing protein.	Tyrosine-protein kinase.	0.445
ENSPLAP00000014644	cdk5	ENSPLAP00000014644	ENSPLAP00000027485	zf-RING_14 domain-containing protein.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.404
ENSPLAP00000014644	lrrk2	ENSPLAP00000014644	ENSPLAP00000012401	zf-RING_14 domain-containing protein.	Leucine-rich repeat kinase 2.	0.470
ENSPLAP00000014644	ripk2	ENSPLAP00000014644	ENSPLAP00000005915	zf-RING_14 domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.458
ENSPLAP00000014649	abl1	ENSPLAP00000014649	ENSPLAP00000003151	RBR-type E3 ubiquitin transferase.	Tyrosine-protein kinase.	0.445
ENSPLAP00000014649	abl2	ENSPLAP00000014649	ENSPLAP00000003434	RBR-type E3 ubiquitin transferase.	Tyrosine-protein kinase.	0.445
ENSPLAP00000014649	cdk5	ENSPLAP00000014649	ENSPLAP00000027485	RBR-type E3 ubiquitin transferase.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.404
ENSPLAP00000014649	lrrk2	ENSPLAP00000014649	ENSPLAP00000012401	RBR-type E3 ubiquitin transferase.	Leucine-rich repeat kinase 2.	0.470
ENSPLAP00000014649	ripk2	ENSPLAP00000014649	ENSPLAP00000005915	RBR-type E3 ubiquitin transferase.	Receptor-interacting serine-threonine kinase 2.	0.458
ENSPLAP00000019276	LOC106950607	ENSPLAP00000019276	ENSPLAP00000000439	RING-type domain-containing protein.	RING-type domain-containing protein.	0.530
ENSPLAP00000019292	LOC106950607	ENSPLAP00000019292	ENSPLAP00000000439	RING-type domain-containing protein.	RING-type domain-containing protein.	0.528
ENSPLAP00000028744	abl1	ENSPLAP00000028744	ENSPLAP00000003151	Ubiquitin-like domain-containing protein.	Tyrosine-protein kinase.	0.445
ENSPLAP00000028744	abl2	ENSPLAP00000028744	ENSPLAP00000003434	Ubiquitin-like domain-containing protein.	Tyrosine-protein kinase.	0.445
ENSPLAP00000028744	cdk5	ENSPLAP00000028744	ENSPLAP00000027485	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.404
ENSPLAP00000028744	lrrk2	ENSPLAP00000028744	ENSPLAP00000012401	Ubiquitin-like domain-containing protein.	Leucine-rich repeat kinase 2.	0.470