(105 nodes) Regulation of intracellular protein transport network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ube2g2	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	LOC106962473	ANK_REP_REGION domain-containing protein. (637 aa)
	MTCL1	Microtubule crosslinking factor 1. (1879 aa)
	hps4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (610 aa)
	uhmk1	U2AF homology motif (UHM) kinase 1. (437 aa)
	nup58	Nucleoporin 58. (594 aa)
	LOC106962366	Exportin 1 (CRM1 homolog, yeast) a. (1066 aa)
	ENSPLAP00000027389	annotation not available (161 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC106952069	Exportin 1 (CRM1 homolog, yeast) b. (1099 aa)
	ENSPLAP00000028929	BRCT domain-containing protein. (147 aa)
	sirt6	Sirtuin 6. (351 aa)
	sh3tc2	SH3 domain and tetratricopeptide repeats 2. (1416 aa)
	pcm1	Pericentriolar material 1. (2100 aa)
	gripap1	GRIP1 associated protein 1. (556 aa)
	rufy3	RUN and FYVE domain containing 3. (660 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (627 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	LOC106936767	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (324 aa)
	zfand1	Zinc finger, AN1-type domain 1. (269 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	LOC106963419	Uncharacterized protein. (288 aa)
	LOC106960064	Translocated promoter region b, nuclear basket protein. (1692 aa)
	tpr	Translocated promoter region a, nuclear basket protein. (2076 aa)
	oaz1	Ornithine decarboxylase antizyme 1a. (215 aa)
	ENSPLAP00000000224	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (155 aa)
	LOC106935927	Ran GTPase activating protein 1b. (564 aa)
	sirt7	Sirtuin 7. (410 aa)
	LOC106938150	Calcineurin-like EF-hand protein 2. (179 aa)
	pdcd5	Programmed cell death 5. (126 aa)
	RAB29	RAB29, member RAS oncogene family. (213 aa)
	TOMM7	Translocase of outer mitochondrial membrane 7. (51 aa)
	LOC106964789	Miff domain-containing protein. (287 aa)
	LOC106944503	Ornithine decarboxylase antizyme 1b. (212 aa)
	ENSPLAP00000003465	Uncharacterized protein. (514 aa)
	ENSPLAP00000003645	ZPR1 zinc finger. (429 aa)
	nf1	Neurofibromin 1b. (2795 aa)
	LOC106935707	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
	SLC35D3	Solute carrier family 35 member D3. (407 aa)
	tm9sf4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (645 aa)
	bag4	BCL2 associated athanogene 4. (378 aa)
	LOC106962609	Centrosomal protein 131. (1205 aa)
	svip	Si:ch73-147o17.1. (80 aa)
	gas6	Uncharacterized protein. (650 aa)
	LOC106963833	Junction plakoglobin a. (721 aa)
	mief2	Mitochondrial elongation factor 2. (465 aa)
	LOC106965160	Peptidase M60 domain-containing protein. (914 aa)
	bcas3	BCAS3 microtubule associated cell migration factor. (821 aa)
	LOC106939115	Ornithine decarboxylase antizyme 2a. (171 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (484 aa)
	LOC106965146	Peptidase M60 domain-containing protein. (905 aa)
	ube2j1	Ubiquitin-conjugating enzyme E2, J1. (318 aa)
	rab23	RAB23, member RAS oncogene family. (235 aa)
	c2cd5	C2 calcium dependent domain containing 5. (1043 aa)
	gcc2	GRIP domain-containing protein. (1646 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (189 aa)
	ctdspl2	CTD small phosphatase like 2. (476 aa)
	rapgef4	Zgc:171558. (977 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2312 aa)
	ENSPLAP00000012667	Uncharacterized protein. (161 aa)
	ENSPLAP00000012719	Uncharacterized protein. (161 aa)
	LOC106951552	Si:dkey-206d17.12. (404 aa)
	LOC106961620	Uncharacterized protein. (644 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	rangap1	RAN GTPase activating protein 1a. (560 aa)
	ENSPLAP00000014035	LEM domain-containing protein. (78 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	LOC106955687	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	tenm1	Teneurin transmembrane protein 1. (2695 aa)
	edem1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (638 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	ENSPLAP00000017116	Uncharacterized protein. (160 aa)
	LOC106936765	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa)
	LOC106958661	Uncharacterized protein. (256 aa)
	nkd1	NKD inhibitor of WNT signaling pathway 1. (434 aa)
	PTPN14	Protein tyrosine phosphatase non-receptor type 14. (814 aa)
	chp1	Calcineurin-like EF-hand protein 1. (195 aa)
	os9	OS9 endoplasmic reticulum lectin. (606 aa)
	edem2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (426 aa)
	LOC106944655	Secretion associated, Ras related GTPase 1Ab; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein. (376 aa)
	LOC106959971	PDZ domain containing 1. (518 aa)
	LOC106961276	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	LOC106941957	Epithelial cell transforming 2. (638 aa)
	LOC106952561	Nucleolar and coiled-body phosphoprotein 1. (1023 aa)
	LOC106947507	Transforming growth factor beta; Belongs to the TGF-beta family. (373 aa)
	ENSPLAP00000021328	Uncharacterized protein. (148 aa)
	erlec1	Endoplasmic reticulum lectin 1. (460 aa)
	LOC106955063	Rap guanine nucleotide exchange factor (GEF) 3. (799 aa)
	mief1	Mitochondrial elongation factor 1. (475 aa)
	bag3	BCL2 associated athanogene 3. (515 aa)
	LOC106962619	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3. (403 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2417 aa)
	LOC106935788	FCP1 homology domain-containing protein. (473 aa)
	LOC106947168	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	LOC106965118	Peptidase M60 domain-containing protein. (908 aa)
	LOC106965118-2	Peptidase M60 domain-containing protein. (849 aa)
	efcab7	EF-hand calcium binding domain 7. (612 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (316 aa)
	LOC106950964	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC106940938	Secretion associated, Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	b3gat3	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (337 aa)
	NUP54	Nucleoporin 54. (620 aa)
	pkig	Protein kinase (cAMP-dependent, catalytic) inhibitor gamma. (78 aa)
	ENSPLAP00000000066	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (136 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000000066	derl2	ENSPLAP00000000066	ENSPLAP00000014772	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.928
ENSPLAP00000000066	edem1	ENSPLAP00000000066	ENSPLAP00000016675	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.620
ENSPLAP00000000066	edem2	ENSPLAP00000000066	ENSPLAP00000018731	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.525
ENSPLAP00000000066	erlec1	ENSPLAP00000000066	ENSPLAP00000021676	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.962
ENSPLAP00000000066	os9	ENSPLAP00000000066	ENSPLAP00000018536	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.962
ENSPLAP00000000066	ube2g2	ENSPLAP00000000066	ENSPLAP00000017676	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.483
ENSPLAP00000000066	ube2j1	ENSPLAP00000000066	ENSPLAP00000008487	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2, J1.	0.610
ENSPLAP00000000224	LOC106940938	ENSPLAP00000000224	ENSPLAP00000025310	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	Secretion associated, Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family.	0.899
ENSPLAP00000000224	LOC106944655	ENSPLAP00000000224	ENSPLAP00000018912	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	Secretion associated, Ras related GTPase 1Ab; Belongs to the small GTPase superfamily. SAR1 family.	0.893
ENSPLAP00000003465	ENSPLAP00000012719	ENSPLAP00000003465	ENSPLAP00000012719	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSPLAP00000003465	ENSPLAP00000027389	ENSPLAP00000003465	ENSPLAP00000027389	Uncharacterized protein.	annotation not available	0.941
ENSPLAP00000003465	ENSPLAP00000028929	ENSPLAP00000003465	ENSPLAP00000028929	Uncharacterized protein.	BRCT domain-containing protein.	0.466
ENSPLAP00000003465	LOC106962473	ENSPLAP00000003465	ENSPLAP00000025950	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.466
ENSPLAP00000003465	LOC106962609	ENSPLAP00000003465	ENSPLAP00000006593	Uncharacterized protein.	Centrosomal protein 131.	0.554
ENSPLAP00000003465	pcm1	ENSPLAP00000003465	ENSPLAP00000029530	Uncharacterized protein.	Pericentriolar material 1.	0.756
ENSPLAP00000012719	ENSPLAP00000003465	ENSPLAP00000012719	ENSPLAP00000003465	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSPLAP00000012719	ENSPLAP00000028929	ENSPLAP00000012719	ENSPLAP00000028929	Uncharacterized protein.	BRCT domain-containing protein.	0.466
ENSPLAP00000012719	LOC106962473	ENSPLAP00000012719	ENSPLAP00000025950	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.466
ENSPLAP00000012719	LOC106962609	ENSPLAP00000012719	ENSPLAP00000006593	Uncharacterized protein.	Centrosomal protein 131.	0.554
ENSPLAP00000012719	pcm1	ENSPLAP00000012719	ENSPLAP00000029530	Uncharacterized protein.	Pericentriolar material 1.	0.734