(39 nodes) Cellular response to amino acid starvation network (Poecilia latipinna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	rragc	Ras-related GTP binding Ca. (382 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1184 aa)
	kptn	Kaptin (actin binding protein). (440 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (433 aa)
	dap	Death-associated protein. (105 aa)
	flcn	Folliculin. (554 aa)
	LOC106958432	Transcription factor EB. (330 aa)
	ENSPLAP00000009100	Uncharacterized protein. (274 aa)
	LOC106938764	Si:ch211-153j24.3. (382 aa)
	LOC106955731	Ras-related GTP binding A. (315 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	LOC106936789	Activating transcription factor 4a. (424 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (867 aa)
	LOC106942262	Ring finger protein 152. (174 aa)
	wdr24	WD repeat domain 24. (783 aa)
	impact	Impact RWD domain protein. (323 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (381 aa)
	LOC106945327	Uncharacterized protein. (639 aa)
	sesn1	Sestrin 1. (545 aa)
	LOC106940492	E3 ubiquitin-protein ligase RNF152-like. (174 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (595 aa)
	LOC106953096	Si:ch211-125a15.1. (452 aa)
	LOC106937241	Uncharacterized protein. (184 aa)
	LOC106949811	Si:zfos-80g12.1. (444 aa)
	ENSPLAP00000024381	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (214 aa)
	LOC106962851	Death associated protein 1b. (116 aa)
	LOC106947675	Uncharacterized protein. (363 aa)
	ENSPLAP00000028649	Uncharacterized protein. (166 aa)
	LOC106960824	Sestrin 2. (558 aa)
	ENSPLAP00000031455	Uncharacterized protein. (540 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	gcn1	GCN1 activator of EIF2AK4. (2634 aa)
	atf3	Activating transcription factor 3. (259 aa)
	ENSPLAP00000016894	CBM21 domain-containing protein. (292 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (387 aa)
	LOC106941359	Mechanistic target of rapamycin kinase. (927 aa)
	ENSPLAP00000016678	WD repeat domain 59. (701 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1104 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	ENSPLAP00000024381	ENSPLAP00000030376	ENSPLAP00000024381	Eukaryotic translation initiation factor 2 alpha kinase 4.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.709
EIF2AK4	ENSPLAP00000031455	ENSPLAP00000030376	ENSPLAP00000031455	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.709
EIF2AK4	LOC106936789	ENSPLAP00000030376	ENSPLAP00000002219	Eukaryotic translation initiation factor 2 alpha kinase 4.	Activating transcription factor 4a.	0.615
EIF2AK4	LOC106941359	ENSPLAP00000030376	ENSPLAP00000016783	Eukaryotic translation initiation factor 2 alpha kinase 4.	Mechanistic target of rapamycin kinase.	0.929
EIF2AK4	LOC106945327	ENSPLAP00000030376	ENSPLAP00000018431	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.709
EIF2AK4	LOC106955731	ENSPLAP00000030376	ENSPLAP00000004770	Eukaryotic translation initiation factor 2 alpha kinase 4.	Ras-related GTP binding A.	0.546
EIF2AK4	eif2ak3	ENSPLAP00000030376	ENSPLAP00000015768	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.942
EIF2AK4	eif2s1	ENSPLAP00000030376	ENSPLAP00000003800	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.996
EIF2AK4	gcn1	ENSPLAP00000030376	ENSPLAP00000030064	Eukaryotic translation initiation factor 2 alpha kinase 4.	GCN1 activator of EIF2AK4.	0.882
EIF2AK4	impact	ENSPLAP00000030376	ENSPLAP00000015088	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.554
EIF2AK4	lars1	ENSPLAP00000030376	ENSPLAP00000013047	Eukaryotic translation initiation factor 2 alpha kinase 4.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.692
ENSPLAP00000009100	ENSPLAP00000016678	ENSPLAP00000009100	ENSPLAP00000016678	Uncharacterized protein.	WD repeat domain 59.	0.804
ENSPLAP00000009100	ENSPLAP00000016894	ENSPLAP00000009100	ENSPLAP00000016894	Uncharacterized protein.	CBM21 domain-containing protein.	0.410
ENSPLAP00000009100	ENSPLAP00000028649	ENSPLAP00000009100	ENSPLAP00000028649	Uncharacterized protein.	Uncharacterized protein.	0.974
ENSPLAP00000009100	LOC106937241	ENSPLAP00000009100	ENSPLAP00000023586	Uncharacterized protein.	Uncharacterized protein.	0.621
ENSPLAP00000009100	LOC106941359	ENSPLAP00000009100	ENSPLAP00000016783	Uncharacterized protein.	Mechanistic target of rapamycin kinase.	0.995
ENSPLAP00000009100	LOC106949811	ENSPLAP00000009100	ENSPLAP00000023819	Uncharacterized protein.	Si:zfos-80g12.1.	0.607
ENSPLAP00000009100	LOC106953096	ENSPLAP00000009100	ENSPLAP00000021434	Uncharacterized protein.	Si:ch211-125a15.1.	0.641
ENSPLAP00000009100	LOC106955731	ENSPLAP00000009100	ENSPLAP00000004770	Uncharacterized protein.	Ras-related GTP binding A.	0.997
ENSPLAP00000009100	LOC106958432	ENSPLAP00000009100	ENSPLAP00000009139	Uncharacterized protein.	Transcription factor EB.	0.726