(26 nodes) Negative regulation of I-kappaB kinase/NF-kappaB signaling network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	otud7a	OTU deubiquitinase 7A. (956 aa)
	tank	TRAF family member-associated NFKB activator. (336 aa)
	LOC106948660	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (479 aa)
	ppm1b	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (386 aa)
	LOC106963250	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (437 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (506 aa)
	sirt1	Sirtuin 1. (677 aa)
	tnip1	TNFAIP3 interacting protein 1. (656 aa)
	otud7b	OTU deubiquitinase 7B. (912 aa)
	LOC106935033	Nuclear receptor subfamily 1, group d, member 1. (565 aa)
	LOC106947649	Nuclear receptor subfamily 1, group D, member 4a. (580 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (459 aa)
	LOC106951552	Si:dkey-206d17.12. (404 aa)
	nlrx1	NLR family member X1. (959 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (857 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (824 aa)
	LOC106961428	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (504 aa)
	ENSPLAP00000019050	Uncharacterized protein; Belongs to the peptidase C14A family. (347 aa)
	LOC106958504	Uncharacterized protein; Belongs to the peptidase C14A family. (474 aa)
	ENSPLAP00000019085	Uncharacterized protein; Belongs to the peptidase C14A family. (347 aa)
	zmynd11	Zinc finger, MYND-type containing 11. (665 aa)
	LOC106947837	Nuclear receptor subfamily 1, group H, member 5. (477 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC106954688	Ash1 (absent, small, or homeotic)-like (Drosophila). (2912 aa)
	LOC106938295	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa. (398 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (627 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	LOC106938295	ENSPLAP00000027807	ENSPLAP00000029373	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	0.447
CHUK	LOC106948660	ENSPLAP00000027807	ENSPLAP00000000623	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb.	0.447
CHUK	LOC106963250	ENSPLAP00000027807	ENSPLAP00000003159	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative).	0.447
CHUK	nlrx1	ENSPLAP00000027807	ENSPLAP00000013927	Component of inhibitor of nuclear factor kappa B kinase complex.	NLR family member X1.	0.696
CHUK	otud7a	ENSPLAP00000027807	ENSPLAP00000030174	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU deubiquitinase 7A.	0.519
CHUK	otud7b	ENSPLAP00000027807	ENSPLAP00000006943	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU deubiquitinase 7B.	0.519
CHUK	ppm1b	ENSPLAP00000027807	ENSPLAP00000002706	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba.	0.447
CHUK	tank	ENSPLAP00000027807	ENSPLAP00000000154	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NFKB activator.	0.695
CHUK	tnfaip3	ENSPLAP00000027807	ENSPLAP00000016818	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor, alpha-induced protein 3.	0.666
ENSPLAP00000019050	LOC106958504	ENSPLAP00000019050	ENSPLAP00000019053	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.894
LOC106938295	CHUK	ENSPLAP00000029373	ENSPLAP00000027807	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.447
LOC106938295	LOC106963250	ENSPLAP00000029373	ENSPLAP00000003159	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative).	0.955
LOC106947837	sirt1	ENSPLAP00000022273	ENSPLAP00000005614	Nuclear receptor subfamily 1, group H, member 5.	Sirtuin 1.	0.571
LOC106948660	CHUK	ENSPLAP00000000623	ENSPLAP00000027807	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.447
LOC106948660	ppm1b	ENSPLAP00000000623	ENSPLAP00000002706	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba.	0.954
LOC106951552	tank	ENSPLAP00000012851	ENSPLAP00000000154	Si:dkey-206d17.12.	TRAF family member-associated NFKB activator.	0.634
LOC106951552	tnfaip3	ENSPLAP00000012851	ENSPLAP00000016818	Si:dkey-206d17.12.	Tumor necrosis factor, alpha-induced protein 3.	0.442
LOC106954688	sirt1	ENSPLAP00000029233	ENSPLAP00000005614	Ash1 (absent, small, or homeotic)-like (Drosophila).	Sirtuin 1.	0.435
LOC106958504	ENSPLAP00000019050	ENSPLAP00000019053	ENSPLAP00000019050	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.894
LOC106958504	LOC106961428	ENSPLAP00000019053	ENSPLAP00000017359	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.907