(31 nodes) Negative regulation of protein secretion network (Poecilia latipinna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106943151	3-hydroxy-3-methylglutaryl coenzyme A reductase. (867 aa)
	LOC106935197	SSD domain-containing protein. (776 aa)
	drd3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (454 aa)
	LOC106963981	Kruppel-like factor 7b. (310 aa)
	ENSPLAP00000003958	Potassium inwardly-rectifying channel, subfamily J, member 11. (376 aa)
	LOC106955695	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (312 aa)
	sergef	Secretion regulating guanine nucleotide exchange factor. (421 aa)
	LOC106935070	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (318 aa)
	LOC106965123	Rhomboid 5 homolog 1b (Drosophila). (894 aa)
	klf7	Kruppel like factor 7. (293 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	ENSPLAP00000014644	zf-RING_14 domain-containing protein. (96 aa)
	ENSPLAP00000014649	RBR-type E3 ubiquitin transferase. (166 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (162 aa)
	drd4	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC106958393	Uncharacterized protein. (86 aa)
	LOC106942158	Rhomboid 5 homolog 1a (Drosophila). (862 aa)
	LOC106942092	3-hydroxy-3-methylglutaryl coenzyme A reductase. (849 aa)
	LOC106964065	Rhomboid 5 homolog 1a (Drosophila). (865 aa)
	midn	Ubiquitin-like domain-containing protein. (448 aa)
	LOC106952268	Zgc:171965; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	RHBDF2	Rhomboid 5 homolog 2. (826 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (418 aa)
	CCN3	Cellular communication network factor 3. (412 aa)
	LOC106954193	Midnolin. (542 aa)
	LOC106938463	Apolipoprotein Eb. (265 aa)
	LOC106946887	Apolipoprotein Ea. (251 aa)
	ENSPLAP00000028744	Ubiquitin-like domain-containing protein. (93 aa)
	LOC106952679	Uncharacterized protein. (158 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000003958	sergef	ENSPLAP00000003958	ENSPLAP00000006757	Potassium inwardly-rectifying channel, subfamily J, member 11.	Secretion regulating guanine nucleotide exchange factor.	0.602
ENSPLAP00000014644	pim3	ENSPLAP00000014644	ENSPLAP00000014385	zf-RING_14 domain-containing protein.	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	0.423
ENSPLAP00000014644	psmd9	ENSPLAP00000014644	ENSPLAP00000014969	zf-RING_14 domain-containing protein.	Proteasome 26S subunit, non-ATPase 9.	0.772
ENSPLAP00000014649	pim3	ENSPLAP00000014649	ENSPLAP00000014385	RBR-type E3 ubiquitin transferase.	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	0.423
ENSPLAP00000014649	psmd9	ENSPLAP00000014649	ENSPLAP00000014969	RBR-type E3 ubiquitin transferase.	Proteasome 26S subunit, non-ATPase 9.	0.772
ENSPLAP00000028744	pim3	ENSPLAP00000028744	ENSPLAP00000014385	Ubiquitin-like domain-containing protein.	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	0.423
ENSPLAP00000028744	psmd9	ENSPLAP00000028744	ENSPLAP00000014969	Ubiquitin-like domain-containing protein.	Proteasome 26S subunit, non-ATPase 9.	0.772
LOC106935070	LOC106952268	ENSPLAP00000007822	ENSPLAP00000025070	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	0.475
LOC106935070	drd3	ENSPLAP00000007822	ENSPLAP00000001412	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.723
LOC106935197	LOC106938463	ENSPLAP00000000481	ENSPLAP00000027342	SSD domain-containing protein.	Apolipoprotein Eb.	0.487
LOC106935197	LOC106942092	ENSPLAP00000000481	ENSPLAP00000019738	SSD domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.898
LOC106935197	LOC106943151	ENSPLAP00000000481	ENSPLAP00000031295	SSD domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.898
LOC106938463	LOC106935197	ENSPLAP00000027342	ENSPLAP00000000481	Apolipoprotein Eb.	SSD domain-containing protein.	0.487
LOC106942092	LOC106935197	ENSPLAP00000019738	ENSPLAP00000000481	3-hydroxy-3-methylglutaryl coenzyme A reductase.	SSD domain-containing protein.	0.898
LOC106943151	LOC106935197	ENSPLAP00000031295	ENSPLAP00000000481	3-hydroxy-3-methylglutaryl coenzyme A reductase.	SSD domain-containing protein.	0.898
LOC106952268	LOC106935070	ENSPLAP00000025070	ENSPLAP00000007822	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.475
LOC106952268	drd3	ENSPLAP00000025070	ENSPLAP00000001412	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.478
LOC106952268	drd4	ENSPLAP00000025070	ENSPLAP00000018352	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	0.475
drd3	LOC106935070	ENSPLAP00000001412	ENSPLAP00000007822	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.723
drd3	LOC106952268	ENSPLAP00000001412	ENSPLAP00000025070	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	0.478