22 items (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106937460	Mothers against decapentaplegic homolog. (510 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC106939157	Bone morphogenetic protein 16. (477 aa)
	ILK	Integrin linked kinase. (452 aa)
	wt1	WT1 transcription factor b. (422 aa)
	tcf21	Transcription factor 21. (175 aa)
	greb1	Growth regulating estrogen receptor binding 1. (1789 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	ENSPLAP00000018666	Transmembrane protein 59-like. (320 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
	GREM1	Gremlin. (182 aa)
	LOC106955382	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (141 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	ilk	Integrin linked kinase. (452 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (696 aa)
	LOC106961822	WT1 transcription factor a. (445 aa)
	LOC106939239	Mothers against decapentaplegic homolog. (534 aa)
	LOC106962694	Uncharacterized protein. (351 aa)
	hs2st1	Heparan sulfate 2-O-sulfotransferase 1a. (348 aa)
	LOC106944326	Mothers against decapentaplegic homolog. (503 aa)
	LOC106948519	Leucine zipper, putative tumor suppressor family member 3b. (655 aa)
	LOC106950541	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GREM1	LOC106939157	ENSPLAP00000016954	ENSPLAP00000029728	Gremlin.	Bone morphogenetic protein 16.	0.918
GREM1	bmp4	ENSPLAP00000016954	ENSPLAP00000019124	Gremlin.	Bone morphogenetic protein 4.	0.924
ILK	ilk	ENSPLAP00000024838	ENSPLAP00000011483	Integrin linked kinase.	Integrin linked kinase.	0.904
LOC106937460	LOC106939157	ENSPLAP00000019866	ENSPLAP00000029728	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.825
LOC106937460	LOC106939239	ENSPLAP00000019866	ENSPLAP00000006841	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.786
LOC106937460	LOC106944326	ENSPLAP00000019866	ENSPLAP00000003577	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.796
LOC106937460	bmp4	ENSPLAP00000019866	ENSPLAP00000019124	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.847
LOC106939157	GREM1	ENSPLAP00000029728	ENSPLAP00000016954	Bone morphogenetic protein 16.	Gremlin.	0.918
LOC106939157	LOC106937460	ENSPLAP00000029728	ENSPLAP00000019866	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.825
LOC106939157	LOC106939239	ENSPLAP00000029728	ENSPLAP00000006841	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.825
LOC106939157	LOC106944326	ENSPLAP00000029728	ENSPLAP00000003577	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.825
LOC106939157	bmp4	ENSPLAP00000029728	ENSPLAP00000019124	Bone morphogenetic protein 16.	Bone morphogenetic protein 4.	0.888
LOC106939239	LOC106937460	ENSPLAP00000006841	ENSPLAP00000019866	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.786
LOC106939239	LOC106939157	ENSPLAP00000006841	ENSPLAP00000029728	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.825
LOC106939239	LOC106944326	ENSPLAP00000006841	ENSPLAP00000003577	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.904
LOC106939239	bmp4	ENSPLAP00000006841	ENSPLAP00000019124	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.825
LOC106944326	LOC106937460	ENSPLAP00000003577	ENSPLAP00000019866	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.796
LOC106944326	LOC106939157	ENSPLAP00000003577	ENSPLAP00000029728	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.825
LOC106944326	LOC106939239	ENSPLAP00000003577	ENSPLAP00000006841	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.904
LOC106944326	bmp4	ENSPLAP00000003577	ENSPLAP00000019124	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.847