(106 nodes) Negative regulation of canonical Wnt signaling pathway network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC106945504	Uncharacterized protein. (964 aa)
	ENSPLAP00000014649	RBR-type E3 ubiquitin transferase. (166 aa)
	ENSPLAP00000014644	zf-RING_14 domain-containing protein. (96 aa)
	frzb	Frizzled related protein. (313 aa)
	ddit3	DNA-damage-inducible transcript 3. (313 aa)
	tmem170b	Transmembrane protein 170B. (154 aa)
	ENSPLAP00000014035	LEM domain-containing protein. (78 aa)
	nkx2-5	NK2 homeobox 5. (318 aa)
	tnn	Tenascin N. (1087 aa)
	dab2	DAB adaptor protein 2. (737 aa)
	LOC106935498	Uncharacterized protein. (227 aa)
	AXIN2	Axin 2. (794 aa)
	tmem64	Transmembrane protein 64. (350 aa)
	LOC106950393	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (204 aa)
	ENSPLAP00000010696	Gremlin 1a, DAN family BMP antagonist. (159 aa)
	sostdc1	Sclerostin domain containing 1a. (219 aa)
	notum	Notum, palmitoleoyl-protein carboxylesterase a. (352 aa)
	shisa3	Shisa family member 3. (278 aa)
	sox13	SRY-box transcription factor 13. (670 aa)
	dkk1	TNFR-Cys domain-containing protein. (251 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (696 aa)
	LOC106955551	APC membrane recruitment protein 1. (893 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (241 aa)
	ENSPLAP00000008549	APC_N_CC domain-containing protein. (276 aa)
	VANGL2	Vang-like protein. (485 aa)
	ANKRD6	Ankyrin repeat domain 6. (767 aa)
	dact3	Uncharacterized protein. (654 aa)
	bicc1	BicC family RNA binding protein 1a. (968 aa)
	LOC106949198	Uncharacterized protein. (275 aa)
	scyl2	SCY1 like pseudokinase 2. (913 aa)
	LOC106955679	Uncharacterized protein. (709 aa)
	LOC106937271	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
	lmbr1	Limb development membrane protein 1; Belongs to the LIMR family. (492 aa)
	LOC106949251	Transmembrane protein 88 a. (189 aa)
	LOC106949849	Mesoderm posterior ba. (249 aa)
	ubac2	UBA domain containing 2. (397 aa)
	LOC106959222	Uncharacterized protein. (883 aa)
	lats2	Large tumor suppressor kinase 2. (1140 aa)
	kremen1	Kringle containing transmembrane protein 1. (428 aa)
	znrf3	Zinc and ring finger 3. (814 aa)
	lmbr1l	Limb development membrane protein 1-like; Belongs to the LIMR family. (492 aa)
	LOC106947926	Dickkopf WNT signaling pathway inhibitor 3a. (295 aa)
	ENSPLAP00000002833	Dickkopf_N domain-containing protein. (256 aa)
	ENSPLAP00000002687	LRRCT domain-containing protein. (180 aa)
	LOC106963996	Insulin-like growth factor binding protein 6b. (201 aa)
	LOC106948519	Leucine zipper, putative tumor suppressor family member 3b. (655 aa)
	LOC106955269	Chico. (200 aa)
	LOC106951267	Uncharacterized protein. (512 aa)
	LOC106953938	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (512 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSPLAP00000030428	Nephronophthisis 4. (250 aa)
	LOC106937533	Uncharacterized protein. (754 aa)
	LOC106934671	LRRNT domain-containing protein. (191 aa)
	LOC106960831	Sizzled. (304 aa)
	ENSPLAP00000029337	Cylindromatosis (turban tumor syndrome), b. (583 aa)
	LOC106955430	Secreted frizzled-related protein 1a. (305 aa)
	LOC106939913	FZ domain-containing protein. (289 aa)
	chd8	Chromodomain helicase DNA binding protein 8. (2502 aa)
	ENSPLAP00000028744	Ubiquitin-like domain-containing protein. (93 aa)
	LOC106939840	R-spondin 3. (329 aa)
	LOC106946887	Apolipoprotein Ea. (251 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (229 aa)
	wnt11	Wnt family member 11. (357 aa)
	LOC106938463	Apolipoprotein Eb. (265 aa)
	amer2	APC membrane recruitment protein 2. (520 aa)
	LOC106957085	Axin 2 (conductin, axil). (838 aa)
	CSNK1A1	Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (364 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	LOC106964417	Secreted frizzled-related protein 5. (318 aa)
	LOC106963814	Bicaudal C homolog 2. (736 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
	LOC106959591	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (726 aa)
	LOC106953611	Uncharacterized protein. (367 aa)
	ENSPLAP00000023456	LRRCT domain-containing protein. (322 aa)
	LOC106937270	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LOC106954423	Prefoldin 5. (155 aa)
	LOC106941766	HMG box domain-containing protein. (238 aa)
	LOC106947788	TLE family member 5, transcriptional modulator. (203 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3b. (259 aa)
	LOC106943011	Notum pectinacetylesterase 2. (494 aa)
	LOC106947871	TLE family member 2, transcriptional corepressor a. (770 aa)
	LOC106947872	TLE family member 2, transcriptional corepressor b. (781 aa)
	ENSPLAP00000021328	Uncharacterized protein. (148 aa)
	nphp4	Uncharacterized protein. (877 aa)
	lats1	Large tumor suppressor kinase 1. (1042 aa)
	LOC106957188	Vang-like protein. (525 aa)
	tle1	Uncharacterized protein. (784 aa)
	ENSPLAP00000019546	TLE_N domain-containing protein. (91 aa)
	LOC106961276	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	LOC106937680	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (767 aa)
	cby1	Chibby homolog 1 (Drosophila). (133 aa)
	ENSPLAP00000018916	Trophoblast glycoprotein-like. (376 aa)
	nkd1	NKD inhibitor of WNT signaling pathway 1. (434 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (908 aa)
	frmd8	FERM domain containing 8. (467 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2049 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (744 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	GREM1	Gremlin. (182 aa)
	ENSPLAP00000016571	Trophoblast glycoprotein a. (198 aa)
	axin1	Axin 1. (795 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	LOC106955687	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	ENSPLAP00000015317	NKD inhibitor of WNT signaling pathway 2a. (357 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD6	AXIN2	ENSPLAP00000008228	ENSPLAP00000012430	Ankyrin repeat domain 6.	Axin 2.	0.492
ANKRD6	ENSPLAP00000021328	ENSPLAP00000008228	ENSPLAP00000021328	Ankyrin repeat domain 6.	Uncharacterized protein.	0.404
ANKRD6	ENSPLAP00000029337	ENSPLAP00000008228	ENSPLAP00000029337	Ankyrin repeat domain 6.	Cylindromatosis (turban tumor syndrome), b.	0.547
ANKRD6	LOC106937680	ENSPLAP00000008228	ENSPLAP00000019505	Ankyrin repeat domain 6.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.547
ANKRD6	LOC106945504	ENSPLAP00000008228	ENSPLAP00000014956	Ankyrin repeat domain 6.	Uncharacterized protein.	0.547
ANKRD6	LOC106955687	ENSPLAP00000008228	ENSPLAP00000015473	Ankyrin repeat domain 6.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.404
ANKRD6	LOC106957085	ENSPLAP00000008228	ENSPLAP00000026802	Ankyrin repeat domain 6.	Axin 2 (conductin, axil).	0.492
ANKRD6	LOC106957188	ENSPLAP00000008228	ENSPLAP00000019954	Ankyrin repeat domain 6.	Vang-like protein.	0.584
ANKRD6	LOC106959222	ENSPLAP00000008228	ENSPLAP00000004707	Ankyrin repeat domain 6.	Uncharacterized protein.	0.492
ANKRD6	LOC106961276	ENSPLAP00000008228	ENSPLAP00000019535	Ankyrin repeat domain 6.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.404
ANKRD6	VANGL2	ENSPLAP00000008228	ENSPLAP00000008392	Ankyrin repeat domain 6.	Vang-like protein.	0.584
ANKRD6	axin1	ENSPLAP00000008228	ENSPLAP00000016337	Ankyrin repeat domain 6.	Axin 1.	0.492
ANKRD6	cyld	ENSPLAP00000008228	ENSPLAP00000018016	Ankyrin repeat domain 6.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.547
ANKRD6	gsk3b	ENSPLAP00000008228	ENSPLAP00000016984	Ankyrin repeat domain 6.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.404
AXIN2	ANKRD6	ENSPLAP00000012430	ENSPLAP00000008228	Axin 2.	Ankyrin repeat domain 6.	0.492
AXIN2	CSNK1A1	ENSPLAP00000012430	ENSPLAP00000026450	Axin 2.	Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily.	0.975
AXIN2	ENSPLAP00000008549	ENSPLAP00000012430	ENSPLAP00000008549	Axin 2.	APC_N_CC domain-containing protein.	0.912
AXIN2	ENSPLAP00000021328	ENSPLAP00000012430	ENSPLAP00000021328	Axin 2.	Uncharacterized protein.	0.859
AXIN2	LOC106937270	ENSPLAP00000012430	ENSPLAP00000023282	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.646
AXIN2	LOC106937271	ENSPLAP00000012430	ENSPLAP00000006365	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.646