(12 nodes) Ubiquitin-activating enzyme network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	uba1	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1057 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (646 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (728 aa)
	LOC106949458	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
	LOC106962111	Molybdenum cofactor synthesis 3. (384 aa)
	uba6	Ubiquitin like modifier activating enzyme 6. (1042 aa)
	LOC106953339	Ubiquitin-like modifier activating enzyme 3. (442 aa)
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	sae1	SUMO1 activating enzyme subunit 1. (345 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (400 aa)
	mocs3	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (450 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106949458	LOC106953339	ENSPLAP00000016551	ENSPLAP00000018344	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 3.	0.775
LOC106949458	UBA3	ENSPLAP00000016551	ENSPLAP00000006977	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 3.	0.775
LOC106949458	atg7	ENSPLAP00000016551	ENSPLAP00000015300	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.793
LOC106949458	nae1	ENSPLAP00000016551	ENSPLAP00000006411	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.422
LOC106949458	uba1	ENSPLAP00000016551	ENSPLAP00000010960	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.924
LOC106949458	uba2	ENSPLAP00000016551	ENSPLAP00000012391	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.410
LOC106949458	uba5	ENSPLAP00000016551	ENSPLAP00000022195	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 5.	0.773
LOC106949458	uba6	ENSPLAP00000016551	ENSPLAP00000018201	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 6.	0.925
LOC106953339	LOC106949458	ENSPLAP00000018344	ENSPLAP00000016551	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.775
LOC106953339	LOC106962111	ENSPLAP00000018344	ENSPLAP00000017145	Ubiquitin-like modifier activating enzyme 3.	Molybdenum cofactor synthesis 3.	0.405
LOC106953339	UBA3	ENSPLAP00000018344	ENSPLAP00000006977	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 3.	0.923
LOC106953339	atg7	ENSPLAP00000018344	ENSPLAP00000015300	Ubiquitin-like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.802
LOC106953339	mocs3	ENSPLAP00000018344	ENSPLAP00000028804	Ubiquitin-like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.405
LOC106953339	nae1	ENSPLAP00000018344	ENSPLAP00000006411	Ubiquitin-like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.995
LOC106953339	sae1	ENSPLAP00000018344	ENSPLAP00000019988	Ubiquitin-like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.481
LOC106953339	uba1	ENSPLAP00000018344	ENSPLAP00000010960	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.775
LOC106953339	uba5	ENSPLAP00000018344	ENSPLAP00000022195	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.786
LOC106953339	uba6	ENSPLAP00000018344	ENSPLAP00000018201	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 6.	0.775
LOC106962111	LOC106953339	ENSPLAP00000017145	ENSPLAP00000018344	Molybdenum cofactor synthesis 3.	Ubiquitin-like modifier activating enzyme 3.	0.405
LOC106962111	UBA3	ENSPLAP00000017145	ENSPLAP00000006977	Molybdenum cofactor synthesis 3.	Ubiquitin like modifier activating enzyme 3.	0.405