42 items (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106947673	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (479 aa)
	rnf128	RING-type domain-containing protein. (362 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (703 aa)
	ENSPLAP00000001591	Zgc:136908; Belongs to the AAA ATPase family. (479 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (249 aa)
	cskmt	Methyltranfer_dom domain-containing protein. (254 aa)
	otub1	Ubiquitin thioesterase. (266 aa)
	LOC106956601	KxDL motif containing 1. (185 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (412 aa)
	otud3	OTU deubiquitinase 3. (358 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (581 aa)
	tnip1	TNFAIP3 interacting protein 1. (656 aa)
	otud7b	OTU deubiquitinase 7B. (912 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (748 aa)
	LOC106951701	OTU domain-containing protein. (226 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	ENSPLAP00000008549	APC_N_CC domain-containing protein. (276 aa)
	LOC106962387	Zinc finger, RAN-binding domain containing 1b. (775 aa)
	SPATA5	Spermatogenesis associated 5. (904 aa)
	LOC106938509	kxDL motif-containing protein 1-like. (185 aa)
	LOC106936332	YOD1 deubiquitinase. (300 aa)
	ENSPLAP00000015559	Ubiquitin-like domain-containing protein. (93 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (824 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2049 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (623 aa)
	otud4	OTU domain-containing protein. (1259 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC106956608	Motor neuron and pancreas homeobox 2a. (342 aa)
	LOC106955102	Uncharacterized protein. (708 aa)
	vcpip1	Valosin containing protein (p97)/p47 complex interacting protein 1. (1172 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
	LOC106940083	Ubiquitin thioesterase OTU1. (300 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (941 aa)
	rnf13	Ring finger protein 13. (378 aa)
	otud7a	OTU deubiquitinase 7A. (956 aa)
	LOC106953365	Ring finger protein 167. (397 aa)
	guf1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (668 aa)
	otud5	OTU deubiquitinase 5a. (302 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000001591	ENSPLAP00000015559	ENSPLAP00000001591	ENSPLAP00000015559	Zgc:136908; Belongs to the AAA ATPase family.	Ubiquitin-like domain-containing protein.	0.832
ENSPLAP00000001591	LOC106936332	ENSPLAP00000001591	ENSPLAP00000012167	Zgc:136908; Belongs to the AAA ATPase family.	YOD1 deubiquitinase.	0.911
ENSPLAP00000001591	LOC106940083	ENSPLAP00000001591	ENSPLAP00000023919	Zgc:136908; Belongs to the AAA ATPase family.	Ubiquitin thioesterase OTU1.	0.911
ENSPLAP00000001591	LOC106955102	ENSPLAP00000001591	ENSPLAP00000021890	Zgc:136908; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.469
ENSPLAP00000001591	LOC106962387	ENSPLAP00000001591	ENSPLAP00000011752	Zgc:136908; Belongs to the AAA ATPase family.	Zinc finger, RAN-binding domain containing 1b.	0.469
ENSPLAP00000001591	otud7a	ENSPLAP00000001591	ENSPLAP00000030174	Zgc:136908; Belongs to the AAA ATPase family.	OTU deubiquitinase 7A.	0.469
ENSPLAP00000001591	otud7b	ENSPLAP00000001591	ENSPLAP00000006943	Zgc:136908; Belongs to the AAA ATPase family.	OTU deubiquitinase 7B.	0.469
ENSPLAP00000001591	ripk1	ENSPLAP00000001591	ENSPLAP00000001098	Zgc:136908; Belongs to the AAA ATPase family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.435
ENSPLAP00000001591	ripk2	ENSPLAP00000001591	ENSPLAP00000005915	Zgc:136908; Belongs to the AAA ATPase family.	Receptor-interacting serine-threonine kinase 2.	0.435
ENSPLAP00000001591	rps27a	ENSPLAP00000001591	ENSPLAP00000025723	Zgc:136908; Belongs to the AAA ATPase family.	Ribosomal protein S27a.	0.881
ENSPLAP00000001591	tnfaip3	ENSPLAP00000001591	ENSPLAP00000016818	Zgc:136908; Belongs to the AAA ATPase family.	Tumor necrosis factor, alpha-induced protein 3.	0.469
ENSPLAP00000001591	tp53	ENSPLAP00000001591	ENSPLAP00000022694	Zgc:136908; Belongs to the AAA ATPase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.400
ENSPLAP00000001591	uba52	ENSPLAP00000001591	ENSPLAP00000027495	Zgc:136908; Belongs to the AAA ATPase family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.847
ENSPLAP00000001591	vcp	ENSPLAP00000001591	ENSPLAP00000020295	Zgc:136908; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.954
ENSPLAP00000001591	vcpip1	ENSPLAP00000001591	ENSPLAP00000022683	Zgc:136908; Belongs to the AAA ATPase family.	Valosin containing protein (p97)/p47 complex interacting protein 1.	0.958
ENSPLAP00000008549	LOC106955102	ENSPLAP00000008549	ENSPLAP00000021890	APC_N_CC domain-containing protein.	Uncharacterized protein.	0.719
ENSPLAP00000008549	LOC106962387	ENSPLAP00000008549	ENSPLAP00000011752	APC_N_CC domain-containing protein.	Zinc finger, RAN-binding domain containing 1b.	0.719
ENSPLAP00000008549	otud7a	ENSPLAP00000008549	ENSPLAP00000030174	APC_N_CC domain-containing protein.	OTU deubiquitinase 7A.	0.670
ENSPLAP00000008549	otud7b	ENSPLAP00000008549	ENSPLAP00000006943	APC_N_CC domain-containing protein.	OTU deubiquitinase 7B.	0.670
ENSPLAP00000008549	ripk1	ENSPLAP00000008549	ENSPLAP00000001098	APC_N_CC domain-containing protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.451