(9 nodes) ThiF family network (Poecilia latipinna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Your Input:
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (646 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (728 aa)
	LOC106962111	Molybdenum cofactor synthesis 3. (384 aa)
	LOC106953339	Ubiquitin-like modifier activating enzyme 3. (442 aa)
	sae1	SUMO1 activating enzyme subunit 1. (345 aa)
	mocs3	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (450 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (400 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106953339	LOC106962111	ENSPLAP00000018344	ENSPLAP00000017145	Ubiquitin-like modifier activating enzyme 3.	Molybdenum cofactor synthesis 3.	0.405
LOC106953339	UBA3	ENSPLAP00000018344	ENSPLAP00000006977	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 3.	0.923
LOC106953339	atg7	ENSPLAP00000018344	ENSPLAP00000015300	Ubiquitin-like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.802
LOC106953339	mocs3	ENSPLAP00000018344	ENSPLAP00000028804	Ubiquitin-like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.405
LOC106953339	nae1	ENSPLAP00000018344	ENSPLAP00000006411	Ubiquitin-like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.995
LOC106953339	sae1	ENSPLAP00000018344	ENSPLAP00000019988	Ubiquitin-like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.481
LOC106953339	uba5	ENSPLAP00000018344	ENSPLAP00000022195	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.786
LOC106962111	LOC106953339	ENSPLAP00000017145	ENSPLAP00000018344	Molybdenum cofactor synthesis 3.	Ubiquitin-like modifier activating enzyme 3.	0.405
LOC106962111	UBA3	ENSPLAP00000017145	ENSPLAP00000006977	Molybdenum cofactor synthesis 3.	Ubiquitin like modifier activating enzyme 3.	0.405
LOC106962111	atg7	ENSPLAP00000017145	ENSPLAP00000015300	Molybdenum cofactor synthesis 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.461
LOC106962111	nae1	ENSPLAP00000017145	ENSPLAP00000006411	Molybdenum cofactor synthesis 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.410
UBA3	LOC106953339	ENSPLAP00000006977	ENSPLAP00000018344	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 3.	0.923
UBA3	LOC106962111	ENSPLAP00000006977	ENSPLAP00000017145	Ubiquitin like modifier activating enzyme 3.	Molybdenum cofactor synthesis 3.	0.405
UBA3	atg7	ENSPLAP00000006977	ENSPLAP00000015300	Ubiquitin like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.802
UBA3	mocs3	ENSPLAP00000006977	ENSPLAP00000028804	Ubiquitin like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.405
UBA3	nae1	ENSPLAP00000006977	ENSPLAP00000006411	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.995
UBA3	sae1	ENSPLAP00000006977	ENSPLAP00000019988	Ubiquitin like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.481
UBA3	uba5	ENSPLAP00000006977	ENSPLAP00000022195	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.786
atg7	LOC106953339	ENSPLAP00000015300	ENSPLAP00000018344	ATG7 autophagy related 7 homolog (S. cerevisiae).	Ubiquitin-like modifier activating enzyme 3.	0.802
atg7	LOC106962111	ENSPLAP00000015300	ENSPLAP00000017145	ATG7 autophagy related 7 homolog (S. cerevisiae).	Molybdenum cofactor synthesis 3.	0.461