STRINGSTRING
rfc3 rfc3 pole3 pole3 ENSPMEP00000000796 ENSPMEP00000000796 orc2 orc2 gins4 gins4 LOC106909894 LOC106909894 pola2 pola2 LOC106929990 LOC106929990 cdc45 cdc45 mcm7 mcm7 gmnn gmnn mcmbp mcmbp mcm2 mcm2 pcna pcna dna2 dna2 tipin tipin gen1 gen1 ENSPMEP00000007297 ENSPMEP00000007297 pola1 pola1 LOC106911194 LOC106911194 gins3 gins3 dbf4 dbf4 LOC106928751 LOC106928751 cdt1 cdt1 atad5 atad5 rfc2 rfc2 fen1 fen1 lig1 lig1 chtf8 chtf8 mcm9 mcm9 LOC106909509 LOC106909509 rfc5 rfc5 orc3 orc3 prim1 prim1 pole4 pole4 orc4 orc4 wdhd1 wdhd1 LOC106907852 LOC106907852 prim2 prim2 mcm10 mcm10 orc5 orc5 pold1 pold1 cdc7 cdc7 LOC106934012 LOC106934012 orc1 orc1 pold3 pold3 rfc4 rfc4 dscc1 dscc1 LOC106927661 LOC106927661 LOC106912372 LOC106912372 gins2 gins2 rfc1 rfc1 pole2 pole2 mcm6 mcm6 timeless timeless MCMDC2 MCMDC2 LOC106929849 LOC106929849 cdc6 cdc6 ENSPMEP00000032240 ENSPMEP00000032240 POLE POLE mcm3 mcm3 pold2 pold2 mcm4 mcm4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc3Replication factor C (activator 1) 3. (376 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
ENSPMEP00000000796RAD17 checkpoint clamp loader component. (531 aa)
orc2Origin recognition complex, subunit 2. (580 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (225 aa)
LOC106909894DBF4-type domain-containing protein. (698 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (606 aa)
LOC106929990Zgc:110269. (351 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (571 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
gmnnGeminin DNA replication inhibitor. (216 aa)
mcmbpMinichromosome maintenance complex binding protein. (630 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (282 aa)
dna2Uncharacterized protein. (1356 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa)
gen1Chromo_2 domain-containing protein. (642 aa)
ENSPMEP00000007297Uncharacterized protein. (216 aa)
pola1DNA polymerase. (1478 aa)
LOC106911194WD_REPEATS_REGION domain-containing protein. (263 aa)
gins3GINS complex subunit 3. (211 aa)
dbf4DBF4 zinc finger. (597 aa)
LOC106928751DNA helicase; Belongs to the MCM family. (683 aa)
cdt1Chromatin licensing and DNA replication factor 1. (650 aa)
atad5AAA domain-containing protein. (825 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
lig1DNA ligase. (1002 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (137 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (951 aa)
LOC106909509GINS complex subunit 1 (Psf1 homolog). (196 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
orc3Origin recognition complex, subunit 3. (723 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (437 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (1040 aa)
LOC106907852Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (882 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (871 aa)
orc5Origin recognition complex, subunit 5. (442 aa)
pold1DNA polymerase. (1105 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (609 aa)
LOC106934012ATPase family AAA domain containing 5a. (1813 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (913 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
LOC106927661DNA helicase; Belongs to the MCM family. (737 aa)
LOC106912372DNA replication complex GINS protein PSF1. (196 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
rfc1Replication factor C subunit 1. (1167 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
mcm6DNA helicase; Belongs to the MCM family. (572 aa)
timelessTimeless circadian clock. (1250 aa)
MCMDC2Minichromosome maintenance domain containing 2. (669 aa)
LOC106929849SCY domain-containing protein. (125 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (637 aa)
ENSPMEP00000032240DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (364 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1123 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (468 aa)
mcm4DNA helicase; Belongs to the MCM family. (868 aa)
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
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