(19 nodes) Coated pit, and Beta-adaptin appendage, C-terminal subdomain network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPMEP00000003094	B2-adapt-app_C domain-containing protein. (137 aa)
	LOC106925764	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (926 aa)
	LOC106915100	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1614 aa)
	itsn2	Intersectin 2a. (1540 aa)
	ENSPMEP00000009513	SH3 domain-containing protein. (67 aa)
	gak	Cyclin G associated kinase. (1308 aa)
	ENSPMEP00000015051	B2-adapt-app_C domain-containing protein. (202 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (454 aa)
	LOC106926606	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1655 aa)
	LOC106905474	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (220 aa)
	LOC106908947	AP complex subunit beta. (876 aa)
	LOC106921732	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1370 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (199 aa)
	ENSPMEP00000027183	Uncharacterized protein. (282 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	LOC106932583	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (496 aa)
	LOC106909235	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (930 aa)
	ap4e1	AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family. (1127 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000003094	ENSPMEP00000009513	ENSPMEP00000003094	ENSPMEP00000009513	B2-adapt-app_C domain-containing protein.	SH3 domain-containing protein.	0.999
ENSPMEP00000003094	ENSPMEP00000027183	ENSPMEP00000003094	ENSPMEP00000027183	B2-adapt-app_C domain-containing protein.	Uncharacterized protein.	0.999
ENSPMEP00000003094	LOC106905474	ENSPMEP00000003094	ENSPMEP00000019519	B2-adapt-app_C domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.882
ENSPMEP00000003094	LOC106908947	ENSPMEP00000003094	ENSPMEP00000022165	B2-adapt-app_C domain-containing protein.	AP complex subunit beta.	0.907
ENSPMEP00000003094	LOC106909235	ENSPMEP00000003094	ENSPMEP00000032496	B2-adapt-app_C domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.962
ENSPMEP00000003094	LOC106915100	ENSPMEP00000003094	ENSPMEP00000004721	B2-adapt-app_C domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.876
ENSPMEP00000003094	LOC106921732	ENSPMEP00000003094	ENSPMEP00000022592	B2-adapt-app_C domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.876
ENSPMEP00000003094	LOC106925764	ENSPMEP00000003094	ENSPMEP00000004448	B2-adapt-app_C domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.955
ENSPMEP00000003094	LOC106926606	ENSPMEP00000003094	ENSPMEP00000017778	B2-adapt-app_C domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.876
ENSPMEP00000003094	LOC106932583	ENSPMEP00000003094	ENSPMEP00000031140	B2-adapt-app_C domain-containing protein.	AP complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.691
ENSPMEP00000003094	ap2m1	ENSPMEP00000003094	ENSPMEP00000015330	B2-adapt-app_C domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.971
ENSPMEP00000003094	ap2s1	ENSPMEP00000003094	ENSPMEP00000028648	B2-adapt-app_C domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.964
ENSPMEP00000003094	ap4e1	ENSPMEP00000003094	ENSPMEP00000034509	B2-adapt-app_C domain-containing protein.	AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family.	0.923
ENSPMEP00000003094	cltb	ENSPMEP00000003094	ENSPMEP00000025167	B2-adapt-app_C domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.882
ENSPMEP00000003094	cltc	ENSPMEP00000003094	ENSPMEP00000028269	B2-adapt-app_C domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.876
ENSPMEP00000003094	gak	ENSPMEP00000003094	ENSPMEP00000013903	B2-adapt-app_C domain-containing protein.	Cyclin G associated kinase.	0.997
ENSPMEP00000003094	itsn2	ENSPMEP00000003094	ENSPMEP00000009069	B2-adapt-app_C domain-containing protein.	Intersectin 2a.	0.999
ENSPMEP00000009513	ENSPMEP00000003094	ENSPMEP00000009513	ENSPMEP00000003094	SH3 domain-containing protein.	B2-adapt-app_C domain-containing protein.	0.999
ENSPMEP00000009513	ENSPMEP00000015051	ENSPMEP00000009513	ENSPMEP00000015051	SH3 domain-containing protein.	B2-adapt-app_C domain-containing protein.	0.999
ENSPMEP00000009513	ENSPMEP00000027183	ENSPMEP00000009513	ENSPMEP00000027183	SH3 domain-containing protein.	Uncharacterized protein.	0.993