(39 nodes) Mixed, incl. MTOR signalling, and FOXO protein, KIX-binding domain network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106904726	Uncharacterized protein. (155 aa)
	ENSPMEP00000000772	Raptor_N domain-containing protein. (85 aa)
	tbc1d7	TBC1 domain family, member 7. (294 aa)
	LOC106933666	Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (199 aa)
	LOC106933633	Non-specific serine/threonine protein kinase. (508 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	sgk2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (361 aa)
	LOC106909743	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (475 aa)
	LOC106927524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ENSPMEP00000006664	DEP domain-containing protein. (102 aa)
	LOC106915730	Fork-head domain-containing protein. (640 aa)
	deptor	DEP domain containing MTOR-interacting protein. (266 aa)
	LOC106919496	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
	LOC106928689	Ribosomal protein S6 kinase b, polypeptide 1b. (140 aa)
	LOC106907095	Fork-head domain-containing protein. (607 aa)
	LOC106929945	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (298 aa)
	SGK1	Non-specific serine/threonine protein kinase. (625 aa)
	LOC106906339	TSC complex subunit 1b. (1250 aa)
	LOC106905589	Si:dkeyp-97e7.9. (282 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1572 aa)
	LOC106929190	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
	rhebl1	Ras homolog, mTORC1 binding like 1. (184 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1294 aa)
	akt1s1	AKT1 substrate 1 (proline-rich). (351 aa)
	tsc1	Uncharacterized protein. (161 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	crygn	Crystallin, gamma N2; Belongs to the beta/gamma-crystallin family. (183 aa)
	sirt1	Sirtuin 1. (677 aa)
	LOC106932106	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	foxo3	Forkhead box O3b. (664 aa)
	LOC106914462	Forkhead box O1 a. (681 aa)
	mapkap1	MAPK associated protein 1. (538 aa)
	LOC106911072	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
	LOC106928688	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (468 aa)
	sgk3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	tsc2	TSC complex subunit 2. (1698 aa)
	rheb	Ras homolog, mTORC1 binding. (183 aa)
	LOC106911720	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1-like. (565 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000000772	ENSPMEP00000006664	ENSPMEP00000000772	ENSPMEP00000006664	Raptor_N domain-containing protein.	DEP domain-containing protein.	0.951
ENSPMEP00000000772	LOC106904726	ENSPMEP00000000772	ENSPMEP00000000409	Raptor_N domain-containing protein.	Uncharacterized protein.	0.931
ENSPMEP00000000772	LOC106905589	ENSPMEP00000000772	ENSPMEP00000016399	Raptor_N domain-containing protein.	Si:dkeyp-97e7.9.	0.941
ENSPMEP00000000772	LOC106906339	ENSPMEP00000000772	ENSPMEP00000016367	Raptor_N domain-containing protein.	TSC complex subunit 1b.	0.738
ENSPMEP00000000772	LOC106909743	ENSPMEP00000000772	ENSPMEP00000005503	Raptor_N domain-containing protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.962
ENSPMEP00000000772	LOC106911072	ENSPMEP00000000772	ENSPMEP00000027522	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.789
ENSPMEP00000000772	LOC106919496	ENSPMEP00000000772	ENSPMEP00000011084	Raptor_N domain-containing protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.962
ENSPMEP00000000772	LOC106927524	ENSPMEP00000000772	ENSPMEP00000006139	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.719
ENSPMEP00000000772	LOC106928688	ENSPMEP00000000772	ENSPMEP00000028254	Raptor_N domain-containing protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.944
ENSPMEP00000000772	LOC106928689	ENSPMEP00000000772	ENSPMEP00000011164	Raptor_N domain-containing protein.	Ribosomal protein S6 kinase b, polypeptide 1b.	0.944
ENSPMEP00000000772	LOC106929190	ENSPMEP00000000772	ENSPMEP00000017269	Raptor_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.786
ENSPMEP00000000772	LOC106929945	ENSPMEP00000000772	ENSPMEP00000013254	Raptor_N domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.969
ENSPMEP00000000772	LOC106932106	ENSPMEP00000000772	ENSPMEP00000025411	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.719
ENSPMEP00000000772	LOC106933633	ENSPMEP00000000772	ENSPMEP00000002682	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase.	0.719
ENSPMEP00000000772	LOC106933666	ENSPMEP00000000772	ENSPMEP00000002098	Raptor_N domain-containing protein.	Uncharacterized protein; Belongs to the beta/gamma-crystallin family.	0.799
ENSPMEP00000000772	SGK1	ENSPMEP00000000772	ENSPMEP00000013280	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase.	0.789
ENSPMEP00000000772	akt1	ENSPMEP00000000772	ENSPMEP00000004345	Raptor_N domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.719
ENSPMEP00000000772	akt1s1	ENSPMEP00000000772	ENSPMEP00000020540	Raptor_N domain-containing protein.	AKT1 substrate 1 (proline-rich).	0.994
ENSPMEP00000000772	crygn	ENSPMEP00000000772	ENSPMEP00000023677	Raptor_N domain-containing protein.	Crystallin, gamma N2; Belongs to the beta/gamma-crystallin family.	0.799
ENSPMEP00000000772	deptor	ENSPMEP00000000772	ENSPMEP00000008825	Raptor_N domain-containing protein.	DEP domain containing MTOR-interacting protein.	0.951