(12 nodes) Mixed, incl. AKT-mediated inactivation of FOXO1A, and 3-phosphoinositide-dependent protein kinase activity network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106933633	Non-specific serine/threonine protein kinase. (508 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	sgk2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (361 aa)
	LOC106927524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC106915730	Fork-head domain-containing protein. (640 aa)
	SGK1	Non-specific serine/threonine protein kinase. (625 aa)
	LOC106929190	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
	LOC106914462	Forkhead box O1 a. (681 aa)
	LOC106911072	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
	sgk3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	LOC106911720	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1-like. (565 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106911072	LOC106911720	ENSPMEP00000027522	ENSPMEP00000032988	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1b.	0.961
LOC106911072	LOC106914462	ENSPMEP00000027522	ENSPMEP00000025901	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1 a.	0.939
LOC106911072	LOC106915730	ENSPMEP00000027522	ENSPMEP00000007616	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.938
LOC106911072	LOC106927524	ENSPMEP00000027522	ENSPMEP00000006139	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.679
LOC106911072	LOC106929190	ENSPMEP00000027522	ENSPMEP00000017269	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921
LOC106911072	LOC106933633	ENSPMEP00000027522	ENSPMEP00000002682	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.679
LOC106911072	PDPK1	ENSPMEP00000027522	ENSPMEP00000034297	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1-like.	0.961
LOC106911072	SGK1	ENSPMEP00000027522	ENSPMEP00000013280	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.959
LOC106911072	akt1	ENSPMEP00000027522	ENSPMEP00000004345	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.679
LOC106911072	sgk2	ENSPMEP00000027522	ENSPMEP00000004831	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.890
LOC106911072	sgk3	ENSPMEP00000027522	ENSPMEP00000028294	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.732
LOC106911720	LOC106911072	ENSPMEP00000032988	ENSPMEP00000027522	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.961
LOC106911720	LOC106927524	ENSPMEP00000032988	ENSPMEP00000006139	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.967
LOC106911720	LOC106929190	ENSPMEP00000032988	ENSPMEP00000017269	3-phosphoinositide dependent protein kinase 1b.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.961
LOC106911720	LOC106933633	ENSPMEP00000032988	ENSPMEP00000002682	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase.	0.967
LOC106911720	SGK1	ENSPMEP00000032988	ENSPMEP00000013280	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase.	0.959
LOC106911720	akt1	ENSPMEP00000032988	ENSPMEP00000004345	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.967
LOC106911720	sgk2	ENSPMEP00000032988	ENSPMEP00000004831	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.960
LOC106911720	sgk3	ENSPMEP00000032988	ENSPMEP00000028294	3-phosphoinositide dependent protein kinase 1b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.957
LOC106914462	LOC106911072	ENSPMEP00000025901	ENSPMEP00000027522	Forkhead box O1 a.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.939