(16 nodes) COPI vesicle coat, and COPI-coated vesicle budding network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106928259	ER lumen protein-retaining receptor. (212 aa)
	arfgap3	ADP-ribosylation factor GTPase activating protein 3. (532 aa)
	gbf1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1865 aa)
	LOC106906158	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	LOC106906381	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (873 aa)
	copa	Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1222 aa)
	LOC106934100	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (938 aa)
	ENSPMEP00000019122	Proline rich 15 like b. (119 aa)
	arcn1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (508 aa)
	COPB2	WD_REPEATS_REGION domain-containing protein. (1190 aa)
	copz1	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (177 aa)
	arfgap1	ADP-ribosylation factor GTPase activating protein 1. (415 aa)
	copb1	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (953 aa)
	arfgap2	ADP-ribosylation factor GTPase activating protein 2. (532 aa)
	LOC106912034	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (236 aa)
	cope	Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (302 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPB2	ENSPMEP00000019122	ENSPMEP00000021864	ENSPMEP00000019122	WD_REPEATS_REGION domain-containing protein.	Proline rich 15 like b.	0.940
COPB2	LOC106906158	ENSPMEP00000021864	ENSPMEP00000003479	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.660
COPB2	LOC106906381	ENSPMEP00000021864	ENSPMEP00000014792	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.990
COPB2	LOC106912034	ENSPMEP00000021864	ENSPMEP00000029103	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	0.940
COPB2	LOC106928259	ENSPMEP00000021864	ENSPMEP00000000619	WD_REPEATS_REGION domain-containing protein.	ER lumen protein-retaining receptor.	0.701
COPB2	arcn1	ENSPMEP00000021864	ENSPMEP00000020413	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.994
COPB2	arfgap1	ENSPMEP00000021864	ENSPMEP00000023247	WD_REPEATS_REGION domain-containing protein.	ADP-ribosylation factor GTPase activating protein 1.	0.781
COPB2	arfgap2	ENSPMEP00000021864	ENSPMEP00000023641	WD_REPEATS_REGION domain-containing protein.	ADP-ribosylation factor GTPase activating protein 2.	0.949
COPB2	arfgap3	ENSPMEP00000021864	ENSPMEP00000001233	WD_REPEATS_REGION domain-containing protein.	ADP-ribosylation factor GTPase activating protein 3.	0.949
COPB2	copa	ENSPMEP00000021864	ENSPMEP00000014839	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.	0.995
COPB2	copb1	ENSPMEP00000021864	ENSPMEP00000023292	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.997
COPB2	cope	ENSPMEP00000021864	ENSPMEP00000034759	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family.	0.981
COPB2	copz1	ENSPMEP00000021864	ENSPMEP00000021909	WD_REPEATS_REGION domain-containing protein.	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	0.946
COPB2	gbf1	ENSPMEP00000021864	ENSPMEP00000002219	WD_REPEATS_REGION domain-containing protein.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.782
ENSPMEP00000019122	COPB2	ENSPMEP00000019122	ENSPMEP00000021864	Proline rich 15 like b.	WD_REPEATS_REGION domain-containing protein.	0.940
ENSPMEP00000019122	LOC106906158	ENSPMEP00000019122	ENSPMEP00000003479	Proline rich 15 like b.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.614
ENSPMEP00000019122	LOC106906381	ENSPMEP00000019122	ENSPMEP00000014792	Proline rich 15 like b.	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.963
ENSPMEP00000019122	LOC106928259	ENSPMEP00000019122	ENSPMEP00000000619	Proline rich 15 like b.	ER lumen protein-retaining receptor.	0.701
ENSPMEP00000019122	LOC106934100	ENSPMEP00000019122	ENSPMEP00000015388	Proline rich 15 like b.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.940
ENSPMEP00000019122	arcn1	ENSPMEP00000019122	ENSPMEP00000020413	Proline rich 15 like b.	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.968