(30 nodes) Positive regulation of insulin secretion network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPMEP00000001928	RabBD domain-containing protein. (131 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (166 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (147 aa)
	sri	Uncharacterized protein. (187 aa)
	LOC106907845	Nuclear receptor subfamily 1, group H, member 5. (421 aa)
	ENSPMEP00000030083	ACAS_N domain-containing protein. (210 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (336 aa)
	LOC106917582	Grancalcin. (242 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1108 aa)
	rfx6	Regulatory factor X, 6. (858 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC106918275	Acetoacetyl-CoA synthetase. (227 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (269 aa)
	capn10	Calpain 10; Belongs to the peptidase C2 family. (659 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (799 aa)
	LOC106906960	Si:ch211-106h4.9. (1289 aa)
	sirt6	Sirtuin 6. (390 aa)
	mcu	Mitochondrial calcium uniporter. (376 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (465 aa)
	ENSPMEP00000015645	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (300 aa)
	ENSPMEP00000015562	Nas2_N domain-containing protein. (80 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	LOC106932613	MCU domain-containing protein. (322 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (571 aa)
	LOC106905188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1188 aa)
	ENSPMEP00000011559	RabBD domain-containing protein. (170 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	c2cd2l	C2cd2 like. (704 aa)
	ENSPMEP00000005512	Rab_eff_C domain-containing protein. (692 aa)
	LOC106927621	Si:dkey-211g8.9. (262 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000001928	ENSPMEP00000005512	ENSPMEP00000001928	ENSPMEP00000005512	RabBD domain-containing protein.	Rab_eff_C domain-containing protein.	0.637
ENSPMEP00000005512	ENSPMEP00000001928	ENSPMEP00000005512	ENSPMEP00000001928	Rab_eff_C domain-containing protein.	RabBD domain-containing protein.	0.637
ENSPMEP00000030083	LOC106918275	ENSPMEP00000030083	ENSPMEP00000025989	ACAS_N domain-containing protein.	Acetoacetyl-CoA synthetase.	0.950
ENSPMEP00000030083	sirt6	ENSPMEP00000030083	ENSPMEP00000017946	ACAS_N domain-containing protein.	Sirtuin 6.	0.467
LOC106907845	nr0b2	ENSPMEP00000030783	ENSPMEP00000008512	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor subfamily 0, group B, member 2a.	0.715
LOC106917582	capn10	ENSPMEP00000028454	ENSPMEP00000023069	Grancalcin.	Calpain 10; Belongs to the peptidase C2 family.	0.516
LOC106918275	ENSPMEP00000030083	ENSPMEP00000025989	ENSPMEP00000030083	Acetoacetyl-CoA synthetase.	ACAS_N domain-containing protein.	0.950
LOC106918275	sirt6	ENSPMEP00000025989	ENSPMEP00000017946	Acetoacetyl-CoA synthetase.	Sirtuin 6.	0.467
capn10	LOC106917582	ENSPMEP00000023069	ENSPMEP00000028454	Calpain 10; Belongs to the peptidase C2 family.	Grancalcin.	0.516
capn10	sri	ENSPMEP00000023069	ENSPMEP00000031117	Calpain 10; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.516
nr0b2	LOC106907845	ENSPMEP00000008512	ENSPMEP00000030783	Nuclear receptor subfamily 0, group B, member 2a.	Nuclear receptor subfamily 1, group H, member 5.	0.715
nr0b2	nr1h4	ENSPMEP00000008512	ENSPMEP00000016332	Nuclear receptor subfamily 0, group B, member 2a.	Nuclear receptor subfamily 1, group H, member 4.	0.715
nr1h4	nr0b2	ENSPMEP00000016332	ENSPMEP00000008512	Nuclear receptor subfamily 1, group H, member 4.	Nuclear receptor subfamily 0, group B, member 2a.	0.715
sirt6	ENSPMEP00000030083	ENSPMEP00000017946	ENSPMEP00000030083	Sirtuin 6.	ACAS_N domain-containing protein.	0.467
sirt6	LOC106918275	ENSPMEP00000017946	ENSPMEP00000025989	Sirtuin 6.	Acetoacetyl-CoA synthetase.	0.467
sri	capn10	ENSPMEP00000031117	ENSPMEP00000023069	Uncharacterized protein.	Calpain 10; Belongs to the peptidase C2 family.	0.516