(87 nodes) Endocrine system development network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106926372	Paired box 2b. (347 aa)
	CDKAL1	CDK5 regulatory subunit associated protein 1 like 1. (535 aa)
	GATA2	GATA binding protein 2. (462 aa)
	LOC106907567	Uncharacterized protein. (417 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	gsx1	GS homeobox 1. (243 aa)
	LOC106928221	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (48 aa)
	LOC106905392	Paired box 2a. (391 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (305 aa)
	ENSPMEP00000002113	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	LOC106916517	Homeobox protein. (361 aa)
	ENSPMEP00000002928	BHLH domain-containing protein. (100 aa)
	ENSPMEP00000005334	Paired box 4. (326 aa)
	LOC106920957	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (545 aa)
	LOC106910517	Zgc:153993. (204 aa)
	LOC106910484	NK6 homeobox 2. (281 aa)
	srf	Serum response factor b. (601 aa)
	pax5	Paired box 5. (401 aa)
	ENSPMEP00000006410	Uncharacterized protein. (235 aa)
	LOC106905916	MNNL domain-containing protein. (165 aa)
	LOC106923054	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (405 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1034 aa)
	LOC106928804	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (469 aa)
	LOC106907994	Uncharacterized protein. (826 aa)
	ENSPMEP00000008556	COesterase domain-containing protein. (801 aa)
	wt1	WT1 transcription factor b. (422 aa)
	pax6	Paired box 6b. (420 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)
	LOC106916274	Fibronectin type-III domain-containing protein. (589 aa)
	nkx2-2	NK2 homeobox 2a. (273 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (801 aa)
	LOC106916212	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (320 aa)
	LOC106925465	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	six6	SIX homeobox 6a. (245 aa)
	LOC106924051	Uncharacterized protein. (650 aa)
	ENSPMEP00000012821	Achaete-scute family bHLH transcription factor 1b. (183 aa)
	ENSPMEP00000013137	Achaete-scute family bHLH transcription factor 1a. (183 aa)
	LOC106918115	Dickkopf WNT signaling pathway inhibitor 3a. (254 aa)
	nf1	Neurofibromin 1b. (2764 aa)
	six3	SIX homeobox 3a. (294 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3b. (259 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	LOC106908579	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	LOC106933958	T-box transcription factor 1. (498 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (779 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1577 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (255 aa)
	LOC106930411	Homeobox domain-containing protein. (224 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC106921110	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
	nkx6-1	NK6 homeobox 1. (328 aa)
	armc5	Armadillo repeat containing 5. (1132 aa)
	bsx	Brain-specific homeobox. (225 aa)
	nkx2-5	NK2 homeobox 5. (318 aa)
	LOC106933606	GATA binding protein 2a. (460 aa)
	LOC106907423	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	ENSPMEP00000025102	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (521 aa)
	neurod1	Neurogenic differentiation factor. (352 aa)
	LOC106910428	ATP-binding cassette, sub-family D (ALD), member 1. (754 aa)
	LOC106925673	T-cell acute lymphocytic leukemia 1. (392 aa)
	INSM1	INSM transcriptional repressor 1. (367 aa)
	hhex	Homeobox domain-containing protein. (302 aa)
	arx	Aristaless related homeobox a. (469 aa)
	LOC106904350	SIX homeobox 3b. (281 aa)
	rfx6	Regulatory factor X, 6. (858 aa)
	LOC106925530	Insulinoma-associated 1b. (429 aa)
	LOC106917607	SIX homeobox 7. (260 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
	gcm2	GCM domain-containing protein. (428 aa)
	LOC106914849	T-box transcription factor 2a. (588 aa)
	ENSPMEP00000029559	Homeobox domain-containing protein. (143 aa)
	med12	Mediator complex subunit 12. (2017 aa)
	pax8	Paired box 8. (470 aa)
	LOC106905652	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1105 aa)
	LOC106911867	Homeobox domain-containing protein. (273 aa)
	LOC106931781	MADS-box domain-containing protein. (472 aa)
	LOC106917985	GLUCAGON domain-containing protein. (152 aa)
	LOC106911772	T-box transcription factor TBX1-like. (498 aa)
	rax	Retinal homeobox gene 3. (297 aa)
	LOC106911737	Homeobox protein Nkx-6.2-like. (273 aa)
	LOC106931238	WT1 transcription factor a. (445 aa)
	LOC106910776	MNNL domain-containing protein. (156 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	edn1	Endothelin 1. (207 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKAL1	hhex	ENSPMEP00000000037	ENSPMEP00000025835	CDK5 regulatory subunit associated protein 1 like 1.	Homeobox domain-containing protein.	0.553
ENSPMEP00000002113	dlx3	ENSPMEP00000002113	ENSPMEP00000021190	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.405
ENSPMEP00000002113	edn1	ENSPMEP00000002113	ENSPMEP00000034629	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.521
ENSPMEP00000002113	fgf3	ENSPMEP00000002113	ENSPMEP00000034546	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.828
ENSPMEP00000002113	hand2	ENSPMEP00000002113	ENSPMEP00000008838	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.492
ENSPMEP00000002113	nkx2-5	ENSPMEP00000002113	ENSPMEP00000022530	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 5.	0.429
ENSPMEP00000002113	shh	ENSPMEP00000002113	ENSPMEP00000011350	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.568
ENSPMEP00000002113	smo	ENSPMEP00000002113	ENSPMEP00000000626	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.428
ENSPMEP00000002928	GATA2	ENSPMEP00000002928	ENSPMEP00000000423	BHLH domain-containing protein.	GATA binding protein 2.	0.785
ENSPMEP00000002928	LOC106933606	ENSPMEP00000002928	ENSPMEP00000023106	BHLH domain-containing protein.	GATA binding protein 2a.	0.785
ENSPMEP00000005334	LOC106904350	ENSPMEP00000005334	ENSPMEP00000026358	Paired box 4.	SIX homeobox 3b.	0.494
ENSPMEP00000005334	LOC106908579	ENSPMEP00000005334	ENSPMEP00000015077	Paired box 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
ENSPMEP00000005334	LOC106917607	ENSPMEP00000005334	ENSPMEP00000027979	Paired box 4.	SIX homeobox 7.	0.477
ENSPMEP00000005334	LOC106928221	ENSPMEP00000005334	ENSPMEP00000000767	Paired box 4.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.431
ENSPMEP00000005334	nf1	ENSPMEP00000005334	ENSPMEP00000014013	Paired box 4.	Neurofibromin 1b.	0.430
ENSPMEP00000005334	nkx2-2	ENSPMEP00000005334	ENSPMEP00000010185	Paired box 4.	NK2 homeobox 2a.	0.428
ENSPMEP00000005334	pdx1	ENSPMEP00000005334	ENSPMEP00000015052	Paired box 4.	Pancreatic and duodenal homeobox 1.	0.568
ENSPMEP00000006410	LOC106916274	ENSPMEP00000006410	ENSPMEP00000009635	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.423
ENSPMEP00000006410	med12	ENSPMEP00000006410	ENSPMEP00000030415	Uncharacterized protein.	Mediator complex subunit 12.	0.507
ENSPMEP00000008556	LOC106917985	ENSPMEP00000008556	ENSPMEP00000032393	COesterase domain-containing protein.	GLUCAGON domain-containing protein.	0.465