(44 nodes) Hair cell differentiation network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106907129	Potassium voltage-gated channel, KQT-like subfamily, member 1.1. (468 aa)
	LOC106926411	Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1253 aa)
	LOC106906176	Uncharacterized protein. (230 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	ENSPMEP00000032465	Whirlin a. (473 aa)
	slitrk6	SLIT and NTRK-like family, member 6. (854 aa)
	LOC106918078	PDZ domain containing 7a. (963 aa)
	pax8	Paired box 8. (470 aa)
	ENSPMEP00000030072	Uncharacterized protein. (424 aa)
	ENSPMEP00000029720	Ion_trans domain-containing protein; Belongs to the potassium channel family. (424 aa)
	cops5	COP9 signalosome subunit 5. (377 aa)
	LOC106905815	Uncharacterized protein. (574 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	LOC106918239	Protein kinase C and casein kinase substrate in neurons 1b. (443 aa)
	neurod1	Neurogenic differentiation factor. (352 aa)
	ercc2	Excision repair cross-complementation group 2. (739 aa)
	tmem132e	Transmembrane protein 132E. (687 aa)
	ENSPMEP00000021595	PDZ domain-containing protein. (132 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC106906138	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1248 aa)
	pacsin1	Protein kinase C and casein kinase substrate in neurons 1a. (439 aa)
	LOC106927839	Transmembrane O-methyltransferase. (259 aa)
	ENSPMEP00000018667	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1038 aa)
	LOC106915392	Uncharacterized protein. (472 aa)
	tprn	Taperin. (742 aa)
	znrf3	Zinc and ring finger 3. (855 aa)
	ENSPMEP00000013920	PDZ domain-containing protein. (181 aa)
	gsdme	Gasdermin Eb. (461 aa)
	LOC106905392	Paired box 2a. (391 aa)
	clrn2	Clarin 2. (231 aa)
	ptprq	Protein tyrosine phosphatase receptor type Q. (2244 aa)
	atp6v0d1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
	slc44a4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (718 aa)
	wdpcp	WD repeat containing planar cell polarity effector. (693 aa)
	pax5	Paired box 5. (401 aa)
	dctn2	Dynactin 2 (p50). (403 aa)
	LOC106926372	Paired box 2b. (347 aa)
	LOC106926233	Cordon-bleu WH2 repeat protein. (1512 aa)
	ENSPMEP00000009883	Glutaredoxin and cysteine rich domain containing 1 b. (130 aa)
	LOC106910184	Usher syndrome 2A (autosomal recessive, mild). (4797 aa)
	ENSPMEP00000010849	PDZ domain-containing protein. (108 aa)
	ENSPMEP00000011566	Glutaredoxin and cysteine rich domain containing 1 a. (190 aa)
	ush1c	Usher syndrome 1C. (553 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	ENSPMEP00000018667	ENSPMEP00000027808	ENSPMEP00000018667	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.900
CDH2	ush1c	ENSPMEP00000027808	ENSPMEP00000012419	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Usher syndrome 1C.	0.444
ENSPMEP00000009883	LOC106906176	ENSPMEP00000009883	ENSPMEP00000034726	Glutaredoxin and cysteine rich domain containing 1 b.	Uncharacterized protein.	0.632
ENSPMEP00000009883	ush1c	ENSPMEP00000009883	ENSPMEP00000012419	Glutaredoxin and cysteine rich domain containing 1 b.	Usher syndrome 1C.	0.443
ENSPMEP00000010849	LOC106910184	ENSPMEP00000010849	ENSPMEP00000010529	PDZ domain-containing protein.	Usher syndrome 2A (autosomal recessive, mild).	0.496
ENSPMEP00000010849	mib1	ENSPMEP00000010849	ENSPMEP00000018603	PDZ domain-containing protein.	Mindbomb E3 ubiquitin protein ligase 1.	0.407
ENSPMEP00000011566	LOC106906176	ENSPMEP00000011566	ENSPMEP00000034726	Glutaredoxin and cysteine rich domain containing 1 a.	Uncharacterized protein.	0.632
ENSPMEP00000011566	ush1c	ENSPMEP00000011566	ENSPMEP00000012419	Glutaredoxin and cysteine rich domain containing 1 a.	Usher syndrome 1C.	0.443
ENSPMEP00000013920	ENSPMEP00000030072	ENSPMEP00000013920	ENSPMEP00000030072	PDZ domain-containing protein.	Uncharacterized protein.	0.699
ENSPMEP00000013920	LOC106910184	ENSPMEP00000013920	ENSPMEP00000010529	PDZ domain-containing protein.	Usher syndrome 2A (autosomal recessive, mild).	0.532
ENSPMEP00000018667	CDH2	ENSPMEP00000018667	ENSPMEP00000027808	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.900
ENSPMEP00000018667	ush1c	ENSPMEP00000018667	ENSPMEP00000012419	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Usher syndrome 1C.	0.444
ENSPMEP00000021595	LOC106910184	ENSPMEP00000021595	ENSPMEP00000010529	PDZ domain-containing protein.	Usher syndrome 2A (autosomal recessive, mild).	0.496
ENSPMEP00000021595	mib1	ENSPMEP00000021595	ENSPMEP00000018603	PDZ domain-containing protein.	Mindbomb E3 ubiquitin protein ligase 1.	0.407
ENSPMEP00000029720	LOC106907129	ENSPMEP00000029720	ENSPMEP00000012462	Ion_trans domain-containing protein; Belongs to the potassium channel family.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1.	0.904
ENSPMEP00000030072	ENSPMEP00000013920	ENSPMEP00000030072	ENSPMEP00000013920	Uncharacterized protein.	PDZ domain-containing protein.	0.699
ENSPMEP00000030072	LOC106910184	ENSPMEP00000030072	ENSPMEP00000010529	Uncharacterized protein.	Usher syndrome 2A (autosomal recessive, mild).	0.532
ENSPMEP00000032465	LOC106910184	ENSPMEP00000032465	ENSPMEP00000010529	Whirlin a.	Usher syndrome 2A (autosomal recessive, mild).	0.496
ENSPMEP00000032465	mib1	ENSPMEP00000032465	ENSPMEP00000018603	Whirlin a.	Mindbomb E3 ubiquitin protein ligase 1.	0.407
LOC106905815	LOC106910184	ENSPMEP00000027977	ENSPMEP00000010529	Uncharacterized protein.	Usher syndrome 2A (autosomal recessive, mild).	0.496