(36 nodes) Response to alkaloid network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	casp6	Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (292 aa)
	LOC106921753	Ryanodine receptor 1a (skeletal). (4989 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
	ppp1r1b	Protein phosphatase 1, regulatory (inhibitor) subunit 1B. (237 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (895 aa)
	ENSPMEP00000006064	B30.2/SPRY domain-containing protein. (316 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (170 aa)
	LOC106904784	Serine and arginine rich splicing factor 9. (251 aa)
	ENSPMEP00000007642	B30.2/SPRY domain-containing protein. (329 aa)
	LOC106921631	Amino acid transporter. (544 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	HOMER1	Homer scaffold protein 1. (356 aa)
	LOC106905188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1188 aa)
	drd3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	slc1a2	Amino acid transporter. (558 aa)
	ENSPMEP00000015645	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (300 aa)
	LOC106921283	Homer scaffold protein 1b. (379 aa)
	LOC106914748	Ubiquitin protein ligase E3A. (819 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (779 aa)
	drd4	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	LOC106931758	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	LOC106906199	Uncharacterized protein. (1004 aa)
	recql5	RecQ helicase-like 5. (1007 aa)
	LOC106916660	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1460 aa)
	LOC106925716	Amino acid transporter. (675 aa)
	ENSPMEP00000024896	Ins145_P3_rec domain-containing protein. (112 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1108 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	ENSPMEP00000028239	B30.2/SPRY domain-containing protein. (345 aa)
	ENSPMEP00000028260	Ins145_P3_rec domain-containing protein. (149 aa)
	blm	BLM RecQ like helicase. (1396 aa)
	LOC106932657	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	LOC106914059	Ryanodine receptor 2b (cardiac). (4613 aa)
	spidr	Uncharacterized protein. (934 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000006064	ENSPMEP00000024896	ENSPMEP00000006064	ENSPMEP00000024896	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.829
ENSPMEP00000006064	ENSPMEP00000028260	ENSPMEP00000006064	ENSPMEP00000028260	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.778
ENSPMEP00000007642	ENSPMEP00000024896	ENSPMEP00000007642	ENSPMEP00000024896	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.820
ENSPMEP00000007642	ENSPMEP00000028260	ENSPMEP00000007642	ENSPMEP00000028260	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.772
ENSPMEP00000024896	ENSPMEP00000006064	ENSPMEP00000024896	ENSPMEP00000006064	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.829
ENSPMEP00000024896	ENSPMEP00000007642	ENSPMEP00000024896	ENSPMEP00000007642	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.820
ENSPMEP00000024896	ENSPMEP00000028239	ENSPMEP00000024896	ENSPMEP00000028239	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.785
ENSPMEP00000028239	ENSPMEP00000024896	ENSPMEP00000028239	ENSPMEP00000024896	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.785
ENSPMEP00000028239	ENSPMEP00000028260	ENSPMEP00000028239	ENSPMEP00000028260	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.755
ENSPMEP00000028260	ENSPMEP00000006064	ENSPMEP00000028260	ENSPMEP00000006064	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.778
ENSPMEP00000028260	ENSPMEP00000007642	ENSPMEP00000028260	ENSPMEP00000007642	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.772
ENSPMEP00000028260	ENSPMEP00000028239	ENSPMEP00000028260	ENSPMEP00000028239	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.755
LOC106906199	LOC106914059	ENSPMEP00000020534	ENSPMEP00000032214	Uncharacterized protein.	Ryanodine receptor 2b (cardiac).	0.892
LOC106914059	LOC106906199	ENSPMEP00000032214	ENSPMEP00000020534	Ryanodine receptor 2b (cardiac).	Uncharacterized protein.	0.892
LOC106914748	UBE3A	ENSPMEP00000017651	ENSPMEP00000001968	Ubiquitin protein ligase E3A.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.921
LOC106921631	abat	ENSPMEP00000007854	ENSPMEP00000010908	Amino acid transporter.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.502
LOC106925716	abat	ENSPMEP00000024822	ENSPMEP00000010908	Amino acid transporter.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.502
LOC106931758	drd3	ENSPMEP00000019737	ENSPMEP00000014232	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.744
PPP1R1B	cdk5	ENSPMEP00000006881	ENSPMEP00000014717	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.794
UBE3A	LOC106914748	ENSPMEP00000001968	ENSPMEP00000017651	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Ubiquitin protein ligase E3A.	0.921