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dph2 dph2 dna2 dna2 ppat ppat LOC106930075 LOC106930075 NDUFS8 NDUFS8 dph1 dph1 LOC106907191 LOC106907191 LOC106914879 LOC106914879 nthl1 nthl1 nubp2 nubp2 ENSPMEP00000013594 ENSPMEP00000013594 prim2 prim2 LOC106907034 LOC106907034 pold1 pold1 tyw1 tyw1 cdk5rap1 cdk5rap1 elp3 elp3 ndufs2 ndufs2 LOC106926553 LOC106926553 mocs1 mocs1 CDKAL1 CDKAL1 MUTYH MUTYH lias lias rtel1 rtel1 LOC106906708 LOC106906708 rsad2 rsad2 ireb2 ireb2 isca2 isca2 ercc2 ercc2 ciapin1 ciapin1 serp1 serp1 dpyd dpyd SDHB SDHB ddx11 ddx11 ino80d ino80d NDUFS1 NDUFS1 NDUFV1 NDUFV1 LOC106928075 LOC106928075 brip1 brip1 LOC106904647 LOC106904647 aco1 aco1 etfdh etfdh ndufs7 ndufs7 ACO2 ACO2 ciao3 ciao3 LOC106919953 LOC106919953 ENSPMEP00000032240 ENSPMEP00000032240 POLE POLE rsad1 rsad1 nubpl nubpl LOC106914996 LOC106914996
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dph22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (490 aa)
dna2Uncharacterized protein. (1356 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
LOC106930075Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (782 aa)
NDUFS8NADH:ubiquinone oxidoreductase core subunit S8. (208 aa)
dph12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (405 aa)
LOC106907191NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (756 aa)
LOC106914879NCK associated protein 5. (1916 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (317 aa)
nubp2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (268 aa)
ENSPMEP00000013594Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (88 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa)
LOC106907034Uncharacterized protein. (212 aa)
pold1DNA polymerase. (1105 aa)
tyw1tRNA-yW synthesizing protein 1 homolog (S. cerevisiae). (747 aa)
cdk5rap1CDK5 regulatory subunit associated protein 1. (580 aa)
elp3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (538 aa)
ndufs2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (498 aa)
LOC106926553Uncharacterized protein; Belongs to the complex I 75 kDa subunit family. (731 aa)
mocs1Molybdenum cofactor synthesis 1. (397 aa)
CDKAL1CDK5 regulatory subunit associated protein 1 like 1. (535 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (523 aa)
liasLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (393 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1180 aa)
LOC106906708Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (322 aa)
rsad2Radical S-adenosyl methionine domain containing 2. (350 aa)
ireb2Iron-responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (987 aa)
isca2Iron-sulfur cluster assembly 2. (203 aa)
ercc2Excision repair cross-complementation group 2. (739 aa)
ciapin1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (313 aa)
serp1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
dpydDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1026 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (283 aa)
ddx11DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (902 aa)
ino80dINO80 complex subunit Da. (1007 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (739 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (459 aa)
LOC106928075Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (279 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (820 aa)
LOC106904647Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
aco1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (820 aa)
etfdhElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
ndufs7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (220 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
ciao3Nuclear prelamin A recognition factor-like; Belongs to the NARF family. (476 aa)
LOC106919953NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (472 aa)
ENSPMEP00000032240DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (364 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1123 aa)
rsad1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (466 aa)
nubplNucleotide binding protein-like. (349 aa)
LOC106914996NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). (254 aa)
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
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