(137 nodes) Regulation of ERK1 and ERK2 cascade network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106924591	JunE proto-oncogene, AP-1 transcription factor subunit. (323 aa)
	LOC106922153	Neuroplastin b. (394 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)
	LOC106927746	SERPIN domain-containing protein; Belongs to the serpin family. (481 aa)
	LOC106927732	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (389 aa)
	LOC106932994	Protein tyrosine phosphatase non-receptor type 11b. (584 aa)
	LOC106904534	CARD domain-containing protein. (520 aa)
	bmp4	Bone morphogenetic protein 4. (400 aa)
	LOC106909855	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	ENSPMEP00000002854	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (65 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	ENSPMEP00000003185	C-C motif chemokine. (112 aa)
	LOC106919835	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	abl2	Tyrosine-protein kinase. (1180 aa)
	fgb	Fibrinogen beta chain. (493 aa)
	LOC106917838	Uncharacterized protein. (463 aa)
	LOC106907399	Uncharacterized protein. (420 aa)
	LOC106928125	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC106925098	Sprouty RTK signaling antagonist 4. (381 aa)
	ENSPMEP00000004544	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (428 aa)
	LOC106919778	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (561 aa)
	C5AR1	Complement C5a receptor 1. (350 aa)
	LOC106905232	Protein tyrosine phosphatase non-receptor type 6. (583 aa)
	ENSPMEP00000004930	Pyrin domain-containing protein. (118 aa)
	LOC106932835	Uncharacterized protein. (165 aa)
	ENSPMEP00000006009	Tumor necrosis factor, alpha-induced protein 8-like 3. (190 aa)
	PTPN2	Protein tyrosine phosphatase non-receptor type 2. (175 aa)
	LOC106934335	ERBB receptor feedback inhibitor 1a. (419 aa)
	LOC106926905	Uncharacterized protein. (471 aa)
	ENSPMEP00000008267	Tumor necrosis factor, alpha-induced protein 8-like 3. (190 aa)
	prxl2c	Peroxiredoxin like 2C. (230 aa)
	RAMP3	Receptor activity modifying protein 3. (162 aa)
	LOC106926271	ALK and LTK ligand 1. (157 aa)
	ENSPMEP00000009222	Uncharacterized protein. (627 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	styx	Serine/threonine/tyrosine interacting protein. (224 aa)
	LOC106904990	SCY domain-containing protein. (116 aa)
	LOC106905000	Uncharacterized protein. (99 aa)
	tnip1	TNFAIP3 interacting protein 1. (657 aa)
	garem2	GRB2 associated, regulator of MAPK1-like. (708 aa)
	LOC106920166	Bone morphogenetic protein 16. (509 aa)
	ENSPMEP00000011268	Uncharacterized protein. (920 aa)
	LOC106920154	Uncharacterized protein; Belongs to the semaphorin family. (610 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (495 aa)
	alkal2	Uncharacterized protein. (157 aa)
	ptprc	Uncharacterized protein. (726 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (231 aa)
	ENSPMEP00000013664	A kinase (PRKA) anchor protein 12b. (1407 aa)
	fgf21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	LOC106932642	Si:ch73-330k17.3. (167 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	gper1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	flcn	Folliculin. (554 aa)
	LOC106920633	Sprouty RTK signaling antagonist 2. (347 aa)
	apela	Apelin receptor early endogenous ligand. (54 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (658 aa)
	LOC106909302	Mothers against decapentaplegic homolog. (534 aa)
	dusp10	Dual specificity phosphatase 10. (472 aa)
	nox4	FAD-binding FR-type domain-containing protein. (560 aa)
	LOC106908506	Apolipoprotein Eb. (265 aa)
	LOC106932496	Rap guanine nucleotide exchange factor (GEF) 2. (1453 aa)
	glipr2	GLI pathogenesis-related 2, like; Belongs to the CRISP family. (163 aa)
	ENSPMEP00000017641	Uncharacterized protein. (275 aa)
	ENSPMEP00000034664	SCY domain-containing protein. (91 aa)
	LOC106931722-2	SCY domain-containing protein. (91 aa)
	LOC106923631	Apolipoprotein Ea. (251 aa)
	ENSPMEP00000034535	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
	LOC106931735	SCY domain-containing protein. (144 aa)
	LOC106913959	C18h3orf33 homolog (H. sapiens). (268 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (294 aa)
	dab2	DAB adaptor protein 2. (751 aa)
	gas6	Uncharacterized protein. (650 aa)
	vrk3	VRK serine/threonine kinase 3. (525 aa)
	LOC106904808	Tyrosine-protein phosphatase non-receptor type. (404 aa)
	ccn2	Cellular communication network factor 2a. (346 aa)
	LOC106919996	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	SPRY4	Protein sprouty homolog 4-like. (381 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (581 aa)
	LOC106920010	Si:ch211-153j24.3. (375 aa)
	LOC106904187	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (466 aa)
	ENSPMEP00000030735	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	traf7	TNF receptor-associated factor 7. (690 aa)
	LOC106911966	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (361 aa)
	LOC106929377	Protein kinase domain-containing protein. (2555 aa)
	LOC106923514	Mothers against decapentaplegic homolog. (503 aa)
	ENSPMEP00000027754	SCY domain-containing protein. (127 aa)
	LOC106904991	SCY domain-containing protein. (97 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	ACKR3	Atypical chemokine receptor 3. (370 aa)
	LOC106928732	Zgc:171965; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	abl1	Tyrosine-protein kinase. (1117 aa)
	ENSPMEP00000026384	C-C motif chemokine. (123 aa)
	bmper	BMP binding endothelial regulator. (692 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (606 aa)
	LOC106920376	Si:ch211-113g11.6; Belongs to the semaphorin family. (471 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (203 aa)
	LOC106920963	Uncharacterized protein. (630 aa)
	LOC106917078	SCY domain-containing protein. (131 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	ENSPMEP00000024051	Tyrosine-protein phosphatase domain-containing protein. (172 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (228 aa)
	phb	Prohibitin. (271 aa)
	LOC106910647	Uncharacterized protein. (377 aa)
	LOC106916451	C-C motif chemokine. (97 aa)
	LOC106906873	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	LOC106921783	Elastin microfibril interfacer 1a. (1021 aa)
	jun	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (288 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1026 aa)
	LOC106904598	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	ENSPMEP00000021822	EMI domain-containing protein. (419 aa)
	LOC106917213	Fibronectin 1a. (2487 aa)
	atf3	Activating transcription factor 3. (257 aa)
	LOC106916778	Tyrosine-protein phosphatase non-receptor type. (431 aa)
	garem1	GRB2 associated, regulator of MAPK1. (869 aa)
	LOC106922645	Si:dkey-175m17.7. (879 aa)
	LOC106931721	SCY domain-containing protein. (93 aa)
	LOC106931722	C-C motif chemokine. (91 aa)
	ENSPMEP00000020826	SCY domain-containing protein. (89 aa)
	LOC106931736	SCY domain-containing protein. (95 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (941 aa)
	ENSPMEP00000020245	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	LOC106911598	Uncharacterized protein. (1075 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (653 aa)
	LOC106909961	Uncharacterized protein. (1248 aa)
	LOC106907688	Interleukin-1. (247 aa)
	LOC106906265	Family with sequence similarity 83 member D. (540 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	ENSPMEP00000018794	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	ENSPMEP00000018793	C-C motif chemokine. (93 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (996 aa)
	ccn1	Cellular communication network factor 1. (376 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (477 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (217 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR3	ENSPMEP00000020826	ENSPMEP00000027279	ENSPMEP00000020826	Atypical chemokine receptor 3.	SCY domain-containing protein.	0.543
ACKR3	LOC106919835	ENSPMEP00000027279	ENSPMEP00000003576	Atypical chemokine receptor 3.	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family.	0.901
ACKR3	LOC106931722-2	ENSPMEP00000027279	ENSPMEP00000034660	Atypical chemokine receptor 3.	SCY domain-containing protein.	0.433
ACKR3	LOC106931735	ENSPMEP00000027279	ENSPMEP00000034479	Atypical chemokine receptor 3.	SCY domain-containing protein.	0.669
ACKR3	LOC106931736	ENSPMEP00000027279	ENSPMEP00000020567	Atypical chemokine receptor 3.	SCY domain-containing protein.	0.582
C5AR1	LOC106928732	ENSPMEP00000004677	ENSPMEP00000027216	Complement C5a receptor 1.	Zgc:171965; Belongs to the G-protein coupled receptor 1 family.	0.660
ENSPMEP00000002854	ENSPMEP00000018794	ENSPMEP00000002854	ENSPMEP00000018794	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
ENSPMEP00000002854	LOC106905232	ENSPMEP00000002854	ENSPMEP00000004820	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Protein tyrosine phosphatase non-receptor type 6.	0.404
ENSPMEP00000002854	LOC106909855	ENSPMEP00000002854	ENSPMEP00000002818	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.676
ENSPMEP00000002854	LOC106928125	ENSPMEP00000002854	ENSPMEP00000004401	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.430
ENSPMEP00000002854	LOC106932994	ENSPMEP00000002854	ENSPMEP00000001892	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Protein tyrosine phosphatase non-receptor type 11b.	0.404
ENSPMEP00000002854	ptpn11	ENSPMEP00000002854	ENSPMEP00000003082	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.404
ENSPMEP00000003185	ENSPMEP00000026384	ENSPMEP00000003185	ENSPMEP00000026384	C-C motif chemokine.	C-C motif chemokine.	0.702
ENSPMEP00000004544	LOC106904598	ENSPMEP00000004544	ENSPMEP00000021830	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.850
ENSPMEP00000004544	LOC106905232	ENSPMEP00000004544	ENSPMEP00000004820	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Protein tyrosine phosphatase non-receptor type 6.	0.417
ENSPMEP00000004544	LOC106932994	ENSPMEP00000004544	ENSPMEP00000001892	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Protein tyrosine phosphatase non-receptor type 11b.	0.417
ENSPMEP00000004544	igf1	ENSPMEP00000004544	ENSPMEP00000013349	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Insulin-like growth factor 1.	0.725
ENSPMEP00000004544	pdgfa	ENSPMEP00000004544	ENSPMEP00000023793	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.850
ENSPMEP00000004544	pdgfc	ENSPMEP00000004544	ENSPMEP00000028735	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.837
ENSPMEP00000004544	ptpn11	ENSPMEP00000004544	ENSPMEP00000003082	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.417