(33 nodes) Protein K63-linked ubiquitination network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	itch	E3 ubiquitin-protein ligase. (869 aa)
	LOC106929314	UBIQUITIN_CONJUGAT_2 domain-containing protein. (93 aa)
	LOC106931442	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
	rnf126	RING-type domain-containing protein. (325 aa)
	LOC106933514	TRAF3 interacting protein 2-like. (432 aa)
	arih2	RBR-type E3 ubiquitin transferase. (513 aa)
	LOC106917048	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (599 aa)
	ENSPMEP00000023959	RING-type domain-containing protein. (114 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	LOC106903329	SEFIR domain-containing protein. (407 aa)
	LOC106912622	UBIQUITIN_CONJUGAT_2 domain-containing protein. (184 aa)
	LOC106909247	Itchy E3 ubiquitin protein ligase b. (331 aa)
	ube2n	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (514 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (443 aa)
	LOC106931240	Si:ch211-113e8.10. (763 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (524 aa)
	LOC106919377	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	LOC106918175	Si:ch211-81a5.1. (258 aa)
	rnf4	RING-type domain-containing protein. (198 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1414 aa)
	prpf19	Pre-mRNA processing factor 19. (505 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	BFAR	Bifunctional apoptosis regulator. (457 aa)
	ENSPMEP00000005626	Uncharacterized protein. (94 aa)
	LOC106905429	Ring finger protein 126. (312 aa)
	LOC106916803	Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
	ube2g1	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
	rnf115	Ring finger protein 115. (314 aa)
	rnf152	Ring finger protein 152. (174 aa)
	LOC106930528	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (629 aa)
	hectd1	HECT domain containing 1. (2533 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	LOC106912622	ENSPMEP00000006172	ENSPMEP00000018260	Bifunctional apoptosis regulator.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.450
BFAR	LOC106916803	ENSPMEP00000006172	ENSPMEP00000000723	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 1.	0.486
BFAR	LOC106919377	ENSPMEP00000006172	ENSPMEP00000014074	Bifunctional apoptosis regulator.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.425
BFAR	LOC106929314	ENSPMEP00000006172	ENSPMEP00000029918	Bifunctional apoptosis regulator.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.486
BFAR	rnf8	ENSPMEP00000006172	ENSPMEP00000016260	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.568
BFAR	ube2n	ENSPMEP00000006172	ENSPMEP00000016381	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.425
BFAR	ube2v2	ENSPMEP00000006172	ENSPMEP00000020807	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 2.	0.450
ENSPMEP00000005626	LOC106917048	ENSPMEP00000005626	ENSPMEP00000024629	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.602
ENSPMEP00000005626	LOC106919377	ENSPMEP00000005626	ENSPMEP00000014074	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.513
ENSPMEP00000005626	LOC106930528	ENSPMEP00000005626	ENSPMEP00000032556	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.602
ENSPMEP00000005626	itch	ENSPMEP00000005626	ENSPMEP00000031496	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.898
ENSPMEP00000005626	traf2	ENSPMEP00000005626	ENSPMEP00000014402	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.602
ENSPMEP00000005626	traf3	ENSPMEP00000005626	ENSPMEP00000006298	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.594
ENSPMEP00000005626	traf6	ENSPMEP00000005626	ENSPMEP00000012334	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.858
ENSPMEP00000005626	ube2n	ENSPMEP00000005626	ENSPMEP00000016381	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.513
ENSPMEP00000023959	LOC106905429	ENSPMEP00000023959	ENSPMEP00000001316	RING-type domain-containing protein.	Ring finger protein 126.	0.425
ENSPMEP00000023959	LOC106912622	ENSPMEP00000023959	ENSPMEP00000018260	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.590
ENSPMEP00000023959	LOC106916803	ENSPMEP00000023959	ENSPMEP00000000723	RING-type domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 1.	0.486
ENSPMEP00000023959	LOC106919377	ENSPMEP00000023959	ENSPMEP00000014074	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.927
ENSPMEP00000023959	LOC106929314	ENSPMEP00000023959	ENSPMEP00000029918	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.486