(56 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Poecilia mexicana)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106927210	Signal transducer and activator of transcription. (785 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
	LOC106924395	Signal transducer and activator of transcription. (801 aa)
	LOC106927107	Runt-related transcription factor. (464 aa)
	LOC106907458	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	tbx19	Uncharacterized protein. (407 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (627 aa)
	tbx15	T-box transcription factor 15. (614 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (586 aa)
	LOC106914971	Signal transducer and activator of transcription. (723 aa)
	LOC106918207	Runt-related transcription factor. (420 aa)
	LOC106931947	Recombination signal binding protein for immunoglobulin kappa J region-like. (495 aa)
	LOC106921527	T-box transcription factor Ta. (416 aa)
	ENSPMEP00000010696	RHD domain-containing protein. (69 aa)
	relb	V-rel avian reticuloendotheliosis viral oncogene homolog B. (576 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (490 aa)
	LOC106918123	Nuclear factor of activated T cells 5b. (1338 aa)
	tbr1	T-box brain transcription factor 1b. (667 aa)
	stat3	Signal transducer and activator of transcription. (787 aa)
	LOC106931287	Signal transducer and activator of transcription. (787 aa)
	LOC106904665	Runt domain-containing protein. (302 aa)
	ENSPMEP00000021537	Uncharacterized protein. (389 aa)
	LOC106927669	Nuclear factor of activated T cells 2a. (879 aa)
	LOC106929020	RHD domain-containing protein. (880 aa)
	REL	REL proto-oncogene, NF-kB subunit. (641 aa)
	ENSPMEP00000024723	Uncharacterized protein. (334 aa)
	ENSPMEP00000025655	Uncharacterized protein. (143 aa)
	TBX22	T-box transcription factor 22. (286 aa)
	tbx3	T-box transcription factor 3a. (703 aa)
	nfkb2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (901 aa)
	LOC106924243	T-box transcription factor 5a. (517 aa)
	nfatc3	Nuclear factor of activated T cells 3a. (1092 aa)
	LOC106916248	Recombination signal binding protein for immunoglobulin kappa J region a. (488 aa)
	LOC106904976	T-box transcription factor 18. (517 aa)
	LOC106930719	Uncharacterized protein. (530 aa)
	LOC106923441	RHD domain-containing protein. (939 aa)
	LOC106914849	T-box transcription factor 2a. (588 aa)
	LOC106927865	T-box transcription factor 16. (461 aa)
	ENSPMEP00000031856	Uncharacterized protein. (210 aa)
	ENSPMEP00000032656	Myelin regulatory factor. (651 aa)
	LOC106926600	Nuclear factor of activated T cells 5a. (1402 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (627 aa)
	stat1	Signal transducer and activator of transcription. (761 aa)
	LOC106907676	Signal transducer and activator of transcription. (694 aa)
	ENSPMEP00000033996	SH2 domain-containing protein. (293 aa)
	LOC106933812	Eomesodermin homolog a. (652 aa)
	LOC106932622	T-box transcription factor 4. (549 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	LOC106903560	Nuclear factor of activated T cells 4. (891 aa)
	tbxt	T-box transcription factor Tb. (436 aa)
	LOC106933958	T-box transcription factor 1. (498 aa)
	eomes	Eomesodermin homolog b. (600 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	myrfl	Myelin regulatory factor like. (960 aa)
	LOC106911578	Runt domain-containing protein. (189 aa)
	tbx20	T-box transcription factor 20. (439 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000010696	LOC106907458	ENSPMEP00000010696	ENSPMEP00000003079	RHD domain-containing protein.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.990
ENSPMEP00000010696	REL	ENSPMEP00000010696	ENSPMEP00000022809	RHD domain-containing protein.	REL proto-oncogene, NF-kB subunit.	0.910
ENSPMEP00000010696	nfkb2	ENSPMEP00000010696	ENSPMEP00000026793	RHD domain-containing protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.907
ENSPMEP00000010696	relb	ENSPMEP00000010696	ENSPMEP00000010901	RHD domain-containing protein.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.976
ENSPMEP00000010696	tbx21	ENSPMEP00000010696	ENSPMEP00000019200	RHD domain-containing protein.	T-box transcription factor 21.	0.439
ENSPMEP00000010696	tp53	ENSPMEP00000010696	ENSPMEP00000001243	RHD domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.614
ENSPMEP00000021537	LOC106904665	ENSPMEP00000021537	ENSPMEP00000021305	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000021537	LOC106911578	ENSPMEP00000021537	ENSPMEP00000020594	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000021537	LOC106918207	ENSPMEP00000021537	ENSPMEP00000009839	Uncharacterized protein.	Runt-related transcription factor.	0.409
ENSPMEP00000021537	LOC106927107	ENSPMEP00000021537	ENSPMEP00000002723	Uncharacterized protein.	Runt-related transcription factor.	0.409
ENSPMEP00000024723	LOC106904665	ENSPMEP00000024723	ENSPMEP00000021305	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000024723	LOC106911578	ENSPMEP00000024723	ENSPMEP00000020594	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000024723	LOC106918207	ENSPMEP00000024723	ENSPMEP00000009839	Uncharacterized protein.	Runt-related transcription factor.	0.409
ENSPMEP00000024723	LOC106927107	ENSPMEP00000024723	ENSPMEP00000002723	Uncharacterized protein.	Runt-related transcription factor.	0.409
ENSPMEP00000025655	LOC106904665	ENSPMEP00000025655	ENSPMEP00000021305	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000025655	LOC106911578	ENSPMEP00000025655	ENSPMEP00000020594	Uncharacterized protein.	Runt domain-containing protein.	0.409
ENSPMEP00000025655	LOC106916248	ENSPMEP00000025655	ENSPMEP00000027735	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.434
ENSPMEP00000025655	LOC106918207	ENSPMEP00000025655	ENSPMEP00000009839	Uncharacterized protein.	Runt-related transcription factor.	0.409
ENSPMEP00000025655	LOC106921527	ENSPMEP00000025655	ENSPMEP00000010591	Uncharacterized protein.	T-box transcription factor Ta.	0.412
ENSPMEP00000025655	LOC106927107	ENSPMEP00000025655	ENSPMEP00000002723	Uncharacterized protein.	Runt-related transcription factor.	0.409