(27 nodes) Translesion synthesis by POLK network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc3	Replication factor C (activator 1) 3. (376 aa)
	rpa3	Replication protein A3. (122 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (554 aa)
	LOC106905387	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (2911 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (282 aa)
	kxd1	KxDL motif containing 1. (186 aa)
	LOC106914402	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	atad5	AAA domain-containing protein. (825 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rpa2	Replication protein A2. (278 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (195 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC106923389	Ubiquitin-like domain-containing protein. (77 aa)
	LOC106934012	ATPase family AAA domain containing 5a. (1813 aa)
	LOC106915420	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	meiob	Methionine sulfoxide reductase B1b. (450 aa)
	LOC106906886	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (638 aa)
	rev1	REV1 DNA directed polymerase. (1360 aa)
	rfc1	Replication factor C subunit 1. (1167 aa)
	LOC106910889	Rep_fac-A_C domain-containing protein. (220 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ENSPMEP00000030828	Ubiquitin-like domain-containing protein. (112 aa)
	polk	Polymerase (DNA directed) kappa. (898 aa)
	LOC106906255	RPA_C domain-containing protein. (255 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000030828	LOC106906255	ENSPMEP00000030828	ENSPMEP00000033612	Ubiquitin-like domain-containing protein.	RPA_C domain-containing protein.	0.601
ENSPMEP00000030828	LOC106923389	ENSPMEP00000030828	ENSPMEP00000014676	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.982
ENSPMEP00000030828	pcna	ENSPMEP00000030828	ENSPMEP00000006790	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.940
ENSPMEP00000030828	polk	ENSPMEP00000030828	ENSPMEP00000031942	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed) kappa.	0.789
ENSPMEP00000030828	rev1	ENSPMEP00000030828	ENSPMEP00000024165	Ubiquitin-like domain-containing protein.	REV1 DNA directed polymerase.	0.925
ENSPMEP00000030828	rev3l	ENSPMEP00000030828	ENSPMEP00000006437	Ubiquitin-like domain-containing protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.662
ENSPMEP00000030828	rfc2	ENSPMEP00000030828	ENSPMEP00000010964	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 2.	0.631
ENSPMEP00000030828	rfc3	ENSPMEP00000030828	ENSPMEP00000000253	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 3.	0.631
ENSPMEP00000030828	rfc4	ENSPMEP00000030828	ENSPMEP00000021622	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 4.	0.631
ENSPMEP00000030828	rfc5	ENSPMEP00000030828	ENSPMEP00000012673	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 5.	0.631
ENSPMEP00000030828	rpa2	ENSPMEP00000030828	ENSPMEP00000011115	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.601
ENSPMEP00000030828	rps27a	ENSPMEP00000030828	ENSPMEP00000029582	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.997
LOC106905387	rps27a	ENSPMEP00000005068	ENSPMEP00000029582	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1.	Ribosomal protein S27a.	0.432
LOC106906255	ENSPMEP00000030828	ENSPMEP00000033612	ENSPMEP00000030828	RPA_C domain-containing protein.	Ubiquitin-like domain-containing protein.	0.601
LOC106906255	LOC106906886	ENSPMEP00000033612	ENSPMEP00000022609	RPA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.972
LOC106906255	LOC106910889	ENSPMEP00000033612	ENSPMEP00000028128	RPA_C domain-containing protein.	Rep_fac-A_C domain-containing protein.	0.972
LOC106906255	LOC106915420	ENSPMEP00000033612	ENSPMEP00000017706	RPA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.979
LOC106906255	LOC106923389	ENSPMEP00000033612	ENSPMEP00000014676	RPA_C domain-containing protein.	Ubiquitin-like domain-containing protein.	0.689
LOC106906255	LOC106934012	ENSPMEP00000033612	ENSPMEP00000016741	RPA_C domain-containing protein.	ATPase family AAA domain containing 5a.	0.688
LOC106906255	atad5	ENSPMEP00000033612	ENSPMEP00000010424	RPA_C domain-containing protein.	AAA domain-containing protein.	0.688