(45 nodes) Mismatch repair network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (728 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (468 aa)
	LOC106906255	RPA_C domain-containing protein. (255 aa)
	ssbp1	Single-stranded DNA binding protein 1. (147 aa)
	yju2	YJU2 splicing factor homolog. (341 aa)
	shd	Src homology 2 domain containing transforming protein D, a. (417 aa)
	LOC106924131	Exonuclease domain-containing protein. (192 aa)
	LOC106910889	Rep_fac-A_C domain-containing protein. (220 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20 like 2. (294 aa)
	mlh3	MutL homolog 3 (E. coli). (1117 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
	rfc1	Replication factor C subunit 1. (1167 aa)
	msh4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (914 aa)
	LOC106906886	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (638 aa)
	meiob	Methionine sulfoxide reductase B1b. (450 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	pms1	PMS1 homolog 1, mismatch repair system component. (844 aa)
	ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (171 aa)
	exo1	Exonuclease 1. (769 aa)
	fbh1	F-box DNA helicase 1. (1057 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1378 aa)
	rexo4	REX4 homolog, 3'-5' exonuclease. (409 aa)
	LOC106915420	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	msh5	MutS homolog 5. (802 aa)
	LOC106934012	ATPase family AAA domain containing 5a. (1813 aa)
	pold1	DNA polymerase. (1105 aa)
	cabp5	Calcium binding protein 5b. (169 aa)
	LOC106927947	Interferon stimulated exonuclease gene. (332 aa)
	sass6	Sas6_CC domain-containing protein. (473 aa)
	ENSPMEP00000013475	MutS_I domain-containing protein. (162 aa)
	LOC106908704	MutS homolog 3 (E. coli). (1032 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	lig1	DNA ligase. (1002 aa)
	rpa2	Replication protein A2. (278 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	atad5	AAA domain-containing protein. (825 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (826 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (282 aa)
	stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (363 aa)
	ENSPMEP00000003442	PRKR interacting protein 1. (165 aa)
	ENSPMEP00000000796	RAD17 checkpoint clamp loader component. (531 aa)
	rpa3	Replication protein A3. (122 aa)
	rfc3	Replication factor C (activator 1) 3. (376 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMEP00000000796	ISG20L2	ENSPMEP00000000796	ENSPMEP00000027731	RAD17 checkpoint clamp loader component.	Interferon stimulated exonuclease gene 20 like 2.	0.627
ENSPMEP00000000796	LOC106906255	ENSPMEP00000000796	ENSPMEP00000033612	RAD17 checkpoint clamp loader component.	RPA_C domain-containing protein.	0.768
ENSPMEP00000000796	LOC106906886	ENSPMEP00000000796	ENSPMEP00000022609	RAD17 checkpoint clamp loader component.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.892
ENSPMEP00000000796	LOC106910889	ENSPMEP00000000796	ENSPMEP00000028128	RAD17 checkpoint clamp loader component.	Rep_fac-A_C domain-containing protein.	0.892
ENSPMEP00000000796	LOC106915420	ENSPMEP00000000796	ENSPMEP00000017706	RAD17 checkpoint clamp loader component.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.892
ENSPMEP00000000796	LOC106924131	ENSPMEP00000000796	ENSPMEP00000028172	RAD17 checkpoint clamp loader component.	Exonuclease domain-containing protein.	0.627
ENSPMEP00000000796	LOC106927947	ENSPMEP00000000796	ENSPMEP00000014482	RAD17 checkpoint clamp loader component.	Interferon stimulated exonuclease gene.	0.627
ENSPMEP00000000796	LOC106934012	ENSPMEP00000000796	ENSPMEP00000016741	RAD17 checkpoint clamp loader component.	ATPase family AAA domain containing 5a.	0.936
ENSPMEP00000000796	atad5	ENSPMEP00000000796	ENSPMEP00000010424	RAD17 checkpoint clamp loader component.	AAA domain-containing protein.	0.936
ENSPMEP00000000796	exo1	ENSPMEP00000000796	ENSPMEP00000018325	RAD17 checkpoint clamp loader component.	Exonuclease 1.	0.905
ENSPMEP00000000796	lig1	ENSPMEP00000000796	ENSPMEP00000011322	RAD17 checkpoint clamp loader component.	DNA ligase.	0.880
ENSPMEP00000000796	meiob	ENSPMEP00000000796	ENSPMEP00000022277	RAD17 checkpoint clamp loader component.	Methionine sulfoxide reductase B1b.	0.874
ENSPMEP00000000796	mlh1	ENSPMEP00000000796	ENSPMEP00000017892	RAD17 checkpoint clamp loader component.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.581
ENSPMEP00000000796	mlh3	ENSPMEP00000000796	ENSPMEP00000027595	RAD17 checkpoint clamp loader component.	MutL homolog 3 (E. coli).	0.457
ENSPMEP00000000796	msh2	ENSPMEP00000000796	ENSPMEP00000026526	RAD17 checkpoint clamp loader component.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.413
ENSPMEP00000000796	msh5	ENSPMEP00000000796	ENSPMEP00000017378	RAD17 checkpoint clamp loader component.	MutS homolog 5.	0.496
ENSPMEP00000000796	pcna	ENSPMEP00000000796	ENSPMEP00000006790	RAD17 checkpoint clamp loader component.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.971
ENSPMEP00000000796	pms1	ENSPMEP00000000796	ENSPMEP00000019513	RAD17 checkpoint clamp loader component.	PMS1 homolog 1, mismatch repair system component.	0.457
ENSPMEP00000000796	pms2	ENSPMEP00000000796	ENSPMEP00000006812	RAD17 checkpoint clamp loader component.	PMS1 homolog 2, mismatch repair system component.	0.457
ENSPMEP00000000796	pold1	ENSPMEP00000000796	ENSPMEP00000016538	RAD17 checkpoint clamp loader component.	DNA polymerase.	0.813