(106 nodes) Adipocytokine signaling pathway network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106920965	AMP-binding domain-containing protein. (746 aa)
	LOC106922448	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
	ENSPMEP00000000479	Agouti domain-containing protein. (147 aa)
	LOC106921111	Adiponectin receptor 2. (368 aa)
	LOC106932994	Protein tyrosine phosphatase non-receptor type 11b. (584 aa)
	LOC106906110	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (783 aa)
	nostrin	Nitric oxide synthase trafficking. (576 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	LOC106931038	Acyl-CoA synthetase long chain family member 1b. (698 aa)
	LOC106933633	Non-specific serine/threonine protein kinase. (508 aa)
	LOC106907458	V-rel avian reticuloendotheliosis viral oncogene homolog A. (628 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	LOC106930974	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (392 aa)
	cpt1b	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (787 aa)
	LOC106915153	Protein kinase domain-containing protein. (670 aa)
	LOC106921698	Si:ch211-112c15.8. (393 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC106919797	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (544 aa)
	LOC106915127	Mitogen-activated protein kinase. (461 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	prkag3	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (353 aa)
	LOC106927524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC106903255	Neuropeptide Y. (104 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (665 aa)
	camkk2	Si:ch73-62l21.1. (572 aa)
	slc2a2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (503 aa)
	LOC106920878	Mitogen-activated protein kinase. (420 aa)
	LOC106927467	Suppressor of cytokine signaling 3. (208 aa)
	LOC106914978	Acyl-CoA synthetase long chain family member 2. (699 aa)
	prkab1	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	irs2	Insulin receptor substrate 2b. (1112 aa)
	LOC106927357	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	LOC106906561	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
	ENSPMEP00000010696	RHD domain-containing protein. (69 aa)
	LOC106918889	Uncharacterized protein. (156 aa)
	LOC106932734	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (788 aa)
	LOC106929967	Acyl-CoA synthetase bubblegum family member 2. (795 aa)
	LOC106905501	Uncharacterized protein. (236 aa)
	LOC106928665	Fibronectin type-III domain-containing protein. (827 aa)
	LOC106929945	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (298 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (686 aa)
	stat3	Signal transducer and activator of transcription. (787 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (524 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (267 aa)
	LOC106929252	Insulin receptor substrate 4a. (1363 aa)
	LOC106926646	leptin-B-like. (156 aa)
	LOC106920592	Agouti signaling protein, nonagouti homolog (mouse) 2b. (115 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (567 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
	mapk10	Mitogen-activated protein kinase. (422 aa)
	acacb	Acetyl-CoA carboxylase beta. (2221 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (334 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (763 aa)
	LOC106906991	Insulin receptor substrate 2a. (1062 aa)
	LOC106919916	Uncharacterized protein. (207 aa)
	tradd	Tnfrsf1a-associated via death domain. (292 aa)
	LOC106904791	Si:ch211-284e13.4. (1164 aa)
	lepr	Uncharacterized protein. (653 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1274 aa)
	LOC106916563	Solute carrier family 2 member 3b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (490 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	NPY	Neuropeptide Y. (92 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (565 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
	adipor1	Adiponectin receptor 1a. (376 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (564 aa)
	mapk8	Mitogen-activated protein kinase. (426 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (365 aa)
	REL	REL proto-oncogene, NF-kB subunit. (641 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)
	LOC106904394	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (307 aa)
	LOC106917048	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (599 aa)
	LOC106932106	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC106919755	Solute carrier family 2 member 3a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (530 aa)
	LOC106918249	Solute carrier family 2 member 1b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
	LOC106931456	Acyl-CoA synthetase long chain family member 3b. (710 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (472 aa)
	RXRB	Uncharacterized protein. (469 aa)
	LOC106928697	Retinoid X receptor, alpha a. (422 aa)
	LOC106916811	Uncharacterized protein. (453 aa)
	g6pc3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (339 aa)
	LOC106909565	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (635 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (555 aa)
	LOC106933334	Serine/threonine-protein kinase STK11-like. (439 aa)
	jak2	Tyrosine-protein kinase. (1124 aa)
	LOC106908735	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (247 aa)
	ENSPMEP00000029638	Suppressor of cytokine signaling 3a. (199 aa)
	LOC106926090	Tumor necrosis factor receptor superfamily, member 1B. (440 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (379 aa)
	LOC106934130	Si:ch73-335l21.1. (1323 aa)
	mtor	Serine/threonine-protein kinase TOR. (1745 aa)
	LOC106922682	AMP-binding domain-containing protein. (699 aa)
	acsl3	Uncharacterized protein. (718 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1a. (718 aa)
	STAT3	Signal transducer and activator of transcription 3. (739 aa)
	LOC106930528	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (629 aa)
	LOC106903438	Retinoid x receptor, beta b. (444 aa)
	LOC106926582	Solute carrier family 2 member 1a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (497 aa)
	LOC106933899	Glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1. (362 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (490 aa)
	LOC106911661	Uncharacterized protein. (690 aa)
	JAK2	Tyrosine-protein kinase. (1123 aa)
	LOC106911580	Agouti domain-containing protein. (141 aa)
	LOC106924457	Proopiomelanocortin. (185 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPMEP00000010696	ENSPMEP00000018252	ENSPMEP00000010696	Component of inhibitor of nuclear factor kappa B kinase complex.	RHD domain-containing protein.	0.953
CHUK	JAK2	ENSPMEP00000018252	ENSPMEP00000033917	Component of inhibitor of nuclear factor kappa B kinase complex.	Tyrosine-protein kinase.	0.469
CHUK	LOC106904394	ENSPMEP00000018252	ENSPMEP00000024133	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.959
CHUK	LOC106904791	ENSPMEP00000018252	ENSPMEP00000019751	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:ch211-284e13.4.	0.922
CHUK	LOC106906991	ENSPMEP00000018252	ENSPMEP00000018435	Component of inhibitor of nuclear factor kappa B kinase complex.	Insulin receptor substrate 2a.	0.939
CHUK	LOC106907458	ENSPMEP00000018252	ENSPMEP00000003079	Component of inhibitor of nuclear factor kappa B kinase complex.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.783
CHUK	LOC106915153	ENSPMEP00000018252	ENSPMEP00000003858	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.925
CHUK	LOC106917048	ENSPMEP00000018252	ENSPMEP00000024629	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.718
CHUK	LOC106921698	ENSPMEP00000018252	ENSPMEP00000003954	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:ch211-112c15.8.	0.760
CHUK	LOC106927524	ENSPMEP00000018252	ENSPMEP00000006139	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.949
CHUK	LOC106929252	ENSPMEP00000018252	ENSPMEP00000015524	Component of inhibitor of nuclear factor kappa B kinase complex.	Insulin receptor substrate 4a.	0.968
CHUK	LOC106929945	ENSPMEP00000018252	ENSPMEP00000013254	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.778
CHUK	LOC106930528	ENSPMEP00000018252	ENSPMEP00000032556	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.718
CHUK	LOC106932106	ENSPMEP00000018252	ENSPMEP00000025411	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.949
CHUK	LOC106932994	ENSPMEP00000018252	ENSPMEP00000001892	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein tyrosine phosphatase non-receptor type 11b.	0.414
CHUK	LOC106933633	ENSPMEP00000018252	ENSPMEP00000002682	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase.	0.949
CHUK	LOC106934130	ENSPMEP00000018252	ENSPMEP00000030322	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:ch73-335l21.1.	0.939
CHUK	REL	ENSPMEP00000018252	ENSPMEP00000022809	Component of inhibitor of nuclear factor kappa B kinase complex.	REL proto-oncogene, NF-kB subunit.	0.783
CHUK	STAT3	ENSPMEP00000018252	ENSPMEP00000032508	Component of inhibitor of nuclear factor kappa B kinase complex.	Signal transducer and activator of transcription 3.	0.583
CHUK	akt1	ENSPMEP00000018252	ENSPMEP00000004345	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.949