STRINGSTRING
secE secE rpoB rpoB rpoC rpoC tufA tufA secY secY rpoA rpoA Aflv_0174 Aflv_0174 Aflv_0222 Aflv_0222 Aflv_0319 Aflv_0319 Aflv_0323 Aflv_0323 oppA oppA appB appB appC appC Aflv_0368 Aflv_0368 Aflv_0433 Aflv_0433 Aflv_0452 Aflv_0452 tpx tpx Aflv_0488 Aflv_0488 msrA msrA trxA trxA secF secF sodA sodA pstS pstS bkdB bkdB ribD ribD Aflv_1025 Aflv_1025 sodF sodF resA resA Aflv_1069 Aflv_1069 ndk ndk gutB gutB katG katG Aflv_1262 Aflv_1262 Aflv_1294 Aflv_1294 Aflv_1319 Aflv_1319 Aflv_1326 Aflv_1326 Aflv_1327 Aflv_1327 Aflv_1328 Aflv_1328 Aflv_1368 Aflv_1368 Aflv_1401 Aflv_1401 arsC arsC mdr mdr Aflv_1617 Aflv_1617 rpoZ rpoZ pdhC pdhC Aflv_2032 Aflv_2032 blt blt Aflv_2080 Aflv_2080 Aflv_2106 Aflv_2106 Aflv_2119 Aflv_2119 oppC oppC oppB oppB Aflv_2325 Aflv_2325 bdbA bdbA alaR alaR Aflv_2392 Aflv_2392 Aflv_2403 Aflv_2403 Aflv_2445 Aflv_2445 secG secG trxB trxB secA secA secA-2 secA-2 Aflv_2717 Aflv_2717 ahpC ahpC Aflv_2776 Aflv_2776
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (60 aa)
rpoBDNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1189 aa)
rpoCDNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa)
tufATranslation elongation factor Tu, EF-Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (430 aa)
rpoADNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa)
Aflv_0174Thioredoxin reductase. (351 aa)
Aflv_0222Permease of the major facilitator superfamily, mdtH subfamily. (405 aa)
Aflv_0319Protein phosphatase, low molecular weight phosphatase family. (156 aa)
Aflv_0323Permease of the major facilitator superfamily. (390 aa)
oppAABC-type dipeptide transport system, periplasmic component. (534 aa)
appBABC-type dipeptide/oligopeptide/nickel transport system, permease component. (354 aa)
appCABC-type dipeptide/oligopeptide/nickel transport system, permease component. (297 aa)
Aflv_0368Peroxiredoxin. (153 aa)
Aflv_0433Maltose permease, MFS type. (383 aa)
Aflv_0452Thioredoxin. (111 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (168 aa)
Aflv_0488Metal-dependent hydrolase; Belongs to the UPF0173 family. (225 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (186 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (104 aa)
secFPreprotein translocase subunits SecDF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (748 aa)
sodASuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (202 aa)
pstSABC-type phosphate transport system, periplasmic component. (348 aa)
bkdBBranched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). (432 aa)
ribDRiboflavin-specific pyrimidine reductase/deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (358 aa)
Aflv_1025Permease of the major facilitator superfamily. (400 aa)
sodFSuperoxide dismutase. (274 aa)
resAThiol-disulfide oxidoreductase resA (cytochrome c biogenesis). (175 aa)
Aflv_1069Thioredoxin reductase. (365 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa)
gutBZn-dependent alcohol dehydrogenase. (385 aa)
katGCatalase (peroxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (761 aa)
Aflv_1262Permease of the major facilitator superfamily. (409 aa)
Aflv_1294Permease of the major facilitator superfamily. (420 aa)
Aflv_1319Predicted protein. (179 aa)
Aflv_1326ABC-type multidrug transport system, ATPase and permease component. (584 aa)
Aflv_1327ABC-type multidrug transport system, ATPase and permease component. (609 aa)
Aflv_1328Predicted Zn-dependent hydrolase of the beta-lactamase fold. (308 aa)
Aflv_1368Thiol:disulfide interchange protein (thioredoxin). (180 aa)
Aflv_1401Thioredoxin. (206 aa)
arsCProtein phosphatase, low molecular weight phosphatase family; Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. (138 aa)
mdrMultidrug-efflux transporter; Belongs to the major facilitator superfamily. (523 aa)
Aflv_1617Membrane-associated thiol-disulfide oxidoreductase. (333 aa)
rpoZDNA-directed RNA polymerase, subunit K/omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (72 aa)
pdhCPyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (434 aa)
Aflv_2032Ferritin; Iron-storage protein. (175 aa)
bltPermease of the major facilitator superfamily. (388 aa)
Aflv_2080Thioredoxin. (105 aa)
Aflv_2106Permease of the major facilitator superfamily. (416 aa)
Aflv_2119Hemoglobin-like protein. (134 aa)
oppCABC-type oligopeptide transport system, permease component. (336 aa)
oppBABC-type oligopeptide transport system, permease component. (312 aa)
Aflv_2325Permease of the major facilitator superfamily. (538 aa)
bdbAThiol-disulfide isomerase. (154 aa)
alaRTranscriptional regulator (Lrp/AsnC family). (167 aa)
Aflv_2392Cu/Zn superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (170 aa)
Aflv_2403Thioredoxin reductase. (341 aa)
Aflv_2445Permease of the major facilitator superfamily. (417 aa)
secGPreprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (82 aa)
trxBThioredoxin reductase. (327 aa)
secAPreprotein translocase subunit SecA (ATPase, RNA helicase); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (856 aa)
secA-2Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (798 aa)
Aflv_2717Protein phosphatase, low molecular weight phosphatase family. (145 aa)
ahpCAlkyl hydroperoxide reductase small subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
Aflv_2776Permease of the major facilitator superfamily. (398 aa)
Your Current Organism:
Anoxybacillus flavithermus
NCBI taxonomy Id: 491915
Other names: A. flavithermus WK1, Anoxybacillus flavithermus WK1, Anoxybacillus flavithermus str. WK1, Anoxybacillus flavithermus strain WK1
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