| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aflv_0486 | birA | Aflv_0486 | Aflv_1125 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | Biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.431 |
| Aflv_0486 | fabZ | Aflv_0486 | Aflv_2678 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.935 |
| Aflv_1164 | bioA | Aflv_1164 | Aflv_1071 | Carboxylesterase bioH (Biotin synthesis protein bioH). | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.574 |
| Aflv_1164 | bioC | Aflv_1164 | Aflv_1165 | Carboxylesterase bioH (Biotin synthesis protein bioH). | SAM-dependent methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.937 |
| Aflv_1164 | bioD | Aflv_1164 | Aflv_1070 | Carboxylesterase bioH (Biotin synthesis protein bioH). | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.812 |
| Aflv_1164 | birA | Aflv_1164 | Aflv_1125 | Carboxylesterase bioH (Biotin synthesis protein bioH). | Biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.421 |
| Aflv_1164 | fabI | Aflv_1164 | Aflv_2107 | Carboxylesterase bioH (Biotin synthesis protein bioH). | Enoyl-[acyl-carrier-protein] reductase (NADH). | 0.908 |
| Aflv_1164 | kbl | Aflv_1164 | Aflv_1163 | Carboxylesterase bioH (Biotin synthesis protein bioH). | 7-keto-8-aminopelargonate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.990 |
| Aflv_1265 | birA | Aflv_1265 | Aflv_1125 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | Biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.431 |
| Aflv_1265 | fabZ | Aflv_1265 | Aflv_2678 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.934 |
| Aflv_1536 | birA | Aflv_1536 | Aflv_1125 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | Biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.431 |
| Aflv_1536 | fabZ | Aflv_1536 | Aflv_2678 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.934 |
| Aflv_1536 | kbl | Aflv_1536 | Aflv_1163 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. | 7-keto-8-aminopelargonate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.403 |
| bioA | Aflv_1164 | Aflv_1071 | Aflv_1164 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Carboxylesterase bioH (Biotin synthesis protein bioH). | 0.574 |
| bioA | bioB | Aflv_1071 | Aflv_1376 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.969 |
| bioA | bioC | Aflv_1071 | Aflv_1165 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | SAM-dependent methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.592 |
| bioA | bioD | Aflv_1071 | Aflv_1070 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
| bioA | birA | Aflv_1071 | Aflv_1125 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.586 |
| bioA | kbl | Aflv_1071 | Aflv_1163 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 7-keto-8-aminopelargonate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.990 |
| bioB | bioA | Aflv_1376 | Aflv_1071 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.969 |