Your Input: | |
| | guaB | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (291 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | hprT | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (188 aa) |
| | cysK | Cysteine synthetase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | ispD | 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (240 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | cysE | Serine acetyltransferase. (230 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | rocF | Arginase; Belongs to the arginase family. (298 aa) |
| | Aflv_0158 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (203 aa) |
| | Aflv_0181 | Biotin carboxylase. (470 aa) |
| | Aflv_0182 | Biotin carboxyl carrier protein. (70 aa) |
| | Aflv_0183 | Hydroxymethylglutaryl-CoA lyase. (296 aa) |
| | argJ | N-acetylglutamate synthase (N-acetylornithine aminotransferase); Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (399 aa) |
| | Aflv_0220 | Carboxyethyl arginine synthase (C-terminal TPP binding domain). (326 aa) |
| | Aflv_0223 | Acetyltransferase (GNAT family); Belongs to the acetyltransferase family. (151 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (382 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (439 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (240 aa) |
| | purS | Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and i [...] (84 aa) |
| | purQ | Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with [...] (228 aa) |
| | purL | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] (740 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (494 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (200 aa) |
| | purH | Inosine-monophosphate cyclohydrolase. (511 aa) |
| | purD | Phosphoribosylglycinamide synthetase; Belongs to the GARS family. (426 aa) |
| | Aflv_0271 | NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (449 aa) |
| | Aflv_0288 | Diacylglycerol kinase family enzyme. (311 aa) |
| | Aflv_0298 | Nitric oxide synthase, oxygenase domain; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (353 aa) |
| | Aflv_0310 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). (165 aa) |
| | Aflv_0311 | Sirohydrochlorin ferrochelatase. (235 aa) |
| | Aflv_0312 | Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. (260 aa) |
| | sat | ATP sulfurylase (sulfate adenylyltransferase); Belongs to the sulfate adenylyltransferase family. (358 aa) |
| | Aflv_0328 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (500 aa) |
| | adhA | Zn-dependent alcohol dehydrogenase. (353 aa) |
| | gltA-2 | Glutamate synthase large subunit. (1490 aa) |
| | gsaB | Glutamate-1-semialdehyde aminotransferase. (455 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (648 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (407 aa) |
| | glgD | ADP-glucose pyrophosphorylase. (340 aa) |
| | glgA | Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (484 aa) |
| | glgP | Glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (798 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (311 aa) |
| | menF | Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (451 aa) |
| | menD | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (581 aa) |
| | menH-2 | Alpha/beta superfamily hydrolase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (275 aa) |
| | menB | Dihydroxynaphthoic acid synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (272 aa) |
| | menE | O-succinylbenzoic acid-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. (488 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (556 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (401 aa) |
| | Aflv_0438 | Type II secretory pathway, pullulanase; Belongs to the glycosyl hydrolase 13 family. (706 aa) |
| | aroA | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (363 aa) |
| | acsA | Acyl-coenzyme A synthetase. (573 aa) |
| | hisJ | Histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (273 aa) |
| | Aflv_0474 | Acetyl-coenzyme A synthetase. (565 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argH | Argininosuccinate lyase. (458 aa) |
| | Aflv_0486 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. (253 aa) |
| | accD | Acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | accA | Acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | Aflv_0500 | Pyruvate kinase fused to PEP-utilizers swivelling domain. (599 aa) |
| | citZ | Citrate synthase; Belongs to the citrate synthase family. (372 aa) |
| | icd | Isocitrate dehydrogenase. (429 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (342 aa) |
| | galM | Aldose 1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer. (366 aa) |
| | sdhC | Succinate dehydrogenase, cytochrome b subunit. (202 aa) |
| | sdhA | Succinate dehydrogenase, flavoprotein subunit. (586 aa) |
| | sdhB | Succinate dehydrogenase, Fe-S protein subunit. (253 aa) |
| | dat | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (300 aa) |
| | ilvB | Acetolactate synthase large subunit. (602 aa) |
| | ilvH | Acetolactate synthase small subunit. (173 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | leuB | Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (369 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (444 aa) |
| | hemC | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (249 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. (324 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase. (438 aa) |
| | pheB | ACT domain-containing protein PheB; Belongs to the UPF0735 family. (159 aa) |
| | pheA | Prephenate dehydratase. (287 aa) |
| | Aflv_0761 | Cystathionine gamma-synthase(O-succinylhomoserine (thiol)-lyase). (377 aa) |
| | pssA | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (265 aa) |
| | aroD | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (299 aa) |
| | ispH | 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (364 aa) |
| | Aflv_0886 | Nucleoside-diphosphate-sugar pyrophosphorylase fused to phosphomannomutase. (815 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (325 aa) |
| | glcK | Transcriptional regulator/glucose kinase. (321 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa) |
| | gcvT | Glycine cleavage system protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | gcvPA | Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa) |
| | gcvPB | Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (484 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | accB | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | Aflv_0947 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (290 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | bcd | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa) |
| | lpdV | Branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). (474 aa) |
| | bkdAA | Branched-chain alpha-keto acid dehydrogenase E1 subunit (2-oxoisovalerate dehydrogenase alpha subunit). (330 aa) |
| | bkdAB | Branched-chain alpha-keto acid dehydrogenase E1 subunit (2-oxoisovalerate dehydrogenase beta subunit). (327 aa) |
| | bkdB | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). (432 aa) |
| | Aflv_0971 | Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (516 aa) |
| | Aflv_0976 | 6-phosphogluconate dehydrogenase; Belongs to the 6-phosphogluconate dehydrogenase family. (456 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa) |
| | proI | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | punA | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa) |
| | ribD | Riboflavin-specific pyrimidine reductase/deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (358 aa) |
| | ribE | Riboflavin synthase alpha chain. (215 aa) |
| | ribA | 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribH | Riboflavin synthase beta-chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (154 aa) |
| | Aflv_1024 | Threonine aldolase. (353 aa) |
| | hisJ-2 | Histidinol phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (270 aa) |
| | serA | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (549 aa) |
| | Aflv_1078 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (203 aa) |
| | fni | Isopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (354 aa) |
| | gpsA | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | Aflv_1093 | Heptaprenyl diphosphate synthase component I. (215 aa) |
| | menH | Methylase involved in ubiquinone/menaquinone biosynthesis; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (237 aa) |
| | hepT | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (320 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (425 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (412 aa) |
| | aroH | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (144 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (519 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (253 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (211 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (371 aa) |
| | tyrA | Prephenate dehydrogenase. (367 aa) |
| | aroE | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (295 aa) |
| | panC | Panthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | aspB | Aspartate aminotransferase. (395 aa) |
| | glpD | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (555 aa) |
| | Aflv_1157 | Glycerate kinase; Belongs to the glycerate kinase type-1 family. (373 aa) |
| | dhaS | NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa) |
| | gutB | Zn-dependent alcohol dehydrogenase. (385 aa) |
| | katG | Catalase (peroxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (761 aa) |
| | Aflv_1204 | Radical SAM superfamily enzyme. (380 aa) |
| | sacA | Sucrase-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (496 aa) |
| | asnB | Asparagine synthetase. (630 aa) |
| | gltA | Glutamate synthase (large subunit). (1514 aa) |
| | gltB | Glutamate synthase (small subunit). (486 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (570 aa) |
| | ilvB-2 | Acetolactate synthase (acetohydroxy-acid synthase) (large subunit); Belongs to the TPP enzyme family. (541 aa) |
| | Aflv_1247 | Saccharopine dehydrogenase (NADP+, L-glutamate-forming). (430 aa) |
| | Aflv_1265 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. (258 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (413 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (378 aa) |
| | Aflv_1281 | Acyl-CoA dehydrogenase. (556 aa) |
| | menC | O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (380 aa) |
| | deoD | Purine-nucleoside phosphorylase. (234 aa) |
| | ilvA | Threonine dehydratase. (402 aa) |
| | plsY | Predicted membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa) |
| | ilvA-2 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | Aflv_1473 | Uroporphyrinogen-III synthase. (296 aa) |
| | citB | Aconitase A; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (902 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (678 aa) |
| | Aflv_1512 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | mmgC | Acyl-CoA dehydrogenase. (380 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (311 aa) |
| | Aflv_1524 | 2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (295 aa) |
| | Aflv_1525 | 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (578 aa) |
| | Aflv_1536 | Dehydrogenase; Related to short-chain alcohol dehydrogenases. (237 aa) |
| | Aflv_1539 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (728 aa) |
| | dhaS-2 | NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa) |
| | mqo | Malate/quinone oxidoreductase. (518 aa) |
| | Aflv_1671 | Proline dehydrogenase. (310 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | dapG | Aspartokinase I (alpha and beta subunits); Belongs to the aspartokinase family. (412 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | ribC | FAD synthase; Belongs to the ribF family. (326 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | cdsA | Phosphatidate cytidylyltransferase (CDP-diglyceride synthase); Belongs to the CDS family. (255 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (254 aa) |
| | sucD | Succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | sucC | Succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (401 aa) |
| | acpA | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | fabD | (acyl-carrier-protein) S-malonyltransferase. (314 aa) |
| | plsX | Fatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (329 aa) |
| | sdaAA | L-serine dehydratase (alpha chain); Belongs to the iron-sulfur dependent L-serine dehydratase family. (295 aa) |
| | sdaAB | L-serine dehydratase (beta chain); Belongs to the iron-sulfur dependent L-serine dehydratase family. (245 aa) |
| | rpe | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa) |
| | Aflv_1841 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (297 aa) |
| | ctaB | Heme O synthase (polyprenyltransferase); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (301 aa) |
| | ctaA | Heme A synthase (monooxygenase); Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (316 aa) |
| | Aflv_1882 | Inositol-1-monophosphatase (IMPase). (260 aa) |
| | pdhD | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (470 aa) |
| | pdhC | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (434 aa) |
| | pdhB | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (325 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa) |
| | Aflv_1903 | Metal-dependent amidase/aminoacylase/carboxypeptidase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (391 aa) |
| | dapH | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (235 aa) |
| | patA | Aspartate/tyrosine/aromatic aminotransferase. (383 aa) |
| | fabG-2 | 3-oxoacyl-[acyl-carrier-protein] protein reductase. (255 aa) |
| | Aflv_2016 | Radical SAM superfamily enzyme. (588 aa) |
| | Aflv_2029 | Glycolate oxidase, subunit GlcD. (470 aa) |
| | Aflv_2030 | Glycolate oxidase, iron-sulfur subunit GlcF. (447 aa) |
| | Aflv_2043 | Predicted amino acid racemase. (366 aa) |
| | ansA | L-asparaginase. (339 aa) |
| | Aflv_2066 | Cystathionine beta-lyase. (379 aa) |
| | Aflv_2067 | Cystathionine gamma-synthase(O-succinylhomoserine (thiol)-lyase). (367 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase (NADH). (258 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (314 aa) |
| | argD | Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (252 aa) |
| | argJ-2 | N-acetylglutamate synthase (N-acetylornithine aminotransferase); Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argC | Acetylglutamate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | Aflv_2156 | Predicted hydrolase of the HAD superfamily. (268 aa) |
| | Aflv_2165 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. (617 aa) |
| | Aflv_2166 | Methionine synthase I containing methyltransferase and cobalamin-binding domains; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1142 aa) |
| | Aflv_2168 | Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. (274 aa) |
| | Aflv_2187 | Alpha-glucosidase, family 31 of glycosyl hydrolase; Belongs to the glycosyl hydrolase 31 family. (782 aa) |
| | Aflv_2188 | Alpha-amylase domain. (505 aa) |
| | Aflv_2192 | Cyclomaltodextrinase; Belongs to the glycosyl hydrolase 13 family. (587 aa) |
| | Aflv_2199 | Phytoene/squalene synthetase. (285 aa) |
| | Aflv_2200 | Phytoene dehydrogenase (Phytoene desaturase). (473 aa) |
| | Aflv_2201 | Phytoene dehydrogenase (Phytoene desaturase). (513 aa) |
| | asnO | Asparagine synthase (glutamine-hydrolyzing). (629 aa) |
| | rocD | Ornithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (413 aa) |
| | Aflv_2241 | Isocitrate lyase. (426 aa) |
| | Aflv_2242 | Zn-dependent protease with chaperone function. (415 aa) |
| | hemY | Protoporphyrinogen IX and coproporphyrinogen III oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (472 aa) |
| | hemH | Protoheme ferro-lyase (ferrochelatase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (315 aa) |
| | hemE | Uroporphyrinogen-III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (349 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (358 aa) |
| | hemZ | Coproporphyrinogen III oxidase hemZ. (499 aa) |
| | Aflv_2324 | Glycosidase. (554 aa) |
| | Aflv_2333 | Phosphomannomutase. (588 aa) |
| | Aflv_2360 | Beta-glucosidase. (461 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (474 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | hom | Homoserine dehydrogenase. (451 aa) |
| | Aflv_2415 | 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | Aflv_2431 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (474 aa) |
| | gcvH | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (127 aa) |
| | Aflv_2481 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | Aflv_2486 | Proline dehydrogenase. (323 aa) |
| | Aflv_2491 | Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides. (103 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | pgm | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (511 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase/pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (207 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase. (242 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (425 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (213 aa) |
| | hisZ | ATP phosphoribosyltransferase involved in histidine biosynthesis; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (394 aa) |
| | Aflv_2607 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. (640 aa) |
| | Aflv_2648 | Aspartokinase; Belongs to the aspartokinase family. (448 aa) |
| | gtaB | UTP-glucose-1-phosphate uridylyltransferase. (323 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | rpiB | Ribose 5-phosphate isomerase. (173 aa) |
| | glpX | Fructose-1,6-bisphosphatase (Class II). (346 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (224 aa) |
| | fbaA | Fructose-1,6-bisphosphate aldolase. (295 aa) |
| | acdA-2 | Acyl-CoA dehydrogenase. (379 aa) |
| | mmgA | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa) |
| | Aflv_2762 | Predicted heme peroxidase involved in anaerobic stress response; May function as heme-dependent peroxidase. (251 aa) |
| | sacA-2 | Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (482 aa) |
| | sacK | Fructokinase (ribokinase family); Belongs to the carbohydrate kinase PfkB family. (321 aa) |
| | Aflv_2814 | NAD-dependent aldehyde dehydrogenase domain and Fe-dependent alcohol dehydrogense domain; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (880 aa) |
