(44 nodes) Mixed, incl. Prosthetic group metabolic process, and Inorganic anion transport network (Neisseria canis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	moaA	Cyclic pyranopterin phosphate synthase MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (324 aa)
	potF_1	Hypothetical protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (391 aa)
	narG	Nitrate reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1225 aa)
	modE	Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
	moeZ	Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
	mog	Molybdopterin adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
	potF_2	Polyamine ABC transporter substrate-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (380 aa)
	OSI13037.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
	sbp	Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
	cysA	Sulfate ABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (360 aa)
	cysW	Sulfate ABC transporter permease subunit CysW; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
	cysU_1	Sulfate ABC transporter permease subunit CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (275 aa)
	fbpC_4	Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	cysU_2	Molybdenum ABC transporter permease subunit; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (224 aa)
	modA	Molybdate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
	narI	Respiratory nitrate reductase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	narJ	Nitrate reductase molybdenum cofactor assembly chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
	narY	Nitrate reductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa)
	fbpC_3	Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (342 aa)
	fbpB	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
	OSI12505.1	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	ycbX_2	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
	potA	Polyamine ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (372 aa)
	potH	Putrescine/spermidine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
	ydcV	Polyamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
	moeA	Molybdopterin molybdenumtransferase MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (398 aa)
	mobA	Hypothetical protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (193 aa)
	moaE	Molybdenum cofactor biosynthesis protein MoaE; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
	OSI11838.1	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
	dtd	D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (153 aa)
	thiF	Molybdopterin-synthase adenylyltransferase MoeB; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
	moaC	Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (167 aa)
	cysJ	Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (591 aa)
	cysN	Sulfate adenylyltransferase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (436 aa)
	cysI	Sulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (588 aa)
	cysD	Sulfate adenylyltransferase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
	cysH	Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (243 aa)
	yadH	Metal-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
	ybhF_2	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
	potD-1	Polyamine ABC transporter substrate-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (380 aa)
	OSI10338.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (126 aa)
	narT	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
	narK	Nitrate/nitrite transporter; Involved in the transport of nitrate and nitrite; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
	OSI10342.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)

Your Current Organism:

Neisseria canis

NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OSI10338.1	narT	BWD07_10660	BWD07_10665	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.416
OSI11838.1	moaA	BWD07_08590	BWD07_00765	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cyclic pyranopterin phosphate synthase MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.857
OSI11838.1	moaC	BWD07_08590	BWD07_08860	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.	0.933
OSI11838.1	moaE	BWD07_08590	BWD07_08585	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdenum cofactor biosynthesis protein MoaE; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OSI11838.1	mobA	BWD07_08590	BWD07_08580	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family.	0.906
OSI11838.1	modA	BWD07_08590	BWD07_04575	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.417
OSI11838.1	moeA	BWD07_08590	BWD07_08575	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdopterin molybdenumtransferase MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.962
OSI11838.1	mog	BWD07_08590	BWD07_02080	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdopterin adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.779
OSI11838.1	narG	BWD07_08590	BWD07_01650	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrate reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.417
OSI11838.1	narY	BWD07_08590	BWD07_04640	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrate reductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
OSI11838.1	thiF	BWD07_08590	BWD07_08855	Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molybdopterin-synthase adenylyltransferase MoeB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.874
OSI12505.1	cysU_1	BWD07_05220	BWD07_03100	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfate ABC transporter permease subunit CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	0.468
OSI12505.1	fbpB	BWD07_05220	BWD07_05215	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
OSI12505.1	fbpC_3	BWD07_05220	BWD07_05210	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.987
OSI12505.1	fbpC_4	BWD07_05220	BWD07_04565	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
OSI12505.1	potA	BWD07_05220	BWD07_08560	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Polyamine ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.	0.562
OSI12505.1	potH	BWD07_05220	BWD07_08565	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Putrescine/spermidine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
OSI12505.1	sbp	BWD07_05220	BWD07_03085	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
OSI12505.1	ydcV	BWD07_05220	BWD07_08570	Fe(3+) ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Polyamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
OSI13037.1	ybhF_2	BWD07_02950	BWD07_09320	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468