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znuC znuC radA radA clpV1_1 clpV1_1 lolD lolD clpA clpA lon lon cysA cysA rho rho ruvB ruvB fbpC_2 fbpC_2 yjjK yjjK ftsH ftsH clpX clpX macB macB OSI13387.1 OSI13387.1 lptB lptB apxIB_2 apxIB_2 engA engA tcyC tcyC pilT_1 pilT_1 clpV1_2 clpV1_2 ctrD ctrD uvrA uvrA fbpC_1 fbpC_1 yddA yddA ybhF_1 ybhF_1 yheS_1 yheS_1 gsiA gsiA ftsE ftsE OSI12683.1 OSI12683.1 rarA rarA fbpC_4 fbpC_4 dnaX dnaX fbpC_3 fbpC_3 apxIB_1 apxIB_1 clpB clpB thiQ thiQ msbA msbA metN_2 metN_2 dnaB dnaB recA recA yusV yusV dnaA dnaA hrpA hrpA OSI12103.1 OSI12103.1 yheS_2 yheS_2 atpD atpD zraR_1 zraR_1 potA potA hmuV hmuV glnQ glnQ ybhF_2 ybhF_2 OSI11675.1 OSI11675.1 zraR_2 zraR_2 rbsA rbsA OSI11046.1 OSI11046.1 comM comM recD recD metN_1 metN_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
znuCABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (461 aa)
clpV1_1ClpV1 family T6SS ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (882 aa)
lolDLipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (226 aa)
clpAATP-dependent Clp protease ATP-binding subunit ClpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (759 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (817 aa)
cysASulfate ABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (360 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
ruvBHolliday junction branch migration DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (343 aa)
fbpC_2ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
yjjKEnergy-dependent translational throttle protein EttA; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (666 aa)
clpXATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (425 aa)
macBMacrolide ABC transporter permease/ATP-binding protein MacB; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (646 aa)
OSI13387.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
lptBLPS export ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
apxIB_2Type I secretion system permease/ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
engARibosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (486 aa)
tcyCPolar amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
pilT_1Twitching motility protein PilT; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
clpV1_2IS1595 family transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (942 aa)
ctrDATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (948 aa)
fbpC_1Proline/glycine betaine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
yddAABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
ybhF_1ABC transporter ATP-binding protein/permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (1043 aa)
yheS_1ABC-F family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
gsiAMicrocin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (513 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (216 aa)
OSI12683.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
rarAAAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
fbpC_4Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (681 aa)
fbpC_3Fe3+/spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (342 aa)
apxIB_1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (697 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
thiQABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
msbALipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (616 aa)
metN_2ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (469 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
yusVIron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
dnaAChromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (507 aa)
hrpAATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
OSI12103.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
yheS_2ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (465 aa)
zraR_1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
potAPolyamine ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (372 aa)
hmuVFerrichrome ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
glnQPolar amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
ybhF_2ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
OSI11675.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
zraR_2Sigma-54-dependent Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
rbsAD-xylose ABC transporter ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (497 aa)
OSI11046.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (620 aa)
comMATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
recDExodeoxyribonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (576 aa)
metN_1ABC transporter; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (246 aa)
Your Current Organism:
Neisseria canis
NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6
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