STRINGSTRING
ackA_2 ackA_2 glcB glcB dld dld aldA_3 aldA_3 OSI10558.1 OSI10558.1 OSI06688.1 OSI06688.1 OSI06658.1 OSI06658.1 OSI06638.1 OSI06638.1 efeB efeB efeU efeU accD accD pdhD pdhD OSI13399.1 OSI13399.1 OSI13407.1 OSI13407.1 ldhA ldhA fumA fumA leuA leuA accB accB accC accC golB golB yfeX yfeX aceE aceE aceF aceF lpdA lpdA lldD lldD ppsA ppsA ppc ppc OSI12392.1 OSI12392.1 gloA gloA OSI12177.1 OSI12177.1 ackA_1 ackA_1 accA accA OSI12137.1 OSI12137.1 maeB maeB scpC scpC pta pta pcaF pcaF aldA_1 aldA_1 pykA pykA bphJ bphJ mdh mdh lpd lpd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ackA_2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (715 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (562 aa)
aldA_3Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (494 aa)
OSI10558.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
OSI06688.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (55 aa)
OSI06658.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
OSI06638.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
efeBPeroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (423 aa)
efeUIron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
pdhDDihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
OSI13399.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
OSI13407.1Bleomycin resistance family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
ldhAL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
fumAFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (593 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
golBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (248 aa)
yfeXPeroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
aceEPyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (890 aa)
aceFDihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (545 aa)
lpdADihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa)
lldDAlpha-hydroxy-acid oxidizing enzyme; Flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (795 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (900 aa)
OSI12392.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
gloALactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (136 aa)
OSI12177.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
ackA_1Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (417 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
OSI12137.1Membrane protein FxsA; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
maeBNADP-dependent malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
scpCpropionyl-CoA--succinate CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
ptaPhosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
pcaF3-oxoadipyl-CoA thiolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
aldA_1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
pykAPyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (489 aa)
bphJAcetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (302 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
lpdDihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
Your Current Organism:
Neisseria canis
NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6
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