STRINGSTRING
PET112 PET112 ERV15 ERV15 YCL046W YCL046W YCR095W-A YCR095W-A YDL129W YDL129W SRF1 SRF1 RRG1 RRG1 YDR114C YDR114C BUD26 BUD26 IRC4 IRC4 YFR016C YFR016C IRC5 IRC5 YGL015C YGL015C GTF1 GTF1 CCM1 CCM1 YIL092W YIL092W IRC24 IRC24 PET130 PET130 IRC9 IRC9 YJR039W YJR039W IRC19 IRC19 GEP5 GEP5 YLR232W YLR232W IRC20 IRC20 HER2 HER2 RRT16 RRT16 YNL205C YNL205C RRG9 RRG9 YOR055W YOR055W IRC14 IRC14 YOR200W YOR200W IRC13 IRC13 BIL1 BIL1 RRG7 RRG7 RRG8 RRG8 YPR117W YPR117W
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PET112Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; Belongs to the GatB/GatE family. GatB subfamily. (541 aa)
ERV15ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. (142 aa)
YCL046WPutative uncharacterized protein YCL046W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C. (107 aa)
YCR095W-APutative protein of unknown function. (52 aa)
YDL129WUncharacterized protein YDL129W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress. (291 aa)
SRF1Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients. (437 aa)
RRG1Protein of unknown function; required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the RRG1 family. (365 aa)
YDR114CUncharacterized protein YDR114C; Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium. (100 aa)
BUD26Putative uncharacterized protein BUD26; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay. (95 aa)
IRC4Uncharacterized protein IRC4; Protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus. (179 aa)
YFR016CUncharacterized protein YFR016C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFR016C is not an essential gene. (1233 aa)
IRC5Uncharacterized ATP-dependent helicase IRC5; Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus. (853 aa)
YGL015CUncharacterized protein YGL015C; Putative protein of unknown function; null mutants accumulate cargo in the Golgi. (130 aa)
GTF1Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria. (183 aa)
CCM1Mitochondrial group I intron splicing factor CCM1; Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport. (864 aa)
YIL092WUncharacterized protein YIL092W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus. (633 aa)
IRC24Benzil reductase ((S)-benzoin forming) IRC24; Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
PET130Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. (347 aa)
IRC9Putative uncharacterized protein IRC9; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci. (130 aa)
YJR039WUncharacterized protein YJR039W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. (1121 aa)
IRC19Increased recombination centers protein 19; Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci. (230 aa)
GEP5Genetic interactor of prohibitin 5, mitochondrial; Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; Belongs to the GEP5 family. (293 aa)
YLR232WPutative uncharacterized protein YLR232W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5. (115 aa)
IRC20Uncharacterized ATP-dependent helicase IRC20; E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci. (1556 aa)
HER2Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase. (464 aa)
RRT16Putative regulator of rDNA transcription protein 16; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription. (142 aa)
YNL205CPutative uncharacterized protein YNL205C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. (140 aa)
RRG9Required for respiratory growth protein 9, mitochondrial; Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. (214 aa)
YOR055WPutative uncharacterized protein YOR055W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. (144 aa)
IRC14Putative increased recombination centers protein 14; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci. (113 aa)
YOR200WPutative uncharacterized protein YOR200W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c. (132 aa)
IRC13Increased recombination centers protein 13; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci. (104 aa)
BIL1Uncharacterized protein YOR304C-A; Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck. (76 aa)
RRG7Required for respiratory growth protein 7, mitochondrial; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene. (242 aa)
RRG8Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; Belongs to the RRG8 family. (277 aa)
YPR117WUncharacterized protein YPR117W; Putative protein of unknown function. (2489 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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