STRINGSTRING
PRE7 PRE7 UMP1 UMP1 PRE1 PRE1 PUP3 PUP3 BLM10 BLM10 PRE4 PRE4 SCL1 SCL1 PRE8 PRE8 PRE5 PRE5 PRE6 PRE6 PUP1 PUP1 PRE2 PRE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRE7Beta 6 subunit of the 20S proteasome. (241 aa)
UMP1Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly. (148 aa)
PRE1Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; Belongs to the peptidase T1B family. (198 aa)
PUP3Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10. (205 aa)
BLM10Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200. (2143 aa)
PRE4Beta 7 subunit of the 20S proteasome; Belongs to the peptidase T1B family. (266 aa)
SCL1Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family. (252 aa)
PRE8Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family. (250 aa)
PRE5Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family. (234 aa)
PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family. (254 aa)
PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z. (261 aa)
PRE2Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; Belongs to the peptidase T1B family. (287 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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