| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAR1 | CAR2 | YPL111W | YLR438W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | 0.999 |
| CAR1 | PRO1 | YPL111W | YDR300C | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.673 |
| CAR1 | PRO2 | YPL111W | YOR323C | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.788 |
| CAR1 | PRO3 | YPL111W | YER023W | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.755 |
| CAR2 | CAR1 | YLR438W | YPL111W | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.999 |
| CAR2 | PRO1 | YLR438W | YDR300C | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.988 |
| CAR2 | PRO2 | YLR438W | YOR323C | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.964 |
| CAR2 | PRO3 | YLR438W | YER023W | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.963 |
| CAR2 | YHR033W | YLR438W | YHR033W | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Uncharacterized protein YHR033W; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication. | 0.961 |
| PRO1 | CAR1 | YDR300C | YPL111W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.673 |
| PRO1 | CAR2 | YDR300C | YLR438W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | 0.988 |
| PRO1 | PRO2 | YDR300C | YOR323C | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.999 |
| PRO1 | PRO3 | YDR300C | YER023W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.997 |
| PRO1 | YHR033W | YDR300C | YHR033W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Uncharacterized protein YHR033W; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication. | 0.901 |
| PRO2 | CAR1 | YOR323C | YPL111W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.788 |
| PRO2 | CAR2 | YOR323C | YLR438W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | 0.964 |
| PRO2 | PRO1 | YOR323C | YDR300C | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.999 |
| PRO2 | PRO3 | YOR323C | YER023W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.997 |
| PRO2 | YHR033W | YOR323C | YHR033W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Uncharacterized protein YHR033W; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication. | 0.999 |
| PRO3 | CAR1 | YER023W | YPL111W | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance. | 0.755 |