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VAR1 VAR1 MRPL16 MRPL16 MRP21 MRP21 MRPL36 MRPL36 MRPS9 MRPS9 MRPS5 MRPS5 MRPL37 MRPL37 MRPL27 MRPL27 MRPL32 MRPL32 IMG1 IMG1 IMG2 IMG2 MRP10 MRP10 MRPL11 MRPL11 EHD3 EHD3 RSM10 RSM10 MRX14 MRX14 RSM24 RSM24 MRPL7 MRPL7 MRPL35 MRPL35 MRPS28 MRPS28 MRP1 MRP1 MRP20 MRP20 MRPL28 MRPL28 RSM28 RSM28 RML2 RML2 RSM18 RSM18 MNP1 MNP1 RSM23 RSM23 MRPL25 MRPL25 MRP13 MRP13 MRPS35 MRPS35 RSM27 RSM27 MRPL9 MRPL9 MRP4 MRP4 FYV4 FYV4 MRPL6 MRPL6 RSM25 RSM25 MRPL8 MRPL8 MRPL49 MRPL49 RSM26 RSM26 RSM7 RSM7 MRP17 MRP17 RSM22 RSM22 MRP49 MRP49 MRPL38 MRPL38 QRI5 QRI5 MRPL4 MRPL4 MRPL39 MRPL39 YML6 YML6 MRPL3 MRPL3 MRPS8 MRPS8 MRPS17 MRPS17 MRPL24 MRPL24 MRPL33 MRPL33 MRP7 MRP7 SWS2 SWS2 NAM9 NAM9 MRPL22 MRPL22 MRPL17 MRPL17 MRPL10 MRPL10 MRPS18 MRPS18 MRPS12 MRPS12 RSM19 RSM19 MRPL23 MRPL23 PET123 PET123 MRPS16 MRPS16 MRP51 MRP51 MRPL40 MRPL40 RTC6 RTC6 MRPL51 MRPL51 MRP2 MRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAR1Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions. (398 aa)
MRPL16Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation. (232 aa)
MRP21Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences. (177 aa)
MRPL36Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region. (177 aa)
MRPS9Mitochondrial ribosomal protein of the small subunit. (278 aa)
MRPS5Mitochondrial ribosomal protein of the small subunit. (307 aa)
MRPL37Mitochondrial ribosomal protein of the large subunit. (105 aa)
MRPL27Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP. (146 aa)
MRPL32Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress. (183 aa)
IMG1Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome. (169 aa)
IMG2Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49. (146 aa)
MRP10Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria. (95 aa)
MRPL11Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2. (249 aa)
EHD33-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis. (500 aa)
RSM10Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins. (203 aa)
MRX14Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress. (105 aa)
RSM24Mitochondrial ribosomal protein of the small subunit. (319 aa)
MRPL7Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein. (292 aa)
MRPL35Mitochondrial ribosomal protein of the large subunit; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily. (367 aa)
MRPS28Mitochondrial ribosomal protein of the small subunit. (286 aa)
MRP1Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein. (321 aa)
MRP20Mitochondrial ribosomal protein of the large subunit. (263 aa)
MRPL28Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress. (147 aa)
RSM28Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation. (361 aa)
RML2Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor. (393 aa)
RSM18Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein. (138 aa)
MNP1Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth. (194 aa)
RSM23Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p. (450 aa)
MRPL25Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan. (157 aa)
MRP13Mitochondrial ribosomal protein of the small subunit. (339 aa)
MRPS35Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets. (345 aa)
RSM27Mitochondrial ribosomal protein of the small subunit. (110 aa)
MRPL9Mitochondrial ribosomal protein of the large subunit. (269 aa)
MRP4Mitochondrial ribosomal protein of the small subunit. (394 aa)
FYV4Protein FYV4, mitochondrial; Protein of unknown function; required for survival upon exposure to K1 killer toxin; Belongs to the mitochondrion-specific ribosomal protein mS41 family. (130 aa)
MRPL6Mitochondrial ribosomal protein of the large subunit. (214 aa)
RSM25Mitochondrial ribosomal protein of the small subunit. (264 aa)
MRPL8Mitochondrial ribosomal protein of the large subunit. (238 aa)
MRPL49Mitochondrial ribosomal protein of the large subunit. (161 aa)
RSM26Mitochondrial ribosomal protein of the small subunit. (266 aa)
RSM7Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein. (247 aa)
MRP17Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. (131 aa)
RSM22Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. (628 aa)
MRP49Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation. (137 aa)
MRPL38Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress. (138 aa)
QRI5Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA. (111 aa)
MRPL4Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit. (319 aa)
MRPL39Mitochondrial ribosomal protein of the large subunit. (70 aa)
YML6Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins. (286 aa)
MRPL3Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (390 aa)
MRPS8Mitochondrial ribosomal protein of the small subunit. (155 aa)
MRPS17Mitochondrial ribosomal protein of the small subunit. (237 aa)
MRPL24Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene. (258 aa)
MRPL33Mitochondrial ribosomal protein of the large subunit. (86 aa)
MRP7Mitochondrial ribosomal protein of the large subunit. (371 aa)
SWS2Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2. (143 aa)
NAM937S ribosomal protein NAM9, mitochondrial; Mitochondrial ribosomal component of the small subunit; Belongs to the universal ribosomal protein uS4 family. (486 aa)
MRPL22Mitochondrial ribosomal protein of the large subunit. (309 aa)
MRPL17Mitochondrial ribosomal protein of the large subunit. (281 aa)
MRPL10Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels. (322 aa)
MRPS18Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins. (217 aa)
MRPS1237S ribosomal protein S12, mitochondrial; Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins; Belongs to the universal ribosomal protein uS12 family. (153 aa)
RSM19Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein. (91 aa)
MRPL23Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2. (163 aa)
PET123Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator. (318 aa)
MRPS16Mitochondrial ribosomal protein of the small subunit. (121 aa)
MRP51Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences. (344 aa)
MRPL40Mitochondrial ribosomal protein of the large subunit. (297 aa)
RTC654S ribosomal protein RTC6, mitochondrial; Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress; Belongs to the bacterial ribosomal protein bL36 family. (93 aa)
MRPL51Mitochondrial ribosomal protein of the large subunit. (140 aa)
MRP2Mitochondrial ribosomal protein of the small subunit. (115 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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