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AVT5 AVT5 RTC2 RTC2 VBA2 VBA2 YCL002C YCL002C ATG22 ATG22 VBA3 VBA3 GEX1 GEX1 ERS1 ERS1 YCR090C YCR090C YDR090C YDR090C VBA4 VBA4 YPQ2 YPQ2 ERD1 ERD1 AVT6 AVT6 YJL163C YJL163C AVT1 AVT1 AVT3 AVT3 VBA1 VBA1 YMR155W YMR155W AVT4 AVT4 AMF1 AMF1 AGC1 AGC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AVT5Vacuolar amino acid transporter 5; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication; Belongs to the amino acid/polyamine transporter 2 family. (459 aa)
RTC2Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication; Belongs to the laat-1 family. (296 aa)
VBA2Permease of basic amino acids in the vacuolar membrane; Belongs to the major facilitator superfamily. (474 aa)
YCL002CPutative protein of unknown function; YCL002C is not an essential gene. (263 aa)
ATG22Autophagy-related protein 22; Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; Belongs to the ATG22 family. (528 aa)
VBA3Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication; Belongs to the major facilitator superfamily. (458 aa)
GEX1Glutathione exchanger 1; Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication. (615 aa)
ERS1Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS. (260 aa)
YCR090CUPF0587 protein YCR090C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene; Belongs to the UPF0587 family. (182 aa)
YDR090CUncharacterized membrane protein YDR090C; Putative protein of unknown function. (310 aa)
VBA4Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene; Belongs to the major facilitator superfamily. (768 aa)
YPQ2Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; Belongs to the laat-1 family. (317 aa)
ERD1Protein ERD1; Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p); Belongs to the ERD1 family. (362 aa)
AVT6Vacuolar amino acid transporter 6; Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication. (448 aa)
YJL163CUncharacterized membrane protein YJL163C; Putative protein of unknown function. (555 aa)
AVT1Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. (602 aa)
AVT3Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters. (692 aa)
VBA1Permease of basic amino acids in the vacuolar membrane; Belongs to the major facilitator superfamily. (562 aa)
YMR155WUncharacterized membrane protein YMR155W; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen. (547 aa)
AVT4Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs). (713 aa)
AMF1Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene; Belongs to the major facilitator superfamily. (515 aa)
AGC1Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family. (902 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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